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Double-blind randomized study of tramadol vs. paracetamol in analgesia after day-case tonsillectomy in children

Published online by Cambridge University Press:  16 August 2006

P. E. Pendeville
Affiliation:
Department of Anaesthesiology, Catholic University of Louvain Medical School – Saint-Luc Hospital, Avenue Hippocrate 10/1821, 1200 Brussels, Belgium
S. Von Montigny
Affiliation:
Department of Anaesthesiology, Catholic University of Louvain Medical School – Saint-Luc Hospital, Avenue Hippocrate 10/1821, 1200 Brussels, Belgium
J. P. Dort
Affiliation:
Department of Anaesthesiology, Catholic University of Louvain Medical School – Saint-Luc Hospital, Avenue Hippocrate 10/1821, 1200 Brussels, Belgium
F. Veyckemans
Affiliation:
Department of Anaesthesiology, Catholic University of Louvain Medical School – Saint-Luc Hospital, Avenue Hippocrate 10/1821, 1200 Brussels, Belgium
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Abstract

Fifty children (2–9 years) scheduled for tonsillectomy were enrolled in a double-blind randomized prospective study to compare postoperative analgesia provided with propacetamol/paracetamol (acetaminophen) or tramadol. A standard anaesthetic technique was used; each patient received sufentanil 0.25 μg kg−1 intravenously followed with either i.v. propacetamol 30 mg kg−1 or tramadol 3 mg kg−1 before surgical incision. For postoperative analgesia, each child received either tramadol drops (2.5 mg kg−1) or paracetamol (acetaminophen) suppositories (15 mg kg−1), 6 and 12 h after surgery the first day and three times a day during postoperative days 2 and 3. This dosage of paracetamol is lower than the current recommended dosage, which is 40 mg kg−1 loading dose followed by 20 mg kg−1 8 h−1. Rescue medication consisted of i.v. diclofenac (1 mg kg−1) during the first six postoperative hours and oral ibuprofen (6–9 mg kg−1) afterwards. Postoperative pain scores (Children's Hospital of Eastern Ontario Pain Scale) in recovery, numerical pain scale in the ward and at home, and rescue analgesic use were significantly lower in the tramadol group. No serious adverse effects were observed.

Type
Original Article
Copyright
2000 European Society of Anaesthesiology

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