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The effects of magnesium sulphate on sevoflurane minimum alveolar concentrations and haemodynamic responses

Published online by Cambridge University Press:  23 December 2005

M. Durmus ,
A. K. But ,
T. B. Erdem ,
Z. Ozpolat  and
M. O. Ersoy
M. Durmus
Affiliation:
Inonu University, School of Medicine, Department of Anaesthesiology, Malatya, Turkey
A. K. But
Affiliation:
Inonu University, School of Medicine, Department of Anaesthesiology, Malatya, Turkey
T. B. Erdem
Affiliation:
Inonu University, School of Medicine, Department of Anaesthesiology, Malatya, Turkey
Z. Ozpolat
Affiliation:
Inonu University, School of Medicine, Department of Anaesthesiology, Malatya, Turkey
M. O. Ersoy
Affiliation:
Inonu University, School of Medicine, Department of Anaesthesiology, Malatya, Turkey
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Summary

Background and objective: Magnesium administered before anaesthesia induction results in a significant reduction in intravenous anaesthetic consumption. The purpose of this study was to evaluate whether the dose of intravenous magnesium sulphate reduces the minimum alveolar anaesthetic concentration of sevoflurane for endotracheal intubation (MACEI) and skin incision (MAC), and attenuates haemodynamic responses. Methods: We studied 60 patients who were scheduled for elective surgery. Patients were not premedicated before induction of anaesthesia and were randomly assigned to receive intravenous saline 0.9% (Group I, n = 20) or magnesium sulphate 30 mg kg−1 bolus + 10 mg kg−1 h−1 continuous infusion (Group II, n = 20) or 50 mg kg−1 bolus + 10 mg kg−1 h−1 continuous infusion (Group III, n = 20). Results: Median and 95% confidence limits for sevoflurane MACEI were 2.68 (2.48–2.85), 2.88 (2.70–3.06) and 2.96 (2.70–3.16), and for sevoflurane MAC were 2.08 (1.76–2.40), 2.26 (2.08–2.47) and 2.40 (2.19–2.68) in Groups I, II and III, respectively. The differences in MACEI and MAC among groups were not statistically significant, except Group III in MAC study (P < 0.05). Mean arterial pressures and heart rate did not increase in Groups II and III after endotracheal intubation and skin incision. Conclusions: Magnesium sulphate administered before induction of anaesthesia increases MAC of sevoflurane and reduces cardiovascular responses to intubation.

Keywords

MAGNESIUMPHYSIOLOGICAL MEASUREMENT TECHNIQUES, blood pressure, heart rateANAESTHETICS INHALATIONAL, sevoflurane, minimum alveolar concentration
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 23 , Issue 1 , January 2006 , pp. 54 - 59
Copyright
© 2006 European Society of Anaesthesiology

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