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Comparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam

Published online by Cambridge University Press:  07 July 2006

G. T. Keleş ,
S. Kurutepe ,
D. Tok ,
H. Gazi  and
G. Dinç
G. T. Keleş
Affiliation:
University of Celal Bayar, Department of Anaesthesiology and Intensive Care, Manisa, Turkey
S. Kurutepe
Affiliation:
University of Celal Bayar, Department of Microbiology and Clinical Microbiology, Manisa, Turkey
D. Tok
Affiliation:
University of Celal Bayar, Department of Anaesthesiology and Intensive Care, Manisa, Turkey
H. Gazi
Affiliation:
University of Celal Bayar, Department of Microbiology and Clinical Microbiology, Manisa, Turkey
G. Dinç
Affiliation:
University of Celal Bayar, Department of Public Health, Manisa, Turkey
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Abstract

Summary

Background and objectives: The aim of our study was to investigate the antimicrobial effects of dexmedetomidine and etomidate-lipuro, and to compare these effects with those of midazolam and propofol on Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, Acinetobacter baumannii and extended-spectrum beta-lactamase Escherichia coli ( E. coli ESBL). Methods: All hypnotic dilutions were exposed to micro-organisms for 0, 30, 60, 120 and 240 min at room temperature in vitro. The inoculums taken from diluted suspensions were re-inoculated on blood agar and incubated for 18–24 h at 35°C after which a count of the colonies was compared. Results: Midazolam reduced the viable cells of S. aureus at 30, 60, 120 and 240 min, and also completely inhibited the growth of E. coli, P. aeroginosa, A. baumannii and E. coli ESBL. Dexmedetomidine, etomidate-lipuro and propofol, however, did not inhibit any of the micro-organisms tested. Conclusion:In vitro, midazolam had an antimicrobial effect on E. coli, P. aeroginosa, A. baumannii and E. coli ESBL. Like propofol and dexmedetomidine, etomidate-lipuro had no antimicrobial effect on any of the micro-organisms tested.

Keywords

ANAESTHETICS INTRAVENOUS, etomidate, midazolam, propofolADRENERGIC ALPHA AGONISTS, dexmedetomidineAGENTS ANTIMICROBIALANTIMICROBIAL ACTIVITY
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 12 , December 2006 , pp. 1037 - 1040
Copyright
2006 European Society of Anaesthesiology

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