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Estimation of the hazard function in a semiparametric model with covariate measurement error

Published online by Cambridge University Press:  26 March 2009

Marie-Laure Martin-Magniette
Affiliation:
UMR AgroParisTech/INRA MIA 518, Paris, France. URGV UMR INRA 1165/CNRS 8114/UEVE, Évry, France.
Marie-Luce Taupin
Affiliation:
Université Paris Descartes, Laboratoire MAP5, Paris; [email protected]
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Abstract

We consider a failure hazard function,conditional on a time-independent covariate Z,given by $\eta_{\gamma^0}(t)f_{\beta^0}(Z)$ . The baseline hazardfunction $\eta_{\gamma^0}$ and the relative risk $f_{\beta^0}$ both belong to parametricfamilies with $\theta^0=(\beta^0,\gamma^0)^\top\in \mathbb{R}^{m+p}$ . The covariate Z has an unknown density and is measured with an error through anadditive error model U = Z + ε where ε is a random variable, independent from Z, withknown density $f_\varepsilon$ .We observe a n-sample (Xi, Di, Ui), i = 1, ..., n, where X i isthe minimum between the failure time and the censoring time,and D i is the censoring indicator.Using least square criterion and deconvolution methods, we propose a consistent estimator of θ 0 using the observationsn-sample (Xi, Di, Ui), i = 1, ..., n.
We give an upper bound for its riskwhich depends on the smoothness properties of $f_\varepsilon$ and $f_\beta(z)$ as afunction of z, and we derive sufficient conditionsfor the $\sqrt{n}$ -consistency.We give detailed examples consideringvarious type of relative risks $f_{\beta}$ and various types of errordensity $f_\varepsilon$ . In particular, in the Cox model and inthe excess risk model, the estimator of θ 0 is $\sqrt{n}$ -consistent and asymptotically Gaussianregardless of the form of $f_\varepsilon$ .

Type
Research Article
Copyright
© EDP Sciences, SMAI, 2009

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