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Lornoxicam attenuates the haemodynamic responses to laryngoscopy and tracheal intubation in the elderly*

Published online by Cambridge University Press:  01 September 2008

W. Riad  and
A. Moussa
W. Riad*
Affiliation:
King Khaled Eye Specialist Hospital, Department of Anesthesia, Riyadh, Saudi Arabia
A. Moussa
Affiliation:
King Faisal Specialist Hospital and Research Center, Department of Anesthesia, Riyadh, Saudi Arabia
*
Correspondence to: Waleed Riad, Department of Anaesthesia, King Khaled Eye Specialist Hospital, PO Box 7191, Riyadh 11462, Saudi Arabia. E-mail: [email protected]; Tel: +966 1 482 1234 3215; Fax: +966 1 482 1908
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Summary

Background and objectives

Lornoxicam is a novel non-steroidal anti-inflammatory drug with marked analgesic property. It has been shown to have analgesic potency similar to morphine and meperidine. Laryngoscopy and tracheal intubation provoke major haemodynamic responses. Minimizing perioperative adverse events in elderly patients is of utmost importance. The aim of this study was to demonstrate the effect of preoperative administration of Lornoxicam on haemodynamic changes during laryngoscopy and tracheal intubation in the elderly.

Methods

Fifty patients aged between 65 and 75 yr were randomly recruited to this randomized, double-blind, placebo-controlled study. They were divided into two groups to receive either Lornoxicam 8 mg or placebo half an hour before surgery. Systolic and diastolic blood pressure, mean arterial pressure, and heart rate were recorded before and after administration of the intravenous anaesthetic, also at 1, 3, 5 and 10 min after tracheal intubation.

Results

In the control group, significant increases in the haemodynamic parameters were observed during the first 10 min following tracheal intubation (P < 0.05).

Conclusion

Preoperative administration of Lornoxicam attenuates the haemodynamic response to laryngoscopy and tracheal intubation in the elderly.

Keywords

ELDERLYANAESTHESIA, stress responseINTUBATION INTRATRACHEALLORNOXICAM
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 25 , Issue 9 , September 2008 , pp. 732 - 736
Copyright
Copyright © European Society of Anaesthesiology 2008

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Footnotes

*

Abstract presented in Euroanaesthesia meeting, Munich, June 2007.

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