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Effects of dexmedetomidine on the duration of anaesthesia and wakefulness in bupivacaine epidural block

Published online by Cambridge University Press:  01 June 2007

I. Coskuner ,
M. Tekin ,
I. Kati ,
C. Yagmur  and
K. Elcicek
I. Coskuner
Affiliation:
Yuzuncu Yil University, Medical Faculty, Anesthesiology and Reanimation Department, Van, Turkey
M. Tekin
Affiliation:
Yuzuncu Yil University, Medical Faculty, Anesthesiology and Reanimation Department, Van, Turkey
I. Kati*
Affiliation:
Yuzuncu Yil University, Medical Faculty, Anesthesiology and Reanimation Department, Van, Turkey
C. Yagmur
Affiliation:
Yuzuncu Yil University, Medical Faculty, Anesthesiology and Reanimation Department, Van, Turkey
K. Elcicek
Affiliation:
Yuzuncu Yil University, Medical Faculty, Anesthesiology and Reanimation Department, Van, Turkey
*
Correspondence to: Ismail Kati, Anesthesiology and Reanimation Department, Medical Faculty, Yuzuncu Yil University, Van, Turkey. E-mail: [email protected]; Tel: +90 432 2122651; Fax: +90 432 2122651
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Summary

Background

The purpose of this study was to examine the effects of intravenous dexmedetomidine on the duration of bupivacaine-induced epidural anaesthesia and level of wakefulness and the respective side-effects.

Methods

Sixty ASA I–II patients were included in the study. Consecutive patients were allocated to groups according to the last digit (odd/even) of their admission numbers. All patients had epidural anaesthesia with bupivacaine 0.5% performed by the same experienced anaesthesiologist. In the first group, the patients were administered intravenous dexmedetomidine infusion just after the epidural block and continued during the operation, while those in the second group were administered physiologic saline infusion at the same amount and duration.

Results

The recovery time of sensory block was significantly longer in the first group. The bispectral index values were lower in the first group than in the second. Also, heart rate was significantly lower in Group I than in Group II. Regarding side-effects, shivering was significantly less frequent in the first group, whereas there was a significant increase in the requirement of atropine in the first group as dexmedetomidine caused bradycardia.

Conclusion

Intravenous administration of dexmedetomidine prolonged the duration of epidural anaesthesia, provided sedation and had few side-effects.

Keywords

BUPIVACAINEANAESTHESIA EPIDURALbispectral indexDEXMEDETOMIDINESEDATION
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 24 , Issue 6 , June 2007 , pp. 535 - 540
Copyright
Copyright © European Society of Anaesthesiology 2007

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