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Effect of training and recovery on airway inflammation in an animal model of ‘ski asthma’

Published online by Cambridge University Press:  09 March 2007

MS Davis ,
EC McKenzie ,
CM Royer ,
KK Williamson ,
M Payton  and
SL Nelson
MS Davis*
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater OK 74078, USA
EC McKenzie
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater OK 74078, USA
CM Royer
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater OK 74078, USA
KK Williamson
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater OK 74078, USA
M Payton
Affiliation:
Department of Statistics, College of Arts and Sciences, Oklahoma State University, Stillwater OK 74078, USA
SL Nelson
Affiliation:
Iditarod Trail Committee, Wasilla AK 99786, USA
*
*[email protected]
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Abstract

Repeated strenuous exercise while breathing cold air is believed to induce chronic airway inflammation and hyperreactivity, a condition referred to in humans as ‘ski asthma’. However, the time course of development and resolution of ski asthma is unknown. We have previously shown that multi-day aerobic exercise induces airway inflammation and hyperreactivity in racing sled dogs. In the present study, a similar group of subjects was examined at multiple times during training to test the hypothesis that ski asthma spontaneously resolves during seasonal detraining, but is re-induced during training in the cold weather. At the beginning of training, bronchoalveolar lavage fluid (BALF) from detrained elite sled dogs (n = 16) had higher concentrations of lymphocytes (median 53.63 vs. 8.30 cells μl−1) and neutrophils (median 23.03 vs. 1.10 cells μl−1) compared with normal laboratory dogs (n = 5). However, there was no significant effect of training on BALF nucleated cell concentrations from exercised sled dogs (n = 11) compared with sedentary sled dogs (n = 8). In contrast to our hypothesis, our data support the contention that cold weather exercise-induced airway inflammation can persist through seasonal detraining, but that routine training does not cause significant worsening of the condition.

Keywords

Exercisebronchitissled dog
Type
Research Article
Information
Equine and Comparative Exercise Physiology , Volume 2 , Issue 2 , May 2005 , pp. 133 - 138
Copyright
Copyright © Cambridge University Press 2005

