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Comparison of intravenous metoprolol, verapamil and diltiazem on the attenuation of haemodynamic changes associated with tracheal extubation

Published online by Cambridge University Press:  16 August 2006

D. Yörükoǧlu ,
A. Göktug ,
Z. Alanoǧlu  and
M. Tulunay
D. Yörükoǧlu
Affiliation:
Department of Anaesthesiology and Intensive Care, Medical School of Ankara University, Ankara, Turkey
A. Göktug
Affiliation:
Department of Anaesthesiology and Intensive Care, Medical School of Ankara University, Ankara, Turkey
Z. Alanoǧlu
Affiliation:
Department of Anaesthesiology and Intensive Care, Medical School of Ankara University, Ankara, Turkey
M. Tulunay
Affiliation:
Department of Anaesthesiology and Intensive Care, Medical School of Ankara University, Ankara, Turkey
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Abstract

Changes in heart rate, systolic, diastolic and mean blood pressure were measured after extubation in 60 ASA Grade I and II patients to assess the effects of diltiazem (0.2 mg kg−1), verapamil (0.05 mg kg−1) and metoprolol (0.02 mg kg−1) given as a bolus 2 min before tracheal extubation. All the haemodynamic variables measured increased significantly after extubation in the control and diltiazem groups when compared with the base-line recordings (P<0.05). Metoprolol effectively blocked the increases in heart rate after extubation and the increase in blood pressure in this group was less when compared with the control group (P<0.05). Verapamil alleviated the increase in both heart rate and blood pressure. However, profound hypotension and bradycardia requiring therapy, occurred in the verapamil group. For this reason, careful observation is necessary when using variverapamil and the routine use of this drug in patients with coronary artery disease requires further studies.

Keywords

extubationcardiovascular responsesdiltiazemverapamilmetoprolol
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 16 , Issue 7 , July 1999 , pp. 462 - 467
Copyright
1999 European Society of Anaesthesiology

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