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Pharmacological study of BRS, a new bicarbonated Ringer's solution, in partially hepatectomized rabbits

Published online by Cambridge University Press:  28 July 2005

K. Satoh ,
M. Ohtawa ,
E. Okamura ,
T. Satoh  and
A. Matsuura
K. Satoh
Affiliation:
Pharmacology Laboratory, Shimizu Research Center, Shimizu Pharmaceutical Co., Ltd., Shizuoka, Japan
M. Ohtawa
Affiliation:
Pharmacology Laboratory, Shimizu Research Center, Shimizu Pharmaceutical Co., Ltd., Shizuoka, Japan
E. Okamura
Affiliation:
Pharmacology Laboratory, Shimizu Research Center, Shimizu Pharmaceutical Co., Ltd., Shizuoka, Japan
T. Satoh
Affiliation:
Tokyo Clinical Development Center Tokyo, Japan
A. Matsuura
Affiliation:
Pharmacology Laboratory, Shimizu Research Center, Shimizu Pharmaceutical Co., Ltd., Shizuoka, Japan
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Summary

Background and objective: The effects of bicarbonated Ringer's solution were evaluated and compared with those of acetated Ringer's, lactated Ringer's and Ringer's solutions in partially hepatectomized rabbits. Method: Animals were randomly divided into six groups (n = 6 in each group): a sham-operated group, an operated group without infusion, and four operated groups with infusions of each of the four Ringer's solutions. Each Ringer's solution was intravenously administered at 40 mL kg−1 h−1 for 1.5 h. Arterial blood gases, plasma magnesium concentrations and cardiovascular parameters were analysed. Results: The partial hepatectomy-induced decrement of base excess was inhibited by bicarbonated Ringer's solution more remarkably than by either lactated or plain solutions (P < 0.01). The alkalinizing effect of bicarbonated Ringer's solution tended to be more marked than that of the acetated solution but not significantly so. Plasma magnesium concentrations were well maintained by bicarbonated solution as compared to the other solutions (P < 0.01). Conclusions: These results suggest that bicarbonated Ringer's solution is the most suitable perioperative solution for metabolic acidosis and plasma electrolyte balance among the Ringer's solutions tested.

Keywords

RINGER'S SOLUTION, bicarbonate, acetate, lactateACIDOSIS, metabolicRABBITHEPATECTOMY, partial
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 22 , Issue 8 , August 2005 , pp. 624 - 629
Copyright
© 2005 European Society of Anaesthesiology

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