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The influence of adrenaline on echocardiographic parameters of left ventricular function in the horse

Published online by Cambridge University Press:  09 March 2007

Heidrun Gehlen ,
Silke Marnette  and
Peter Stadler
Heidrun Gehlen*
Affiliation:
Clinic for Horses, School of Veterinary Medicine Hannover, Bischofsholer Damm 115, D-30173 Hannover, Germany
Silke Marnette
Affiliation:
Clinic for Horses, School of Veterinary Medicine Hannover, Bischofsholer Damm 115, D-30173 Hannover, Germany
Peter Stadler
Affiliation:
Clinic for Horses, School of Veterinary Medicine Hannover, Bischofsholer Damm 115, D-30173 Hannover, Germany
*
*[email protected]
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Abstract

The purpose of the present study was to investigate the effect of adrenaline on cardiac function parameters. The infusion of adrenaline for induction of stress, its prospective side-effects as well as its effect on left ventricular function were investigated. A clinical examination and echocardiography were performed on 10 healthy horses before and after infusion of adrenaline. During a period of 6 min, infusion of 1 μg adrenaline kg−1 min−1 led to a significant increase in mean heart rate, from 36.5 to 55 beats min−1. Echocardiography during adrenaline infusion revealed a significant thickening of the interventricular septum (during systole) as well as a significant decrease in left ventricular diameter at the papillary muscle level (during both systole and diastole), and thus an increased contractility. The left ventricular area and the left ventricular volume were significantly decreased during adrenaline infusion, expressing the increased left ventricular contractility (during both systole and diastole). Other echocardiographic parameters of regional left ventricular function changed with only low-grade significance or without any significance at all. During and after infusion of adrenaline, the horses showed sweating, muscle tremor and other symptoms of discomfort. The study revealed that the increases in heart rate and myocardial contractility after infusion of adrenaline were low compared with changes observed during physical performance. Furthermore, severe adverse effects were observed. Taking into account the possible cardiotoxic effects of adrenaline, we do not consider this method appropriate for stress induction, particularly in horses with cardiac disorders.

Keywords

equinecatecholaminestress echocardiography
Type
Research Article
Information
Equine and Comparative Exercise Physiology , Volume 2 , Issue 2 , May 2005 , pp. 89 - 96
Copyright
Copyright © Cambridge University Press 2005

