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The effects of sevoflurane and desflurane on lipid peroxidation during laparoscopic cholecystectomy

Published online by Cambridge University Press:  23 December 2004

G. M. Koksal ,
C. Sayilgan ,
S. Aydin ,
H. Uzun  and
H. Oz
G. M. Koksal
Affiliation:
Istanbul University Cerrahpasa Medical Faculty, Departments of Anaesthesiology and Reanimation, Istanbul, Turkey
C. Sayilgan
Affiliation:
Istanbul University Cerrahpasa Medical Faculty, Departments of Anaesthesiology and Reanimation, Istanbul, Turkey
S. Aydin
Affiliation:
Istanbul University Cerrahpasa Medical Faculty, Department of Biochemistry, Istanbul, Turkey
H. Uzun
Affiliation:
Istanbul University Cerrahpasa Medical Faculty, Department of Biochemistry, Istanbul, Turkey
H. Oz
Affiliation:
Istanbul University Cerrahpasa Medical Faculty, Departments of Anaesthesiology and Reanimation, Istanbul, Turkey
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Abstract

Summary

Background and objective: To compare the effects of sevoflurane and desflurane anaesthesia on lipid peroxidation.

Methods: We studied 40 healthy patients undergoing elective laparoscopic cholecystectomy. Patients were randomly allocated to be anaesthetized either with sevoflurane (n = 20) or desflurane (n = 20). Anaesthesia was maintained with inspiratory concentrations of sevoflurane 1–1.5 MAC (n = 20) or desflurane (n = 20). Samples were taken for plasma malondialdehyde and superoxide dismutase assays before induction of anaesthesia, before skin incision and at the end of surgery. Alveolar cell samples were obtained from the lungs using the technique of protective blind bronchoalveolar lavage, after induction of anaesthesia and at the end of surgery for malondialdehyde and superoxide dismutase concentrations.

Results: Plasma malondialdehyde increased more after the administration of desflurane than after sevoflurane: after induction 5.9 ± 0.6 nmol mL−1 for desflurane vs. 3.8 ± 0.5 nmol L−1 for sevoflurane (P < 0.001); at the end of the surgery: 6.7 ± 0.4 nmol mL−1 for desflurane vs. 4.2 ± 0.3 nmol mL−1 for sevoflurane (P < 0.001). There was a small but significant increase in plasma superoxide dismutase concentration after desflurane – from 24.2 ± 1.2 to 24.9 ± 0.9U mL−1 after induction and 25 ± 1U mL−1 at the end of the surgery (P < 0.01) but no increase with sevoflurane. Malondialdehyde concentrations increased significantly in the cells obtained by protective blind bronchoalveolar lavage at the end of surgery in the desflurane group (from 0.3 ± 0.1 to 1.7 ± 0.2 nmol mL−1 (P < 0.001)), but not in the sevoflurane group. There were no significant differences between the two anaesthetics in the amounts of superoxide dismutase in the samples obtained by protective blind bronchoalveolar lavage.

Conclusions: Desflurane may cause more systemic and regional lipid peroxidation than sevoflurane during laparoscopic cholecystectomy in healthy human beings.

Keywords

ALDEHYDES, malondialdehyde, thiobarbituric acid reactive substancesANAESTHETICS INHALATION, desflurane, sevofluraneENERGY METABOLISM, oxidation–reduction, lipid peroxidationENZYMES, oxidoreductases, superoxide dismutaseINVESTIGATIVE TECHNIQUES, irrigation, bronchoalveolar lavage
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 21 , Issue 3 , March 2004 , pp. 217 - 220
Copyright
2004 European Society of Anaesthesiology

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