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Post-craniotomy analgesia: current practices in British neurosurgical centres – a survey of post-craniotomy analgesic practices

Published online by Cambridge University Press:  11 May 2005

G. C. Roberts
Affiliation:
University Hospital of Wales, B4 Neurosurgery, Cardiff, Wales, UK
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Extract

Summary

Background and objective: An evaluation of post-craniotomy analgesia within the University Hospital of Wales Neurosurgical Unit, Cardiff, found that many patients were experiencing moderate to severe pain post-craniotomy. It was therefore decided to undertake a nationwide survey of analgesic practices in order to establish best practice guidelines and benchmark with other units.

Method: A postal questionnaire was sent to the senior nurse of every Neurosurgical Directorate within the UK inquiring about the current, standard analgesic practices for post-craniotomy patients in their unit.

Results: Completed replies were received from 23 of the 33 centres (70%). Intramuscular (i.m.) codeine phosphate was found to be the principal first-line analgesic used post-craniotomy. Only three centres used morphine as the first-line analgesic and only one centre used patient controlled analgesia routinely. The majority of centres (82%) used balanced analgesia. Pain assessments were only carried out in 57% of centres and no centre used a validated pain assessment tool specifically for dysphasic patients.

Conclusions: Codeine phosphate continues to be the mainstay of post-craniotomy analgesia, however, it is proposed that patient controlled analgesia with morphine is an efficacious and safe alternative.

