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The addition of clonidine to prilocaine for intravenous regional anaesthesia

Published online by Cambridge University Press:  16 August 2006

S. Kleinschmidt ,
W. Stöckl ,
W. Wilhelm  and
R. Larsen
S. Kleinschmidt
Affiliation:
Department of Anaesthesiology and Critical Care Medicine, University of Saarland, D-66421 Homburg/Saar, Germany
W. Stöckl
Affiliation:
Department of Anaesthesiology and Critical Care Medicine, University of Saarland, D-66421 Homburg/Saar, Germany
W. Wilhelm
Affiliation:
Department of Anaesthesiology and Critical Care Medicine, University of Saarland, D-66421 Homburg/Saar, Germany
R. Larsen
Affiliation:
Department of Anaesthesiology and Critical Care Medicine, University of Saarland, D-66421 Homburg/Saar, Germany
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Abstract

The effect of the addition of clonidine 2 μg kg−1 to prilocaine 0.57% for intravenous regional anaesthesia (IVRA) in the arm was investigated in 56 healthy patients using a randomized, double-blind study. The characteristics of the sensory and motor block, quality of analgesia, development of post-operative pain sensations and haemodynamic variables were studied in three groups (IVRA with prilocaine, IVRA with prilocaine and clonidine, IVRA with prilocaine and systemic application of clonidine at tourniquet release). There were no significant differences between the groups concerning the onset and recovery characteristics of sensory and motor blockade, post-operative pain or side effects. In those patients receiving clonidine, mean arterial pressure decreased significantly (24–28%, respectively) after tourniquet release, while heart rate remained unchanged. Clonidine as an adjunct to prilocaine seems to be of limited benefit during and after intravenous regional anaesthesia.

Keywords

regional anaesthesiaintravenousclonidineprilocaine
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 14 , Issue 1 , January 1997 , pp. 40 - 46
Copyright
1997 European Society of Anaesthesiology

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