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Effects of different doses of oral ketamine for premedication of children

Published online by Cambridge University Press:  02 June 2005

S. Turhanoğlu ,
A. Kararmaz ,
M. A. Özyilmaz ,
S. Kaya  and
D. Tok
S. Turhanoğlu
Affiliation:
Dicle University Hospital, Department of Anaesthesiology, Diyarbakir, Turkey
A. Kararmaz
Affiliation:
Dicle University Hospital, Department of Anaesthesiology, Diyarbakir, Turkey
M. A. Özyilmaz
Affiliation:
Dicle University Hospital, Department of Anaesthesiology, Diyarbakir, Turkey
S. Kaya
Affiliation:
Dicle University Hospital, Department of Anaesthesiology, Diyarbakir, Turkey
D. Tok
Affiliation:
Dicle University Hospital, Department of Anaesthesiology, Diyarbakir, Turkey
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Extract

Summary

Background and objective: A need exists for a safe and effective oral preanaesthetic medication for use in children undergoing elective surgery. The study sought to define the dose of oral ketamine that would facilitate induction of anaesthesia without causing significant side-effects.

Methods: We studied 80 children undergoing elective surgery under general anaesthesia who received oral ketamine 4, 6 or 8 mg kg−1 in a prospective, randomized, double-blind placebo controlled study. We compared the reaction to separation from parents, transport to the operating room, the response to intravenous cannula insertion and application of an anaesthetic facemask, the induction of anaesthesia and recovery from anaesthesia.

Results: In the group receiving ketamine 8 mg kg−1, the children were significantly calmer than those of the other groups, and anaesthesia induction was more comfortable. Recovery from anaesthesia was longer in the group receiving ketamine 8 mg kg−1 compared with the other groups, but no differences between the groups were observed after 2 h in the recovery room.

Conclusions: It is concluded that oral ketamine 8 mg kg−1 is an effective oral premedication in inpatient children undergoing elective surgery.

Keywords

ANAESTHETICS, INTRAVENOUS, anaesthetics, dissociative, ketaminePAEDIATRICSPREMEDICATION
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 20 , Issue 1 , January 2003 , pp. 56 - 60
Copyright
© 2003 European Society of Anaesthesiology

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