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References

1Moltzahn, S and Zeydabadinejad, M (1996). Stressechokar-diographie: Eine Einführung 14 Aufl. Stuttgart: Georg Thieme Verlag, pp. 60–107.Google Scholar
2Marcovitz, PA and Armstrong, WF (1991) Dobutamine stress echocardiography: diagnotic utility. Herz 16: 372–378.Google Scholar
3Sawada, SG, Segar, DS, Ryan, T, Brown, SE, Dohan, AM, Williams, R et al. (1991) Echocardiographic detection of coronary artery disease during dobutamine infusion. Circulation 83: 1605–1614.CrossRefGoogle ScholarPubMed
4Segar, DS, Brown, SE, Sawada, SG, Ryan, T and Feigenbaum, H (1992) Dobutamine stress echocardiography: correlation with coronary lesion as determined by quantitative angiography. Journal of the American College of Cardiology 19: 1197–1202.Google Scholar
5Previtali, M, Lanzarini, L, Fetiveau, R, Poli, A, Ferrario, M, Falcone, C et al. (1993) Comparison of dobutamine stress echocardiography, dipyridamole stress echocardiography and exercise stress testing for diagnosis of coronary artery disease. American Journal of Cardiology 72: 865–870.CrossRefGoogle ScholarPubMed
6Fioretti, PM, Poldermans, D, Salustri, A, Forster, T, Bellotti, P, Boersma, E et al. (1994) Atropine increases the accuracy of dobutamine stress echocardiography in patients taking β-blockers. European Heart Journal 15: 355–360.CrossRefGoogle ScholarPubMed
7Schröder, K, Kürsten, R, Dissmann, N and Schultheiss, HP (1996) A new dobutamine–atropine stress echocardiography protocol: feasibility, accuracy and safety. Journal of the American Society of Echocardiography 9: 398 [abstract].Google Scholar
8Hoffmann, R (2002). Stressechokardiographie zur Ischämie-diagnostik. In: Flachskampf, FA (ed.), Praxis der Echokardiographie 1 Aufl. Stuttgart: Georg Thieme Verlag, pp. 183–203.Google Scholar
9Trakhtenbroit, AD, Cheirif, J, Kleiman, N, Verani, MS and Zoghbi, WA (1990) Adenosine echocardiography in the diagnosis of coronary heart disease: comparison with coronary angiography. Circulation 82 (Suppl. III): 193A.Google Scholar
10Gehlen, H, Becker, J, Deegen, E and Stadler, P (2004) Veränderung echokardiographischer Funktionsparameter unter Dobutaminwirkung bei Warmblutpferden mit und ohne Herzgeräusch. Vet Med Austria 91: 103–111.Google Scholar
11Wyss, A (1999). Veränderung der Verkürzungsfraktion von gesunden Pferdeherzen unter der Stimulation von Dobutamin und Denopamin. Thesis, Veterinär-Medizinische Fakultät der Universität Bern, Bern, pp. 37–48.Google Scholar
12McEntee, K, Clercx, C, Soyeur, D, Amory, H, Michaux, C, Flandre, H et al. (2000) Usefulness of dobutamine stress tests for detection of cardiac abnormalities in dogs with experimentally induced early left ventricular dysfunction. American Journal of Veterinary Research 62: 448–455.CrossRefGoogle Scholar
13Frye, MA, Bright, JM, Dargatz, DA, Fettman, MJ, Frisbie, DD, Baker, DC et al. (2003) A comparison of dobutamine infusion to exercise as a cardiac stress test in healthy horses. Journal of Veterinary Internal Medicine 17: 58–64.CrossRefGoogle ScholarPubMed
14Löscher, W (2002) Pharmakologie des vegetativen (autono men) Nervensystems. In: Frey, HH & Löscher, W (eds), Lehrbuch der pharmakologie und Toxikologie für die Veteri närmedizin 2 Aufl. Enke Verlag: Stuttgart, pp. 79–138.Google Scholar
15Jänig, W (2000) Vegetatives Nervensystem. In: Schmidt, RF, Thews, G & Lang, F (eds), Physiologie des Menschen 28 Aufl. Berlin/Heidelberg/New York: Springer-Verlag, pp. 448–471.Google Scholar
16Starke, K and Freiburg, I (1992). Grundlagen der Pharma-kologie des Nervensystems. In: Forth, W, Henschler, D & Rummel, W (eds), Pharmakologie und Toxikologie 6 Aufl. Mannheim/Leipzig/Wien: BI-Wissenschaftsverlag, p. 153.Google Scholar
