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Unchanged rat brain amyloid precursor protein levels after exposure to benzodiazepines in vivo

Published online by Cambridge University Press:  12 June 2006

J. Kálmán ,
M. Palotás ,
M. Pákáski ,
M. Hugyecz ,
Z. Janka  and
A. Palotás
J. Kálmán
Affiliation:
University of Szeged, Department of Psychiatry, Szeged, Hungary
M. Palotás
Affiliation:
University of Szeged, Department of Psychiatry, Szeged, Hungary University of Szeged, Department of Anesthesiology and Intensive Therapy, Szeged, Hungary
M. Pákáski
Affiliation:
University of Szeged, Department of Psychiatry, Szeged, Hungary
M. Hugyecz
Affiliation:
University of Szeged, Department of Psychiatry, Szeged, Hungary
Z. Janka
Affiliation:
University of Szeged, Department of Psychiatry, Szeged, Hungary
A. Palotás
Affiliation:
University of Szeged, Department of Psychiatry, Szeged, Hungary University of Szeged, Department of Center for Cardiology, Division of Cardiac Surgery, Albert Szent-Györgyi Medical and Pharmaceutical Center, Szeged, Hungary
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Abstract

Summary

Background and objective: Recent studies emphasize a positive correlation between (cardiac) surgical interventions and increased risk for developing Alzheimer's disease in the late postoperative period. Since amyloid precursor protein and its neurotoxic derivatives play key roles in the development of Alzheimer's dementia, the impact of several agents used in the intra- and perioperative period is examined. Method: Amyloid precursor protein concentrations were assessed by semi-quantitative Western-immunoblot in brains of rats following intraperitoneal treatment with diazepam and midazolam. Results: There were no significant changes in the amyloid precursor protein concentrations. Conclusion: Both diazepam and midazolam are considered to be relatively safe with respect to amyloid precursor protein metabolism.

Keywords

ANAESTHESIA GENERALBENZODIAZEPINES, diazepam, midazolamALZHEIMER DISEASEAMYLOID BETA-PROTEIN PRECURSORPOSTOPERATIVE PERIOD, cognitive dysfunction
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 9 , September 2006 , pp. 772 - 775
Copyright
2006 European Society of Anaesthesiology

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