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Pulse dye densitometry using indigo carmine is useful for cardiac output measurement, but not for circulating blood volume measurement

Published online by Cambridge University Press:  23 December 2004

Y. Fujita ,
T. Yamamoto ,
M. Fuse ,
N. Kobayashi ,
S. Takeda  and
T. Aoyagi
Y. Fujita
Affiliation:
Kawasaki Medical School, Department of Anesthesiology and ICM, Okayama, Tokyo, Japan
T. Yamamoto
Affiliation:
Kawasaki Medical School, Department of Urology, Okayama, Tokyo, Japan
M. Fuse
Affiliation:
Research and Development Laboratory, Nihon Kohden Co., Tokyo, Japan
N. Kobayashi
Affiliation:
Research and Development Laboratory, Nihon Kohden Co., Tokyo, Japan
S. Takeda
Affiliation:
Research and Development Laboratory, Nihon Kohden Co., Tokyo, Japan
T. Aoyagi
Affiliation:
Research and Development Laboratory, Nihon Kohden Co., Tokyo, Japan
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Abstract

Summary

Background and objective: We evaluated the validity of a newly developed pulse dye densitometer for indigo carmine for measuring cardiac output and circulating blood volume.

Methods: Measurements of cardiac output and circulating blood volume were performed with the indigo carmine densitometer during normovolaemia, hypovolaemia and hypervolaemia in nine mongrel dogs under general anaesthesia. The validity was evaluated by comparison of the values of cardiac output and circulating blood volume obtained by the thermodilution technique and the 51Cr-labelled red blood cell method, respectively. We also examined indigo carmine removal by continuous veno-venous haemofiltration after indigo carmine injection.

Results: There was good agreement between dye densitometer- and thermodilution-derived cardiac output (r = 0.885, P < 0.001). The bias and limits of agreement of these values were 0.09 and ± 1.07L min−1 (2 SD, n = 22), respectively. The dye-densitometer-derived circulating blood volume was greater than that of the 51Cr-labelled red blood cell method, and both values showed weak agreement (r = 0.587, P < 0.027). The sieving coefficient of indigo carmine through continuous veno-venous haemofiltration was 0.34 ± 0.06.

Conclusions: These data indicate that indigo carmine densitometry is a reliable method for cardiac output determination, but it overestimates circulating blood volume, probably due to the transition of indigo carmine into the extravascular space in the systemic circulation.

Keywords

CARDIAC OUTPUTDIAGNOSTIC TECHNIQUES, cardiovascular, blood volume determinationINVESTIGATIVE TECHNIQUESindicator-dilution technique, dye-dilution technique, indigo carmine
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 21 , Issue 8 , August 2004 , pp. 632 - 637
Copyright
2004 European Society of Anaesthesiology

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