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References

1Karjalainen, EM, Laitinen, A, Sue-Chu, M, Altraja, A, Bjermer, L and Laitinen, LA (2000). Evidence of airway inflammation and remodeling in ski athletes with and without bronchial hyperresponsiveness to methacholine. American Journal of Respiratory and Critical Care Medicine 161: 2086–2091.CrossRefGoogle ScholarPubMed
2Sue-Chu, M, Henricksen, AH and Bjermer, L (1999). Non-invasive evaluation of lower airway inflammation in hyper-responsive elite cross-country skiers and asthmatics. Respiratory Medicine 93: 719–725.CrossRefGoogle ScholarPubMed
3Sue-Chu, M, Larsson, L, Moen, T, Rennard, SI and Bjermer, L (1999). Bronchscopy and bronchoalveolar lavage findings in cross-country skiers with and without “ski asthma”. European Respiratory Journal 13: 626–632.CrossRefGoogle Scholar
4Daviskas, E, Gonda, I and Anderson, SD (1991). Local airway heat and vapour losses. Respiration Physiology 84: 115–132.CrossRefGoogle ScholarPubMed
5Freed, AN (1995). Models and mechanisms of exercise-induced asthma. European Respiratory Journal 8: 1770–1785.CrossRefGoogle ScholarPubMed
6Davis, MS, McKiernan, BC, McCullough, S, Nelson, S, Mandsager, RE, Willard, M et al. (2002). Racing Alaskan sled dogs as a model of “ski asthma”. American Journal of Respiratory and Critical Care Medicine 166: 878–882.CrossRefGoogle Scholar
7Davis, MS, Schofield, B and Freed, AN (2003). Repeated peripheral airway hyperpnea causes inflammation and remodeling in dogs. Medicine and Science in Sports and Exercise 35: 608–616.CrossRefGoogle ScholarPubMed
8Davis, MS and Freed, AN (1999). Repetitive hyperventilation causes peripheral airway obstruction and eosinophilia. European Respiratory Journal 14: 57–62.CrossRefGoogle ScholarPubMed
9Davis, MS and Freed, AN (2001). Repeated hyperventilation causes peripheral airways inflammation, hyperreactivity, and impaired bronchodilation in dogs. American Journal of Respiratory and Critical Care Medicine 164: 785–789.CrossRefGoogle ScholarPubMed
10Davis, M, Williamson, K, McKenzie, E, Royer, C, Payton, M and Nelson, S (2005). Effect of training and rest on respiratory mechanical properties in racing sled dogs. Medicine and Science in Sports and Exercise 37: 337–341.CrossRefGoogle ScholarPubMed
11Daviskas, E, Gonda, I and Anderson, SD (1990). Mathematical modeling of heat and water transport in human respiratory tract. Journal of Applied Physiology 69: 362–372.CrossRefGoogle ScholarPubMed
12Hashimoto, S, Matsumoto, K, Gon, Y, Nakayama, T, Takeshita, I and Horie, T (1999). Hyperosmolarity-induced interleukin-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase. American Journal of Respiratory and Critical Care Medicine 159: 634–640.CrossRefGoogle ScholarPubMed
13Hashimoto, S, Gon, Y, Matsumoto, K, Takeshita, I, Maruoka, S and Horie, T (2000). Inhalant corticosteroids inhibit hyperosmolarity-induced, and cooling and rewarming-induced interleukin-8 and RANTES production by human bronchial epithelial cells. American Journal of Respiratory and Critical Care Medicine 162: 1075–1080.CrossRefGoogle ScholarPubMed
14Eggleston, PA, Kagey-Sobotka, A, Schleimer, RP and Lichtenstein, LM (1984). Interaction between hyperosmolar and IgE-mediated histamine release from basophils and mast cells. American Revision of Respiratory Diseases 130: 86–91.Google ScholarPubMed
15Omori, C, Schofield, BH, Mitzner, W and Freed, AN (1995). Hyperpnea with dry air causes time-dependent alterations in mucosal morphology and bronchovascular permeability. Journal of Applied Physiology 78: 1043–1051.CrossRefGoogle ScholarPubMed
16Clercx, C, Peeters, D, Snaps, F, Hansen, P, McEntee, K, Detilleux, J et al. (2000). Eosinophilic bronchopneumopathy in dogs. Journal of Veterinary Internal Medicine 14: 282–291.CrossRefGoogle ScholarPubMed
17Sanchez, A, Couetil, LL, Ward, MP and Clark, SP (2005). Effect of airway disease on blood gas exchange in racehorses. Journal of Veterinary Internal Medicine 19: 87–92.CrossRefGoogle ScholarPubMed
18Hinchcliff, KW, Reinhart, GA, Burr, JR, Schreier, CJ and Swenson, RA (1997). Metabolizable energy intake and sustained energy expenditure of Alaskan sled dogs during heavy exertion in the cold. American Journal of Veterinary Research 58: 1457–1462.CrossRefGoogle ScholarPubMed
19Davis, MS, Royer, CM, Payton, ME and Buttress, B (2002). Modeling the acute and late phase responses to peripheral airway cooling and desiccation. Journal of Applied Physiology 93: 195–200.CrossRefGoogle ScholarPubMed
20Larsson, K, Ohlsen, P, Larsson, L, Malmberg, P, Rydstrom, PO and Ulriksen, H (1993). High prevalence of asthma in cross country skiers. British Medical Journal 307: 1326–1329.CrossRefGoogle ScholarPubMed
21Wilber, RL, Rundell, KW, Szmedra, L, Jenkinson, DM, Im, J and Drake, SD (2000). Incidence of exercise-induced bronchospasm in Olympic winter sport athletes. Medicine and Science in Sports and Exercise 32: 732–737.CrossRefGoogle ScholarPubMed
22Eggelston, PA, Kagey-Sobotka, A and Lichtenstein, LM (1987). A comparison of the osmotic activation of basophils and human lung mast cells. American Revision of Respiratory Diseases 135: 1043–1048.Google Scholar
23Bradding, P, Roberts, JA, Britten, KM, Montefort, S, Djukanovic, R, Mueller, R et al. (1994). Interleukin-4, -5, and -6 and tumor necrosis factor-α in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. American Journal of Respiratory Cell and Molecular Biology 10: 471–480.CrossRefGoogle ScholarPubMed
24Bradding, P and Holgate, ST (1996). The mast cell as a source of cytokines in asthma. Annals of the New York Academy of Sciences 796: 272–281.CrossRefGoogle ScholarPubMed