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Evaluation of the anticoagulant properties of aprotinin in vitro

Published online by Cambridge University Press:  04 August 2006

E. Mortier ,
M. Ongenae ,
J. Van Aken ,
N. Den Blauwen  and
G. Rolly
E. Mortier
Affiliation:
Department of Anaesthesiology, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium
M. Ongenae
Affiliation:
Department of Anaesthesiology, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium
J. Van Aken
Affiliation:
Department of Anaesthesiology, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium
N. Den Blauwen
Affiliation:
Department of Anaesthesiology, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium
G. Rolly
Affiliation:
Department of Anaesthesiology, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium
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Abstract

The interaction of aprotinin with normal coagulation was studied in blood samples obtained from 10 healthy subjects. Each sample was simultaneously tested in four different preparations : NaCl-treated blood: 0.03 mL 0.9% NaCl in 0.33 mL blood; aprotinin treated blood : 0.33 mL blood+aprotinin in 0.03 mL in aliquots to obtain a final blood concentration of respectively 50 KIU mL−1; 100 KIU mL−1 and 200 KIU mL−1. The coagulation process was analysed by thromboelastography. R-time, reflecting intrinsic coagulation, increased in a dose dependent manner between NaCl-treated and aprotinin-treated blood. These findings suggest a dose dependent impairment of intrinsic coagulation by aprotinin.

Keywords

coagulationaprotininmeasurement techniquesthromboelastography
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 13 , Issue 5 , May 1996 , pp. 468 - 470
Copyright
1996 European Society of Anaesthesiology

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