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Patient-controlled analgesia with lornoxicam vs. dipyrone for acute postoperative pain relief after septorhinoplasty: a prospective, randomized, double-blind, placebo-controlled study

Published online by Cambridge University Press:  01 March 2008

M. Sener ,
C. Yilmazer ,
I. Yilmaz ,
E. Caliskan ,
A. Donmez  and
G. Arslan
M. Sener*
Affiliation:
Baskent University, Faculty of Medicine, Department of Anesthesiology, Ankara, Turkey
C. Yilmazer
Affiliation:
Baskent University, Faculty of Medicine, Department of Otolaryngology, Ankara, Turkey
I. Yilmaz
Affiliation:
Baskent University, Faculty of Medicine, Department of Otolaryngology, Ankara, Turkey
E. Caliskan
Affiliation:
Baskent University, Faculty of Medicine, Department of Anesthesiology, Ankara, Turkey
A. Donmez
Affiliation:
Baskent University, Faculty of Medicine, Department of Anesthesiology, Ankara, Turkey
G. Arslan
Affiliation:
Baskent University, Faculty of Medicine, Department of Anesthesiology, Ankara, Turkey
*
Correspondence to: Mesut Sener, Baskent Universitesi Adana Seyhan Hastanesi, Anesteziyoloji ve Reanimasyon AD, Baraj yolu 1. durak no: 37, TR01140 Seyhan/Adana, Turkey. E-mail: [email protected]; Tel: +90 322 4586868 Ext. 1226; Fax: +90 322 4592622
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Summary

Background and objective

We compared the efficacy of intravenous lornoxicam vs. dipyrone in patient-controlled analgesia for postoperative analgesia.

Methods

The study included 105 patients who had undergone elective septorhinoplasty after receiving general anaesthesia. Patients were divided into three groups to receive lornoxicam (24 mg day−1), dipyrone (5 g day−1) or placebo. Pain was evaluated using a 0–100 mm visual analogue scale at 2, 4, 6, 8, 12, 16, 20 and 24 h postoperatively. Pethidine (1 mg kg−1) was administered intramuscularly to patients requiring rescue analgesia. Pethidine requirements were recorded during the first 24 h postoperatively, and treatment-related adverse effects were noted.

Results

Postoperative pain scores were significantly lower with lornoxicam compared with dipyrone at 8 h (P = 0.016). No significant differences regarding pain scores at 2, 4, 6, 12, 16, 20 and 24 h were found. Significantly fewer patients in the lornoxicam group required rescue analgesics (vs. dipyrone, P = 0.046; vs. placebo, P = 0.001); fewer patients in the dipyrone group required rescue analgesics compared with placebo (P = 0.008). Significantly fewer patients in the lornoxicam group had nausea (vs. dipyrone, P = 0.022; vs. placebo, P = 0.006); no significant differences were found between the other two groups. Antiemetic use was significantly lower in the lornoxicam group (vs. dipyrone, P = 0.002; vs. placebo, P = 0.001).

Conclusions

Lornoxicam has better tolerability and is a more effective analgesic than dipyrone when administered by patient-controlled analgesia for postoperative analgesia after septorhinoplasty.

Keywords

PAIN POSTOPERATIVELORNOXICAMDIPYRONEANALGESIAPATIENT CONTROLLEDRANDOMIZED CONTROLLED TRIAL
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 25 , Issue 3 , March 2008 , pp. 177 - 182
Copyright
Copyright © European Society of Anaesthesiology 2008

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