Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-23T12:45:41.194Z Has data issue: false hasContentIssue false
  • English
  • Français

Propofol inhibits potassium chloride induced contractions of isolated human umbilical vessels

Published online by Cambridge University Press:  27 January 2006

E. Caliskan ,
Z. Kayhan  and
H. Tufan
E. Caliskan
Affiliation:
Baskent University, Faculty of Medicine, Adana Teaching and Medical Research Center, Department of Anaesthesiology, Adana, Turkey
Z. Kayhan
Affiliation:
Baskent University, Faculty of Medicine, Department of Anaesthesiology, Ankara, Turkey
H. Tufan
Affiliation:
Baskent University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey
Get access

Abstract

Summary

Background and objective: We have evaluated the effects of propofol and its relationship with K+ channels on human isolated umbilical vessels. Methods: Umbilical vessel rings were suspended in isolated organ baths containing Krebs–Ringer solution. In the first series of experiments the effect of propofol (10−9–10−4M) was examined in a concentration-dependent manner on umbilical vessels precontracted with KCl (60 mmol). In the second series, these effects were studied in the presence of tetraethylammonium. Results: A mild contraction was produced by low dose propofol in both precontracted umbilical artery and umbilical vein segments. 10−4M propofol caused significant relaxation in both umbilical artery and umbilical vein. The relaxation response was significantly reduced by the addition of 10−1 M tetraethylammonium. Conclusion: These results suggested that the responses of propofol on KCl-induced contractions of both umbilical artery and vein were dose dependent, and this effect involved Ca2+ activated K+ channels.

Keywords

INTRAVENOUS ANAESTHETIC AGENTS, propofolUMBILICAL ARTERIESUMBILICAL VEINSPOTASSIUM CHANNELSVASOCONSTRICTION
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 5 , May 2006 , pp. 411 - 417
Copyright
2006 European Society of Anaesthesiology

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Dailland P, Cockshott I, Lirzin DJet al. Intravenous propofol during Caesarean section: placental transfer, concentrations in breast milk and neonatal effects. A preliminary study. Anesthesiology 1989; 71: 827–834.Google Scholar
Imura N, Shiraishi Y, Katsuya H, Itoh T. Effect of propofol on norepinephrine-induced increases in [Ca++]i and force in smooth muscle of the rabbit mesenteric resistance artery. Anesthesiology 1998; 88: 1566–1578.Google Scholar
Morgan EG, Mikhail SM. Maternal and fetal physiology and anesthesia. In: Appleton and Lange: Clinical Anesthesiology, 3rd edn.New York, USA: McGraw-Hill Companies, 2002: 804–818.
Gin T. Pharmacokinetic optimisation of general anaesthesia in pregnancy. Clin Pharmacokin Ther 1993; 25: 59–70.Google Scholar
Fields AS, Eric M. Obstetric analgesia and anaesthesia. A Review. Primary Care 1993; 20: 705–712.Google Scholar
Nakamura K, Hatano Y, Hirakata H, Nishiwada M. Direct vasoconstrictor and vasodilator effects of propofol in isolated dog arteries. Br J Anaesth 1992; 68: 193–197.Google Scholar
Robinson BJ, Ebert JT, Colinco MD. Mechanisms whereby propofol mediates peripheral vasodilatation in humans. Anesthesiology 1997; 86: 64–72.Google Scholar
Park KW, Lynch C, Roger AJ. Effects of propofol and thiopental in isolated rat aorta and pulmonary artery. Anesthesiology 1992; 77: 956–963.Google Scholar
Yamanoue T, Brum MJ, Estafanous FG. Vasodilatation and mechanism of action of propofol in porcine coronary artery. Anesthesiology 1994; 81: 443–451.Google Scholar
Wallerstedt MS, Törnebrandt K, Bodelson M. Relaxant effects of propofol on human omental arteries and veins. Br J Anaesth 1998; 80: 655–659.Google Scholar
Bently GN, Gent JP, Goodchild CS. Vascular effects of propofol: smooth muscle relaxation in isolated veins and arteries. J Pharmacia Pharmacol 1995; 23: 34–42.Google Scholar
Introna RPS, Pruett JK, Yodlowski EH. Direct effects of propofol on canine coronary artery ring tension. Gen Pharmacol 1993; 24: 497–502.Google Scholar
Moreno L, MartinezCuesta MA, Muedra V, Beltran B, Esplugues J. Role of the endothelium in the relaxation induced by propofol and thiopental in isolated arteries from man. J Pharm Pharmacol 1997; 49: 430–432.Google Scholar
Tanabe K, Kozawa O, Kaida Tet al. Inhibitory effects of propofol on intracellular signaling by endothelin-1 in aortic smooth muscle cells. Anesthesiology 1998; 88: 452–460.Google Scholar
He Y-L, Seno H, Tsujimoto S, Tashiro C. The effects of uterine and umbilical blood flows on the transfer of propofol across the human placenta during in vitro perfusion. Anesth Analg 2001; 93: 151–156.Google Scholar
Valtonen M, Kanto J, Rosenberg P. Comparison of propofol and thiopentone for induction of anaesthesia for elective Caesarean section. Anaesthesia 1989; 44: 758–762.Google Scholar
Errasti EA, Werneck de Avellar CM, Daray MF. Human umbilical vein vasoconstriction induced by epinephrine acting on α1B-adrenoceptor subtype. Am J Obstet Gynecol 2003; 189: 1472–1480.Google Scholar
Gacar N, Gok S, Kalyoncu N. The effect of endothelium on the response to propofol on bovine coronary artery. Acta Anaesth Scand 1995; 39: 1080–1083.Google Scholar
Wallerstedt MS, Törnebrandt K, Bodelson M. Relaxant effects of propofol on human omental arteries and veins. Br J Anaesth 1998; 80: 655–659.Google Scholar
Goodchild CS, Serrao JLM. Cardiovascular effects of propofol in the anaesthetized dog. Br J Anaesth 1989; 63: 87–92.Google Scholar
Kirkpatrick T, Cockshott D, Douglas EJ, Nimmo WS. Pharmacokinetics of propofol (diprivan) in elderly patients. Br J Anaesth 1988; 60: 146–150.Google Scholar
Alcaraz SA, Quintana MB, Laguarda M. Placental transfer and neonatal effects of propofol in Caesarean section. J Clin Pharm Ther 1998; 23: 19–23.Google Scholar
He Y-L, Tsujimoto S, Tanimoto M, Okutani R, Murakawa K, Tashiro C. Effects of protein binding on the placental transfer of propofol in the human dually perfused cotyledon in vitro. Br J Anaesth 2000; 85: 281–286.Google Scholar