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Aprotinin; friend or foe? A review of recent medical literature

Published online by Cambridge University Press:  14 November 2006

D. Royston ,
N. van Haaften  and
P. De Vooght
D. Royston
Affiliation:
Royal Brompton and Harefield NHS Trust, Harefield Hospital, Department of Cardiothoracic Anaesthesiaand Critical Care, Harefield, UK
N. van Haaften
Affiliation:
Royal Brompton and Harefield NHS Trust, Harefield Hospital, Department of Cardiothoracic Anaesthesiaand Critical Care, Harefield, UK
P. De Vooght
Affiliation:
Royal Brompton and Harefield NHS Trust, Harefield Hospital, Department of Cardiothoracic Anaesthesiaand Critical Care, Harefield, UK
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Extract

Summary

Recent articles published in peer review journals have questioned the safety of using aprotinin in patients having heart surgery. Also, evidence has been published to suggest an increase in renal events in patients given aprotinin when compared to those where tranexamic acid was used. The present review will focus principally on the first of these articles in relation to previously published data and experience.

Keywords

APROTININCARDIAC SURGICAL PROCEDURESREVIEW, LITERATURETRANEXAMIC ACIDADVERSE EFFECTSBLOOD TRANSFUSION
Type
Review
Information
European Journal of Anaesthesiology , Volume 24 , Issue 1 , January 2007 , pp. 6 - 14
Copyright
© 2006 European Society of Anaesthesiology

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