17Williams, RJ, Marlin, DJ, Smith, N, Harris, RC, Haresign, W, Davies Morel, MC (2002) Effects of cool and hot humid environment conditions on neuroendocrine responses of horses to treadmill exercise. Veterinary Journal 164: 54–63.CrossRefGoogle ScholarPubMed
18Otto, K (1986) Treatment of heart arrest by endotracheal administration of adrenaline in the horse. Deutsche tierärztliche Wochenschrift 93: 490–491.Google ScholarPubMed
19Palm, D, Hellenbrecht, D and Quiring, K (1992). Pharmako-logie noradrenerger und adrenerger Systeme. In: Forth, W, Henschler, D & Rummel, W (eds), Pharmakologie und Toxikologie 6 Aufl. Mannheim/Leipzig/Wien: BI-Wissens-chaftsverlag, pp. 96–109.Google Scholar
20Starke, K and Palm, D (1992). Pharmakologie noradrenerger und adrenerger Systeme. In: Forth, W, Henschler, D & Rummel, W (eds), Pharmakologie und Toxikologie 6 Aufl. Mannheim/Leipzig/Wien: BI-Wissenschaftsverlag, p. 169.Google Scholar
21Kraupp, O, Raberger, G and Schütz, W (1992). Pharmakodyna-mische Beeinflussung von Rhytmik Kontraktion und Durch-blutung des Herzens. In: Forth, W, Henschler, D & Rummel, W (eds), Pharmakologie und Toxikologie 6 Aufl. Mannheim/Leipzig/Wien: BI-Wissenschaftsverlag, pp. 345–409.Google Scholar
22Snow, DH (1979) Metabolic and physiological effects of adrenoceptor agonists and antagonist in the horse. Research in Veterinary Science 27: 372–378.CrossRefGoogle ScholarPubMed
23Haug, G and Lang, G (1998). Kontraindikationen, Nebenwir-kungen und Abbruchkriterien stressechokardiographischer Routinetechniken. In: Haug, G (ed.), Stressechokardio-graphie Darmstadt: Dr Dietrich Steinkopff Verlag GmbH & Co KG, pp. 199–213.Google Scholar
24Stadler, P, D'Agostino, U and Deegen, E (1988) Methodik der Schnittbildechokardiographie beim Pferd. Pferdeheilkunde 4: 161–174.CrossRefGoogle Scholar
25Patteson, MW, Gibbs, C, Wotton, PR and Cripps, PJ (1995) Echocardiographic measurements of cardiac dimensions and indices of cardiac function in normal adult Thoroughbred horses. Equine Veterinary Journal Supplement 19: 18–27.CrossRefGoogle Scholar
26Stadler, P, Rewel, A and Deegen, E (1993) Die M-Mode Echokardiographie bei S-Dressur-, S-Springpferden und bei untrainierten Pferden. J Vet Med A 40: 292–306.CrossRefGoogle Scholar
27Long, KJ (1992) Two-dimensional and M-mode echocardiography. Equine Vet Ed 4: 303–310.CrossRefGoogle Scholar
28Long, KJ, Bonagura, JD and Darke, GP (1992) Standardised imaging technique for guided M-mode and Doppler echocardiography in the horse. Equine Veterinary Journal 24: 226–235.CrossRefGoogle ScholarPubMed
29Blissit, KJ and Bonagura, JD (1995) Pulsed wave Doppler echocardiography in normal horses. Equine Veterinary Journal Supplement 19: 38–46.Google Scholar
30Gehlen, H, Stadler, P and Deegen, E (1998) Vorschlag zur Standardisierung der Untersuchung von herzkranken Warmblutpferden mit einem kardiologischen Beurteilungssystem. Pferdeheilkunde 14: 107–114.CrossRefGoogle Scholar
31Kritz, NG, Hodgson, DR and Roose, RJ (2000) Prevalence and clinical importance of heart murmur in racehorses. Journal of the American Veterinary Medical Association 216: 1441–1445.Google Scholar
32Holmes, JR (1968) The equine heart: problems and difficulties in assessing cardiac function on clinical examination. Equine Veterinary Journal 1: 10–18.CrossRefGoogle Scholar
33Reef, VB (2001) Stress echocardiography and its role in performance assessment. Equine Practice 17: 179–189.Google ScholarPubMed
34Snow, DH, Harris, RC, MacDonald, IA, Forster, CD and Marlin, DJ (1992) Effects of high-intensity exercise on plasma catecholamines in the Thoroughbred horse. Equine Veterinary Journal 24: 462–467.CrossRefGoogle ScholarPubMed
35Nagata, S, Takeda, F, Kurosawa, M, Mima, K, Hiraga, A, Kai, M et al. (1999) Plasma adrenocorticotropin, cortisol and catecholamines response to various exercise. Equine Veterinary Journal Supplement 30: 570–574.CrossRefGoogle Scholar
