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Rocuronium duration of action under sevoflurane, desflurane or propofol anaesthesia

Published online by Cambridge University Press:  28 January 2005

P. G. Maidatsi ,
A. Th. Zaralidou ,
N. K. Gorgias ,
E. N. Amaniti ,
K. A. Karakoulas  and
M. M. Giala
P. G. Maidatsi
Affiliation:
AHEPA University Hospital, Anaesthesiology Department, Thessaloniki, Greece
A. Th. Zaralidou
Affiliation:
AHEPA University Hospital, Anaesthesiology Department, Thessaloniki, Greece
N. K. Gorgias
Affiliation:
‘Saint Demetrios’ General Hospital, Anaesthesiology Department, Thessaloniki, Greece
E. N. Amaniti
Affiliation:
AHEPA University Hospital, Anaesthesiology Department, Thessaloniki, Greece
K. A. Karakoulas
Affiliation:
AHEPA University Hospital, Anaesthesiology Department, Thessaloniki, Greece
M. M. Giala
Affiliation:
AHEPA University Hospital, Anaesthesiology Department, Thessaloniki, Greece
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Extract

Summary

Background and objective: We conducted a prospective randomized study to evaluate whether the duration of action of a single bolus dose of rocuronium is influenced by maintenance of anaesthesia with sevoflurane, desflurane or propofol infusion.

Methods: Fifty-seven ASA I–II patients undergoing elective abdominal surgery were enrolled in this study. Anaesthesia was induced with thiopental 3–5 mg kg−1 or propofol 2.5 mg kg−1 and fentanyl 5 μg kg−1 and tracheal intubation was facilitated with rocuronium 0.9 mg kg−1. Thereafter patients were randomly allocated to three different groups to receive sevoflurane, desflurane or propofol for maintenance of anaesthesia. Recovery of neuromuscular function was monitored by single twitch stimulation of the ulnar nerve and by recording the adductor pollicis response using accelerometry. Intergroup recovery times to 5% of control value of single twitch were analysed using analysis of variance with Bonferroni correction.

Results: The mean (95% confidence interval) recovery time to 5% of control value of single twitch during desflurane anaesthesia was 90.18 (86.11–94.25) min. Significantly shorter recovery times were observed during sevoflurane or propofol anaesthesia, 58.86 (54.73–62.99) min and 51.11 (45.47–56.74) min, respectively (P < 0.001). There were also significant differences in the recovery time between groups receiving desflurane vs. sevoflurane (P < 0.001) and desflurane vs. propofol (P < 0.001).

Conclusions: Desflurane anaesthesia significantly prolongs the duration of action of rocuronium at 0.9 mg kg−1 single bolus dose, compared to sevoflurane or propofol anaesthesia maintenance regimens.

Keywords

ANAESTHETICS INHALATION, sevoflurane, desfluraneANAESTHETICS INTRAVENOUS, propofolNEUROMUSCULAR BLOCKING AGENTS, rocuronium, monitoring, duration of action
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 21 , Issue 10 , October 2004 , pp. 781 - 786
Copyright
© 2004 European Society of Anaesthesiology

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