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Dose-response and concentration-response relation of rocuronium infusion during propofol-nitrous oxide and isoflurane-nitrous oxide anaesthesia

Published online by Cambridge University Press:  16 August 2006

M. Kansanaho
Affiliation:
Department of Anaesthesia, University of Helsinki, Helsinki, Finland
K. T. Olkkola
Affiliation:
Department of Anaesthesia, University of Helsinki, Helsinki, Finland
J. M. K. H. Wierda
Affiliation:
Research Group for Experimental Anaesthesiology and Clinical Pharmacology, University Hospital, Groningen, The Netherlands
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Abstract

The dose-response and concentration-response relation of rocuronium infusion was studied in 20 adult surgical patients during propofol-nitrous oxide and isoflurane (1 MAC) -nitrous oxide anaesthesia. Neuromuscular block was kept constant, initially at 90% and then at 50% with a closed-loop feedback controller. At 90% block the steady-state infusion of rocuronium was 0.55 ± 0.16 mg kg−1 h−1 and the corresponding concentration 1714 ± 281 ng mL−1 in patients receiving propofol. At 50% block the corresponding infusion rate was 0.27 ± 0.11 mg kg−1 h−1 and the concentration 1077 ± 244 ng mL−1, respectively. At 50% block isoflurane reduced the rate of infusion by 52% (P < 0.005) and the concentration by 59% (P < 0.001); at 90% block both the mean infusion rate and the concentration of rocuronium were reduced by 35% (P <0.005). The mean rocuronium clearance at 50% block was unaffected by the type of anaesthesia; it was 4.1 ± 1.6 and 4.9 ± 2.7 mL kg−1 min−1 in the groups receiving propofol and isoflurane anaesthesia, respectively. We conclude that isoflurane reduces the infusion requirements of rocuronium by changing the pharmacodynamic behaviour.

Type
Original Article
Copyright
1997 European Society of Anaesthesiology

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