Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-26T06:41:49.607Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of detomidine on postural sway in horses

Published online by Cambridge University Press:  09 March 2007

D Bialski ,
JL Lanovaz ,
GV Bohart ,
DR Mullineaux  and
HM Clayton
D Bialski
Affiliation:
Mary Anne McPhail Equine Performance Center, Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
JL Lanovaz
Affiliation:
Mary Anne McPhail Equine Performance Center, Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
GV Bohart
Affiliation:
Mary Anne McPhail Equine Performance Center, Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
DR Mullineaux
Affiliation:
Mary Anne McPhail Equine Performance Center, Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
HM Clayton*
Affiliation:
Mary Anne McPhail Equine Performance Center, Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
*
*[email protected]
Get access

Abstract

The objective of this study was to apply postural sway analysis to measure balance deficits after intravenous administration of detomidine. Six healthy horses were treated intravenously with detomidine (10 μg kg−1, 20 μgkg−1) and saline in random order, with three days between treatments. Postural sway was measured immediately after administration and at 15 min intervals until 120 min had elapsed. Horses stood squarely with all four hooves on a force platform, while the location of the centre of pressure (COP) was recorded continuously for 10 s at 1000 Hz. Five 10 s recordings were analysed and average values calculated for mediolateral COP range of motion, craniocaudal COP range of motion, mean COP radius, COP area and mean COP velocity. All COP variables increased immediately after sedation, but generally returned to normal limits within 15 and 30 min of detomidine administration at 10 and 20 μg kg−1, respectively. The head was lowered for at least 90 min after administration. Balance is affected by detomidine and normal balance is regained later after a higher dose. Procedures requiring balance should not be performed within 15–30 min of detomidine administration. COP variables are a good indicator of the effect of sedation on postural sway, but head position is not.

Keywords

balanceposturestabilitysedation
Type
Research Article
Information
Equine and Comparative Exercise Physiology , Volume 1 , Issue 1 , February 2004 , pp. 45 - 50
Copyright
Copyright © Cambridge University Press 2004

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Fung, J and Macpherson, JM (1995). Determinants of postural orientation in quadrupedal stance. Journal of Neuroscience 15: 1121–1131.CrossRefGoogle ScholarPubMed
2Woollacott, M and Shumway-Cook, A (2002). Attention and the control of posture and gait: a review of an emerging area of research. Gait and Posture 16: 1–14.CrossRefGoogle Scholar
3Sveistrup, H and Woollacott, M (1996). Longitudinal development of the automatic postural response in infants associated with developmental transitions in balance abilities. Journal of Motor Behaviour 28: 58–70.CrossRefGoogle Scholar
4Panzer, VP, Bandinelli, S and Hallett, M (1995). Biomechanical assessment of quiet standing and changes associated with aging. Archives of Physical Medicine and Rehabilitation 76: 151–157.CrossRefGoogle ScholarPubMed
5Mesure, S, Azulay, JP, Pouget, J and Amblard, B (1999). Strategies of segmental stabilization during gait in Parkinson's disease. Experimental Brain Research 129: 573–581.CrossRefGoogle ScholarPubMed
6Smith, LB, Bhattacharya, A, Lemasters, G, Succop, P, Puhala, E, Medvedovic, M, et al. (1997). Effect of chronic low-level exposure to jet fuel on postural balance of US Air Force personnel. Journal of Occupational and Environmental Medicine 39: 623–632.CrossRefGoogle ScholarPubMed
7Massion, J, Amblard, B, Assaiante, C, Mouchnino, L and Vernazza, S (1998). Body orientation and control of coordinated movements in microgravity. Brain Research Reviews 28: 83–91.CrossRefGoogle ScholarPubMed
8Barberini, CL and Macpherson, JM (1998). Effect of head on postural orientation and equilibrium. Experimental Brain Research 122: 175–184.CrossRefGoogle ScholarPubMed
9Clayton, HM, Schott, HC, Littlefield, L and Lanovaz, JL (1999). Centre of pressure analysis in normal and neurological horses. Journal of Veterinary Internal Medicine 13: 241 (abstract).Google Scholar
10Clayton, HM, Bialski, DM, Lanovaz, JL and Mullineaux, DR (2003). Reliability of a technique to measure postural sway in horses. American Journal of Veterinary Research 64: 1354–1359.CrossRefGoogle ScholarPubMed
11Paulus, W, Straube, A and Brandt, TH (1987). Visual postural performance after loss of somatosensory and vestibular function. Journal of Neurology, Neurosurgery and Psychology 51: 1542–1545.CrossRefGoogle Scholar
12England, G.C.W., Clarke, KW and Goosens, L (1992). A comparison of the sedative effects of three α2-adrenoceptor agonists (romifidine, detomidine and xylazine) in the horse. Journal of Veterinary Pharmacology and Therapeutics 15: 194–201.CrossRefGoogle Scholar
13Hamm, D, Turchi, P and Jöchle, W (1995). Sedative and analgesic effects of detomidine and romifidine in horses. Veterinary Record 136: 324–327.CrossRefGoogle ScholarPubMed
14Jöchle, W and Hamm, D (1986). Sedation and analgesia with Dormosedan® (detomidine hydrochloride) in horses: dose response studies on efficacy and its duration. Acta Veterinaria Scandinavica 82: 69–84.Google ScholarPubMed
15Szeligowski, E, Janicki, AM and Krzeski, M (1986). Detomidine (Domosedan®) in sedation, premedication and general anaesthesia of horses. Acta Veterinaria Scandinavica 82: 181–185.Google ScholarPubMed
16Ricketts, SW (1986). Clinical experiences with Domosedan in equine practice in Newmarket. Acta Veterinaria Scandinavica 82 (Suppl.), 197–201.Google ScholarPubMed
17Abdel-Aziz, YI and Karara, HM (1971). Direct linear transformation from computer coordinates into object coordinates in close-range photogrammetry. In: American Society of Photogrammetry, Falls Church, VA. Proceedings of Symposium on Close-Range Photogrammetry pp. 1–19.Google Scholar
18Mullineaux, DR, Barnes, CA and Batterham, AM (1999). Assessment of bias in comparing measurements: a reliability example. Measurements in Physical Exercise and Science 3: 195–205.CrossRefGoogle Scholar
19Bland, JM (2000). An Introduction to Medical Statistics Oxford: Oxford University Press.Google Scholar
20Le Clair, K and Riach, C (1996). Postural stability measures: what to measure and for how long. Clinical Biomechanics 11: 176–178.CrossRefGoogle ScholarPubMed
21Collins, JJ and De Luca, CJ (1993). Open-loop and closed-loop control of posture: a random-walk analysis of centre-of-pressure trajectories. Experimental Brain Research 95: 308–318.CrossRefGoogle Scholar
22Jeka, JJ and Lackner, JR (1994). Fingertip contact influences human postural control. Experimental Brain Research 100: 495–502.CrossRefGoogle ScholarPubMed
23Fitzpatrick, R and McCloskey, DI (1994). Proprioceptive, visual and vestibular thresholds for perception of sway during standing in humans. Journal of Physiology 478: 173–186.CrossRefGoogle ScholarPubMed
24Jöchle, W (1984). Domosedan: a new sedative and analgesic drug for horses with dose-dependent duration of effects: an introduction. Proceedings of the American Association of Equine Practitioners 30: 221–224.Google Scholar