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Effects of hydroxyethyl starch on blood coagulation profile

Published online by Cambridge University Press:  16 August 2006

H. Türkan ,
A. U. Ural ,
C. Beyan  and
A. Yalçin
H. Türkan
Affiliation:
Department of Anaesthesiology, Gölcük Naval Hospital, 41650 Gölcük/Izmit, Turkey
A. U. Ural
Affiliation:
Department of Hematology, Gülhane Military Medical Academy, Etlik/Ankara, Turkey
C. Beyan
Affiliation:
Department of Hematology, Gülhane Military Medical Academy, Etlik/Ankara, Turkey
A. Yalçin
Affiliation:
Department of Hematology, Gülhane Military Medical Academy, Etlik/Ankara, Turkey
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Abstract

The effects of hydroxyethyl starch on blood coagulation were investigated in 20 patients undergoing surgery to determine whether its use places recipients at risk of haemorrhage or thrombosis. The partial thromboplastin times are significantly prolonged; factor VIII activities and fibrinogen levels are decreased. After infusion of hydroxyethyl starch, no significant differences were detected in platelet count or prothrombin time. A decreased platelet aggregation was also found after the infusion of hydroxyethyl starch. According to our results, hydroxyethyl starch can cause haemorrhagic problems in patients when administered as a colloidal volume-expanding agent.

Keywords

hydroxyethyl starchcoagulation
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 16 , Issue 3 , March 1999 , pp. 156 - 159
Copyright
1999 European Society of Anaesthesiology

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