Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-22T17:50:07.387Z Has data issue: false hasContentIssue false
  • English
  • Français

Acute vascular occlusion in horses: effects on skeletal muscle size and blood flow

Published online by Cambridge University Press:  09 March 2007

T Abe ,
CF Kearns ,
HC Manso Filho ,
Y Sato ,
M Sleeper  and
KH McKeever
T Abe*
Affiliation:
Department of Exercise and Sport Science, Tokyo Metropolitan University, 1-1 Minami-Ohsawa, Hachioji, Tokyo, 192-0397, Japan
CF Kearns
Affiliation:
Cardiovascular/Endocrine Biology, Schering-Plough Research Institute, Kenilworth, NJ, USA
HC Manso Filho
Affiliation:
Equine Science Center, Department of Animal Sciences, Cook College, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
Y Sato
Affiliation:
Sato Institute for Rehabilitation and Fitness, Fuchu, Tokyo, Japan
M Sleeper
Affiliation:
Ryan Veterinary Hospital, University of Pennsylvania, Philadelphia, PA, USA
KH McKeever
Affiliation:
Equine Science Center, Department of Animal Sciences, Cook College, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
*
Email:[email protected]
Get access

Abstract

The purpose of this study was to demonstrate whether acute vascular occlusion was safe and if it would result in changes to limb muscle size in horses. Six healthy, unfit Standardbred mares were used. Horses (standing at rest) wore an occlusion cuff at the most proximal position of the left forelimb. The right forelimb was used as control. An occlusion pressure of 200 mmHg was set for 5 min followed by a 2 min recovery. Three sets of occlusions were given to each horse. Muscle thickness was measured using B-mode ultrasound. The circumference of the forelimb and first phalanx was measured using a flexible tape measure. Pulsed-wave Doppler was performed on the radialis artery with a 5–10 MHz mechanical transducer at baseline and at each occlusion. Peak flow velocity (PFV) and the flow velocity integral (FVI) were measured each time. Mid-forelimb, but not first phalanx, girth was increased (P<0.05) in the occluded but not in the control leg following occlusion. Extensor and flexor muscle thickness was increased (P<0.05) in the occluded but not in the control leg. There were no changes (P>0.05) in PFV or FVI at any measurement time point. Acute vascular occlusion may be a suitable and safe model for studying muscle hypertrophy in horses.

Keywords

muscle thicknessplasma lactatepacked cell volumeKaatsu-training
Type
Short Communication
Information
Equine and Comparative Exercise Physiology , Volume 1 , Issue 4 , November 2004 , pp. 239 - 243
Copyright
Copyright © Cambridge University Press 2004

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Takarada, Y, Nakamura, Y, Aruga, S, Onda, T, Miyazaki, S and Ishii, N (2000). Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion. Journal of Applied Physiology 88: 61–65.CrossRefGoogle ScholarPubMed
2Takarada, Y, Takazawa, H and Ishii, N (2000). Applications of vascular occlusion diminish disuse atrophy of knee extensor muscles. Medicine and Science in Sports and Exercise 32: 2035–2039.CrossRefGoogle ScholarPubMed
3Abe, T, Midorikawa, T, Yasuda, T, Sato, Y, Ishii, N and Madarame, H (2003). Effects of low-intensity ‘Kaatsu’ resistance training on muscle size (in Japanese) In: Proceedings of the 16th Scientific Congress for Sports and Exercise Training Hiroshima. Japan: Yasuda Women's University, Japan P.16.Google Scholar
4Kearns, CF, McKeever, HK, Kumagai, K and Abe, T (2002). Fat-free mass is related to one-mile race performance in elite Standardbred horses. The Vetenary Journal 163: 260–266.CrossRefGoogle ScholarPubMed
5Kearns, CF and McKeever, KH (2002). Clenbuterol diminishes aerobic performance in horses. Medicine and Science in Sports and Exercise 34: 1976–1985.CrossRefGoogle ScholarPubMed
6Pourcelot, L (1974). Applications cliniques de l'examen Doppler transcutane. In: Peronnequs, P (ed) Velecoimetrie ultrasonore Doppler Paris: INSERM pp. 780–785.Google Scholar
7Wolthuls, RA, Bergman, SA and Nicogossian, AE (1974). Physiological effects of locally applied reduced pressure in man. Physiological Review 54: 566–595.CrossRefGoogle Scholar
8Hood, DM, Grosenbaugh, DA, Mostafa, MB, Morgan, SJ and Thomas, BC (1993). The role of vascular mechanisms in the development of acute equine laminitis. Journal of Veterinary Internal Medicine 13: 240–242.Google Scholar
9Garner, HE, Hutcheson, DP, Coffman, JR, Hahn, AW and Salem, C (1977). Lactic acidosis: a factor associated with equine laminitis. Journal of Animal Science 45: 1037–1041.CrossRefGoogle ScholarPubMed
10Rowe, JB, Lees, MJ and Pethick, DW (1995). Prevention of acidosis and laminitis associated with grain feeding in horses. Journal of Nutrition 124 Suppl. 12 2742S – 2744SGoogle Scholar
11Persson, S (1967). On blood volume and working capacity in horses: studies of methodology and physiological and pathological variations. Acta Veterinaria Scandinavica 19: 9–189.Google Scholar