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The effect of propofol on the neutrophil respiratory burst

Published online by Cambridge University Press:  04 August 2006

P. G. Murphy ,
A. J. Ogilvy  and
S. M. Whiteley
P. G. Murphy
Affiliation:
Department of Anaesthesia, The General Infirmary at Leeds, Great George Street, Leeds, UK
A. J. Ogilvy
Affiliation:
University Department of Anaesthesia, Leicester Royal Infirmary, Leicester, UK
S. M. Whiteley
Affiliation:
Department of Anaesthesia, The General Infirmary at Leeds, Great George Street, Leeds, UK
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Abstract

We have examined the effect of propofol on the neutrophil respiratory burst. Chemiluminescence was used as a measure of the respiratory burst following stimulation with 10−5m N-formyl-L-methionyl-L-leucyl-L-phenylalanine.Propofol 1.25, 2.5 and 5.0 × 10−5m inhibited neutrophil chemiluminescence by 29.6, 43.0 and 57.6%, respectively, in neutrophils prepared from healthy adult volunteers, and by 25.5, 37.4 and 54.7% in cells from patients with severe sepsis. We conclude that propofol interferes with the ability of human neutrophils to generate reactive oxygen species.

Keywords

anaestheticsintravenouspropofolneutrophilsrespiratory burst
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 13 , Issue 5 , May 1996 , pp. 471 - 473
Copyright
1996 European Society of Anaesthesiology

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