Type
Original Article
Copyright
© 2005 European Society of Anaesthesiology

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References

Aitkenhead A, Smith G, eds. Neurosurgical Anaesthesia, 3rd edn. New York, USA: Churchill Livingstone Inc, 1998.
Craft T, Upton P. Key Topics in Anaesthetia, 2nd edn. Oxford, England: BIOS Scientific Publishers Ltd, 1997.
Drummond J, Patel P. Neurosurgical Anaesthesia. In: Miller R, ed. Anaesthesia, 5th edn, Vol. 2. New York, USA: Churchill Livingstone Inc, 2000.
Atkinson R, Rushman G, Davies N. Lees Synopsis of Anaesthesia, 11th edn. Oxford, England: Butterworth Heinnemann Ltd, 1993.
Feldman S. Neurological conditions and anaesthesia. In: Churchill Davidson H, ed. A Practice of Anaesthesia, 5th edn. London, England: Lloyd Luke (Medical Books) Ltd, 1984.
Turner J. Anaesthesia for neurosurgery. In: Healey T, Cohen P, eds. A Practice of Anaesthesia, 6th edn. London, England: Edward Arnold, 1995.
Geevarghese K. Post operative care of the patient undergoing neurological surgery. Int Anaesthesiol Clin 1977; 15: 309320.Google Scholar
Stoneham M, Cooper R, Quiney N, Walters F. Pain following a craniotomy: a preliminary study comparing PCA morphine with intramuscular codeine phosphate. Anaesthesia 1996; 51: 11761178.Google Scholar
Stoneham M, Walters F. Post operative analgesia for craniotomy patients: current attitudes among neuroanaesthetists. Eur J Anaesthesiol 1995; 12: 571575.Google Scholar
Goldsack C, Souplak S, Smith M. A double blind comparison of codeine and morphine for post operative analgesia following intracranial surgery. Anaesthesia 1996; 51: 10291032.Google Scholar
Graham A, Reid M, Andrews P. Perception of pain experienced and adequacy of analgesia following elective craniotomy. Anaesthesia 1999; 54: 814815.Google Scholar
De Benedittis G, Lorenzetti A, Miglione M, et al. Post-operative pain in neurosurgery: a pilot study in brain surgery. Neurosurgery 1996 38: 466470.Google Scholar
Directory of Critical Care. Directory of Critical Care UK. London, England: CMA Medical Data, 2003.
Cousins M, Umedaly H. Post-operative pain management in the neurosurgical patient. Int Anaesthesiol Clin 1996; 34: 179193.Google Scholar
Way W, Fields H, Schumacher M. Opioid analgesics and antagonists. In: Katzung B, ed. Basic and Clinical Pharmacology, 8th edn. New York, USA: Langer Medical Books, 2001.
Dollery C. Therapeutic Drugs, Vol. 1. Edinburgh, Scotland: Churchill Livingstone Inc, 1991.
Chen ZR, Somogyi AA, Reynolds G, Bochner F. Disposition and metabolism of codeine after single and chronic doses in one poor and seven extensive metabolisers. Br J Clin Pharmacol 1991; 31: 381390.Google Scholar
Desmules J, Gascon M, Dayer P, et al. Impact of environmental and genetic factors on codeine analgesia. Eur J Clin Pharmacol 1991; 41: 2326.Google Scholar
Yue Q, Hasselstrom J, Svensson J, et al. Pharmokinetics of codeine and its metabolites in Caucasian healthy volunteers. Br J Clin Pharmacol 1991; 31: 635642.Google Scholar
Quilding H, Lundqvist G, Boreus L, et al. Analgesic effect and concentration of codeine and morphine after 2 dose levels of codeine following oral surgery. Eur J Clin Pharmacol 1993; 44: 319323.Google Scholar
Sindrup S, Brosen K, Bjerring P, et al. Codeine increases pain thresholds to copper vapour laser treatment stimuli in EMs but not PMs of sparteine. Clin Pharmacol 1993; 49: 686694.Google Scholar
Williams D, Patel A, Howard R. Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability. Br J Anaesth 2002; 89: 839884.Google Scholar
Chen Z, Somogyi A, Bochner F. Polymorphic demethylation of codeine. Lancet 1988; 2: 914915.Google Scholar
Eckhardt K, Shuxia L, Ammon S, et al. Same incidence of adverse events after codeine administration irrespective of the genetically determined differences in morphine formation. Pain 1998; 76: 2733.Google Scholar
Poulsen L, Brasen K, Arendt-Nielsen L, et al. Codeine and morphine in extensive and poor metabolizers of sparteine. Eur J Clin Pharmacol 1996; 51: 289295.Google Scholar
Leith B. Pharmacological management of pain after intracranial surgery. J Neurosci Nurs 1998; 30: 220224.Google Scholar
Rivet M. The use of IV codeine in the neurosurgical patient population. J Can Assoc Crit Care Nurs 1995; 6: 1215.Google Scholar
Austin K, Stapleton J, Mather L. Multiple IM injections. Pain 1980; 8: 4762.Google Scholar
Semel J. Fever associated with repeated IM injections of analgesics. Rev Infect Disease 1986; 8: 6872.Google Scholar
Quiney N, Cooper R, Stoneham M, et al. Pain after craniotomy – a time for reappraisal? Br J Neurosurg 1996; 10: 295299.Google Scholar
Ng K, Tsui J, Yang S, et al. Increased nausea and dizziness when using tramadol for postoperative PCA compared with morphine. Eur J Anaesthesiol 1998: 15: 565570.Google Scholar
Pang W, Mok M, Lin C, et al. Comparison of PCA with tramadol or morphine Can J Anaesth 1999; 46: 10301035.Google Scholar
Jeffrey H, Charlton P, Mellor D, et al. Analgesia after intracranial surgery: a double blind prospective comparison of codeine and tramadol. Br J Anaesth 1999; 83: 245249.Google Scholar
Stubhaug A, Grimstad J, Breivik H. Lack of analgesic effect of 50 and 100 mg oral tramadol after orthopaedic surgery. Pain 1995; 62: 111118.Google Scholar
Stamer U, Maier C, Grondt B, et al. Tramadol in the management of post operative pain: a double blind, placebo and active drug controlled study. Eur J Anaesthesiol 1997; 14: 646654.Google Scholar
Herbert C. Use of morphine for pain after intracranial surgery. Professional Nurse 2001; 16: 10291033.Google Scholar
Kathirvel S, Dash H, Bhatia A, et al. Effect of prophylactic ondansetron on post-operative nausea and vomiting after elective craniotomy. J Neurosurg Anaesth 2001; 13: 207212.Google Scholar
Gardner J, Blough D, Drinkard C, et al. Tramadol and seizures. Pharmacotherapy 2001; 20: 14231431.Google Scholar
Jick H. The risks of seizure associated with tramadol. Pharmacotherapy 1998; 18: 607611.Google Scholar
Cold GE, Felding M. Even small doses of morphine might provoke ‘luxury perfusion’ in the postoperative period after craniotomy. Neurosurgery 1993; 32: 327.Google Scholar
Vickers M, Szekely S, Read M, et al. Tramadol: pain relief by an opioid without fear of depression of respiration. Anaesthesia 1992; 47: 291296.Google Scholar
Pasero C, McCaffery M. Avoiding opioid-induced respiratory depression. Am J Nurs 1994; 94: 2530.Google Scholar
Carroll D. Pain assessment. In: Carroll D, Bowsher D, eds. Pain Management and Nursing Care. Oxford, UK: Butterworth Heinneman Ltd, 1993.
Voepel-Lewis T, Merkel S, Tait AR, et al. The reliability and validity of the face, legs, activity, cry, consolability observational tool as a measure of pain in children with cognitive impairment. Anesth Analg 2002; 95: 12241229.Google Scholar
Terstegen C, Koot HM, de Boer JB, et al. Measuring pain in cognitive impairment: pain response to surgical procedures. Pain 2003; 103: 187198.Google Scholar