Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-26T16:03:32.405Z Has data issue: false hasContentIssue false
  • English
  • Français

No difference in electroencephalographic power spectra or sensory-evoked potentials in patients anaesthetized with desflurane or sevoflurane

Published online by Cambridge University Press:  23 December 2004

E. Freye ,
J. Brückner  and
L. Latasch
E. Freye
Affiliation:
Heinrich-Heine-University Clinics of Düsseldorf, Clinics of Vascular Surgery and Renal Transplantation, Düsseldorf, Germany
J. Brückner
Affiliation:
Charité University Hospital, Department of Anaesthesia and Intensive Care Therapy, Berlin (CVK), Germany
L. Latasch
Affiliation:
Nordwest Hospital, Department of Anaesthesia and Pain Therapy, Frankfurt, Germany
Get access

Abstract

Summary

Background and objective: Hitherto, neither desflurane nor sevoflurane, with similar physicochemical properties, have been compared with regard to their effects on the central nervous system. We compared the effects of desflurane and sevoflurane on electrical cortical activity and sensory transmission at two anaesthetic concentrations in patients undergoing hysterectomy.

Methods: The 1 and 2 MAC in nitrous oxide/oxygen (55%/45%) of desflurane or sevoflurane were administered while electroencephalographic power spectra and the somatosensory-evoked potentials were measured and correlated with cardiovascular effects.

Results: Both volatile agents induced a concentration-related increase of power in the slow delta-band and a concomitant decrease of power in the fast beta-domain. There was a close correlation with regard to the decrease in beta-power and heart rate (r2 = 0.988) and systolic blood pressure (r2 = 0.952) following both agents. Desflurane and sevoflurane had little effect on the early N20-peak, but affected the late N100-peak. There was a concentration-related increase in latency and a depression of amplitude height. Changes were not significantly different between both agents.

Conclusions: Both desflurane and sevoflurane possess a similar profile with regard to their hypnotic effects and a similar outline in depressing propagation within the sensory nervous system. Cortical nervous effects are mirrored closely in heart rate and systolic blood pressure.

Keywords

ANAESTHETICS, INHALATION, desflurane, sevofluraneELECTROENCEPHALOGRAPHYEVOKED POTENTIALS, somatosensory
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 21 , Issue 5 , May 2004 , pp. 373 - 378
Copyright
2004 European Society of Anaesthesiology