36Reef, VB, Maxson, AD and Lewis, M (1994) Echocardiographic and ECG changes in horses following exercise. Proceedings of the American College of Veterinary Internal Medicine 256–258.Google Scholar
37Aitken, MM and Sanford, J (1972) Effects of tranquillizers on tachycardia induced by adrenaline in the horse. British Veterinary Journal 128: vii–vix.Google ScholarPubMed
38Venner, M, Furkert-Korsa, B and Deegen, E (2001) Zur Wirkung von Adrenalin auf die Milzgröβe beim Pferd. Pferdeheilkunde 17: 135–140.Google Scholar
39Anderson, MG and Aitken, MM (1977) Biochemical and physiological effects of catecholamine administration in the horse. Research in Veterinary Science 22: 357–360.Google Scholar
40Art, T, Amory, H, Desmecht, D and Lekeux, P (1990) Effect of show jumping on heart rate, blood lactate and other plasma biochemical values. Equine Veterinary Journal Supplement 9: 78–82.CrossRefGoogle Scholar
41Schöneseifen, N (2000). Untersuchungen zu Ausfällen bei Reitpferden sowie Belastung und Beanspruchung von Dressurpferden im Training. Dissertation. Fakultät für Landwirtschaft, Bonn, pp. 23–56.Google Scholar
42Marlin, DJ, Schroter, RC, Scott, CM, White, S, Nyrop, KA, Maykuth, PL et al. (1999) Sweating and skin temperature responses of normal and anhidrotic horses to intravenous adrenaline. Equine Veterinary Journal Supplement 30: 362–369.CrossRefGoogle Scholar
43Scott, CM, Marlin, DJ and Schroter, RC (2001) Quantification of the response of equine apocrine sweat glands to β 2 -adrenergic stimulation. Equine Veterinary Journal 33: 605–612.Google Scholar
44Gaynor, JS, Bednarski, RM, Muir, WW 3rd (1993) Effect of hypercapnia on the arrhythmogenic dose of epinephrine in horses anesthetized with guaifenesin, thiamylal sodium, and halothane. American Journal of Veterinary Research 54: 315–321.CrossRefGoogle ScholarPubMed
45Gaynor, JS, Bednarski, RM, Muir, WW 3rd (1992) Effect of xylazine on the arrhythmogenic dose of epinephrine in thiamylal/halothane-anesthetized horses. American Journal of Veterinary Research 53: 2350–2354.CrossRefGoogle ScholarPubMed
46Malone, ED, Brown, DR, Trent, AM and Turner, TA (1996) Influence of adrenergic and cholinergic mediators on the equine jejunum in vitro. American Journal of Veterinary Research 57: 884–890.CrossRefGoogle ScholarPubMed
47Carlsten, JC (1987) Two-dimensional, real-time echocardiography in the horse. Veterinary Radiology 28: 76–87.CrossRefGoogle Scholar
48Voros, K, Holmes, JR and Gibbs, C (1991) Measurement of cardiac dimension with two-dimensional echocardiography in the living horse. Equine Veterinary Journal 23: 461–465.Google Scholar
49Stadler, P and Robine, F (1996) Die Kardiometrie beim gesunden Warmblutpferd mit Hilfe der Schnittbildechokardiographie im B-Mode. Pferdeheilkunde 12: 35–43.CrossRefGoogle Scholar
50Harmeyer, J (2000). Herz. In: Engelhardt, WW & Breves, G (eds), Physiologie der Haustiere 1 Aufl. Stuttgart: Enke im Hippokrates Verlag GmbH, pp. 136–157.Google Scholar
51Silbernagel, S and Despopoulos, A (2001). Taschenatlas der Physiologie 5 Aufl. München: Georg Thieme Verlag Stuttgart und Deutscher Taschenbuch Verlag GmbH & Co KG, pp. 194–204.Google Scholar
52Antoni, H Mechanik der Herzaktion. In: Schmidt, RF, Thews, G & Lang, F (eds), Physiologie des Menschen 28 Aufl. Berlin/Heidelberg/New York: Springer-Verlag, pp. 448–471.Google Scholar
53Flachskampf, FA (2001). Kursbuch der Echokardiographie, pp. 71–93. Stuttgart/New York: Georg Thieme Verlag.Google Scholar
54Bartel, TH and Erbel, R (2002). Regionale und globale Funktion des linken Ventrikels bei koronarer Herzkrankheit. In: Flachskampf, F (ed.), Praxis der Echokardiographie Stuttgart: Georg Thieme Verlag, pp. 154–163.Google Scholar