Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-05T05:02:04.493Z Has data issue: false hasContentIssue false

Disposition of propofol between red blood cells, plasma, brain and cerebrospinal fluid in rabbits

Published online by Cambridge University Press:  16 August 2006

P. L. De Riu
Affiliation:
Department of Traumatology, Orthopedy and Occupational Medicine, Turin University, Italy
G. De Riu
Affiliation:
Department of Maxillofacial Surgery, Parma University, Italy
C. Testa
Affiliation:
Zooprophylactic Institute, Sassari, Italy
M. Mulas
Affiliation:
Institute of Anaesthesia, Italy
M. A. Caria
Affiliation:
Department of Biomedical Sciences, Human Physiol. Divison Italy
S. Mameli
Affiliation:
Chair of Cardiology, Sassari University, Italy
O. Mameli
Affiliation:
Department of Biomedical Sciences, Human Physiol. Divison Italy
Get access

Abstract

The disposition of propofol in the blood and brain of New Zealand rabbits was studied in three groups of six rabbits. One group received a single anaesthetic dose; a second group received a 1-h infusion; and a third group was studied after the rabbits were judged to have recovered from a 1-h infusion. There was a high concentration of propofol in the red blood cell fraction and in the brain, however, the red blood cell concentration largely exceeded the one found in the brain in all groups of animals. This is consistent with the high fat solubility of diisopropylphenol. The possible effects of propofol sequestered in red blood cells is discussed.

Type
Original Article
Copyright
2000 European Society of Anaesthesiology

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)