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Whitten CW, Elmore JC, Latson TW. Desflurane: a review. Progr Anesthesiol 1993; 7: 46–58.Google Scholar
Nathanson MH, Fredman B, Smith I, White PF. Sevoflurane versus desflurane for outpatient anesthesia: a comparison of maintenance and recovery profiles. Anesth Analg 1995; 81: 1186–1190.Google Scholar
Ornstein E, Young WL, Fleischer LH, Ostapkovich MC. Desflurane and isoflurane have similar effects on cerebral blood flow in patients with intracranial mass lesions. Anesthesiology 1993; 79: 498–502.Google Scholar
Weiskopf RB, Eger 2nd EI, Noorani M, Daniel M. Repetitive rapid increases in desflurane concentration blunt transient cardiovascular stimulations in humans. Anesthesiology 1994; 81: 843–849.Google Scholar
Moore MA, Weiskopf RB, Eger 2nd EI, Noorane M, McKay L, Damask M. Rapid 1% increases of end-tidal desflurane concentration to greater than 5% transiently increases heart rate and blood pressure in humans. Anesthesiology 1994; 81: 94–98.Google Scholar
Adachi M, Ikemoto Y, Kubo K, Takuma C. Seizure-like activity during induction of anaesthesia with sevoflurane. Br J Anaesth 1992; 68: 214–215.Google Scholar
Komatsu H, Taie S, Endo S, et al. Electrical seizures during sevoflurane anesthesia in two pediatric patients with epilepsy. Anesthesiology 1994; 81: 1535–1537.Google Scholar
Chapman CR, Chen ACN, Harkins SW. Brain evoked potentials as correlates of laboratory pain: a review and perspective. In: Bonica JJ, Liebeskind JC, Albe-Fessard DG, eds. Advances in Pain Research and Therapy, Vol. 3.New York, USA: Raven Press, 1979: 791–803.
Chapman CR, Colpitts YM, Benedetti C, Butler S. Event-related potential correlates of analgesia; comparison of fentanyl, acupuncture and nitrous oxide. Pain 1982; 14: 327–337.Google Scholar
Eger 2nd EI, Saidmann LJ, Brandstater B. Minimum alveolar anesthetic concentration: a standard of anesthetic potency. Anesthesiology 1965; 26: 559–576.Google Scholar
Rampil I, Mason P, Singh H. Anesthetic potency (MAC) is independent of forebrain structures in the rat. Anesthesiology 1993; 78: 707–712.Google Scholar
Eger 2nd EI. Desflurane animal and human pharmacology: aspects of kinetics, safety, and MAC. Anesth Analg 1992; 75 (Suppl. 4): 3–9.Google Scholar
Yasuda N, Targ AG, Eger 2nd EI. Solubility of I-653, sevoflurane, isoflurane, and halothane in human tissues. Anesth Analg 1989; 69: 370–373.Google Scholar
Rampil IJ, Lockhart SH, Eger 2nd EI, Yasuda N, Weiskopf RB, Cahalan MK. The electroencephalographic effects of desflurane in humans. Anesthesiology 1991; 74: 434–439.Google Scholar
Tatsumi K, Hirai K, Furuya H, Okuda T. Effects of sevoflurane on the middle latency auditory evoked response and the electroencephalographic power spectrum. Dose related increase in delta and decrease in beta. Anesth Analg 1995; 80: 940–943.Google Scholar
Eger 2nd EI, Stevens WC, Cromwell TH. The electroencephalogram in man anesthetized with forane. Anesthesiology 1971; 35: 504–508.Google Scholar
Davis HS, Collins WF, Randt CT, Dillon WH. Effects of anesthetic agents on evoked central nervous systems responses: gaseous agents. Anesthesiology 1957; 18: 634–642.Google Scholar
Drummond JC, Brann CA, Perkins DE, Wolfe DE. A comparison of median frequency, spectral edge frequency, band power ratio, total power, and dominance shift in the determination of depth of anaesthesia. Acta Anaesth Sand 1991; 35: 693–699.Google Scholar
Vaughan DJA, Thornton C, Wright JR, et al. Effects of different concentrations of sevoflurane and desflurane on subcortical somatosensory evoked responses in anaesthetized, non-stimulated patients. Br J Anaesth 2001; 86: 59.Google Scholar
Schindler E, Thiel A, Müller M, Milosevic M, Langer C, Hempelmann G. Veränderungen somatosensorisch evozierter Potentiale nach Sevofluran und Isofluran. Anaesthesist 1996; 45: S52–S56.Google Scholar
Sebel PS, Flynn PJ, Ingram DA. Effect of nitrous oxide on visual, auditory and somatosensory evoked potentials. Br J Anaesth 1984; 56: 1403–1407.Google Scholar
Sloan TB, Koht A. Depression of cortical somatosensory evoked potentials by nitrous oxide. Br J Anaesth 1985; 57: 849–852.Google Scholar
Sebel PS, Ingram DA, Flynn PJ, Rutherfoord CF, Rogers H. Evoked potentials during isoflurane anaesthesia. Br J Anaesth 1986; 58: 580–585.Google Scholar
Samra SK, Vanderzant CW, Tornow MA, Sackellares JC. Effect of isoflurane anesthesia on somatosensory evoked potentials. Electroenceph Clin Neurophysiol 1985; 61: 19P.Google Scholar
Sebel PS, Erwin CW, Neville WK. Effects of halothane and enflurane on far and near field somatosensory evoked potentials. Br J Anaesth 1987; 59: 1492–1496.Google Scholar
Foltz EL, White LE. Pain ‘relief’ by frontal cingulotomy. J Neurosurg 1962; 19: 89–100.Google Scholar
Freeman W, Watts JW. Pain mechanisms and the frontal lobes: a study of prefrontal lobotomy for intractable pain. Ann Intern Med 1948; 28: 747–754.Google Scholar
Friedman DP, Murray EA. Thalamic connectivity of the second somatosensory area and neighboring somatosensory fields of the lateral sulcus of the Macaque. J Comp Neurol 1986; 252: 348–373.Google Scholar
Kenshalo DR Jr, Isensee O. Responses of primates SI cortical neurons to noxious stimuli. J Neurophysiol 1983; 58: 1479–1496.Google Scholar
Guilbaud G, Benoist JM, Levante A, Gautron M, Willer JC. Primary somatosensory cortex in rats with pain-related behaviors due to peripheral mononeuropathy after moderate ligation of one sciatic nerve: neuronal responsivity to somatic stimulation. Exp Brain Res 1992; 92: 227–245.Google Scholar
Kochs E, Scharein E, Möllenberg O, Bromm B, Schulte am Esch J. Analgesic efficacy of low-dose ketamine: somatosensory evoked responses in relation to subjective pain ratings. Anesthesiology 1996; 85: 304–314.Google Scholar
Freye E, Hartung E, Schenk GK. Somatosensory-evoked potentials during block of surgical stimulation with propofol. Br J Anaesth 1989; 63: 357–359.Google Scholar
Kochs E, Treede RD, Schulte am Esch J, Bromm B. Modulation of pain-related somatosensory evoked potentials by general anesthesia. Anesth Analg 1990; 71: 225–230.Google Scholar