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Clonidine inhibits gastric motility in the rat

Published online by Cambridge University Press:  16 August 2006

T. Asai ,
M. D. Vickers  and
I. Power
T. Asai
Affiliation:
Department of Anaesthetics and Intensive Care Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
M. D. Vickers
Affiliation:
Department of Anaesthetics and Intensive Care Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
I. Power
Affiliation:
Department of Anaesthesia and Pain Management, Royal North Shore Hospital and University of Sydney, St. Leonards, NSW 2065, Australia
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Abstract

We have studied the effect of clonidine on gastric motility, by examining the effect on gastric emptying of indigestible solids. In Wistar rats, either clonidine or saline was injected intraperitoneally, and ten steel balls (1.0mm in diameter) were inserted into the stomach. Gastric emptying was examined at 3 h. Clonidine delayed gastric emptying of steel balls (ED50 = 0.0071 [95% confidence interval: 0.0033–0.013) mg kg−1). Yohimbine, but not naloxone, significantly antagonized the inhibitory effect of clonidine. We conclude that clonidine inhibits gastric motility through the alpha2 adrenoceptor.

Keywords

gastrointestinal tractmotilitymeasurementtechniquessteel ball testcomplicationsgastric stasis
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 14 , Issue 3 , May 1997 , pp. 316 - 319
Copyright
1997 European Society of Anaesthesiology

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