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Time to abandon the bio-bio-bio model of psychosis: Exploring the epigenetic and psychological mechanisms by which adverse life events lead to psychotic symptoms

Published online by Cambridge University Press:  11 April 2011

John Read ,
Richard P. Bentall  and
Roar Fosse
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Abstract

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Mental health services and research have been dominated for several decades by a rather simplistic, reductionistic focus on biological phenomena, with minimal consideration of the social context within which genes and brains inevitably operate. This ‘medical model’ ideology, enthusiastically supported by the pharmaceutical industry, has been particularly powerful in the field of psychosis, where it has led to unjustified and damaging pessimism about recovery. The failure to find robust evidence of a genetic predisposition for psychosis in general, or ‘schizophrenia’ in particular, can be understood in terms of recently developed knowledge about how epigenetic processes turn gene transcription on and off through mechanisms that are highly influenced by the individual's socio-environmental experiences. To understand the emerging evidence of the relationship between adverse childhood events and subsequent psychosis, it is necessary to integrate these epigenetic processes, especially those involving the stress regulating functions of the HPA axis, with research about the psychological mechanisms by which specific types of childhood trauma can lead to specific types of psychotic experiences. The implications, for research, mental health services and primary prevention, are profound.

Declaration of Interest: None of the authors have any conflicts of interest in relation to this paper.

Keywords

sexual abuse in childhoodpsychosismechanism of psychiatric symptoms
Type
Editorials
Information
Epidemiology and Psychiatric Sciences , Volume 18 , Issue 4 , December 2009 , pp. 299 - 310
Copyright
Copyright © Cambridge University Press 2010

References

REFERENCES

Alanen, Y. (2009). Towards a more humanistic psychiatry: Development of need-adapted treatment of schizophrenia group psychoses. Psychosis: Psychological, Social and Integrative Approaches 1, 156–166.CrossRefGoogle Scholar
Angermeyer, M. & Matschinger, H. (2003). Public beliefs about schizophrenia and depression: similarities and differences. Social Psychiatry and Psychiatric Epidemiology 38, 526–534.CrossRefGoogle ScholarPubMed
Barkus, E., Stirling, J., Hopkins, R., McKie, S. & Lewis, S. (2007). Cognitive and neural processes in non-clinical auditory hallucinations. British Journal of Psychiatry 191, Suppl. 51, 76–81.Google Scholar
Bebbington, P., Bhugra, D., Brugha, T., Singleton, N., Farrell, M., Jenkins, R., Lewis, G. & Meltzer, H. (2004). Psychosis, victimization and childhood disadvantage: Evidence from the second British national survey on psychiatric morbidity. British Journal of Psychiatry 185, 220–226.Google Scholar
Bendall, S., Jackson, H., Hulbert, C. & McGorry, P. (2008). Childhood trauma and psychotic disorders: a systematic, critical review of the evidence. Schizophrenia Bulletin 34, 569–579.Google Scholar
Benes, F. & Berretta, S. (2001). GABAergic interneurons: Implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology 25, 1–27.CrossRefGoogle ScholarPubMed
Bentall, R. (1990). The illusion of reality: a review and integration of psychological research on hallucinations. Psychological Bulletin 107, 82–95.Google Scholar
Bentall, R. (2003). Madness Explained: Psychosis and Human Nature. Penguin: London.Google Scholar
Bentall, R. (2009). Doctoring the Mind: Why Psychiatric Treatments are Often Ineffective. Penguin: London.Google Scholar
Bentall, R. & Fernyhough, C. (2008). Social predictors of psychotic experiences: Specificity and psychological mechanisms. Schizophrenia Bulletin 34, 1012–1020Google Scholar
Bentall, R. & Slade, P. (1985). Reality testing and auditory hallucinations: a signal-detection analysis. British Journal of Clinical Psychology 24, 159–169.CrossRefGoogle ScholarPubMed
Bentall, R., Baker, G.A. & Havers, S. (1991). Reality monitoring and psychotic hallucinations. British Journal of Clinical Psychology 30, 213–222.Google Scholar
Bentall, R., Kinderman, P. & Kaney, S. (1994). The self, attributional processes and abnormal beliefs: towards a model of persecutory delusions. Behaviour Research and Therapy 32, 331–341.Google Scholar
Bentall, R., Corcoran, R., Howard, R., Blackwood, N. & Kinderman, P. (2001). Persecutory delusions: a review and theoretical integration. Clinical Psychology Review 21, 1143–1192.CrossRefGoogle ScholarPubMed
Bentall, R., Rowse, G., Shryane, N., Kinderman, P., Howard, R., Blackwood, N., Moore, R. & Corcoran, R. (2009). The cognitive and affective structure of paranoid delusions: a transdiagnostic investigation of patients with schizophrenia spectrum disorders and depression. Archives of General Psychiatry 66, 236–247.Google Scholar
Berk, L. (1994). Why children talk to themselves. Scientific American 61–65.Google Scholar
Bola, J., Lehtinen, K., Cullberg, J. & Ciompi, L. (2009). Psychosocial treatment, antipsychotic postponement, and low-dose medication strategies in first-episode psychosis: a review of the literature. Psychosis: Psychological, Social and Integrative Approaches 1, 4–18.Google Scholar
Braehler, C., Holowka, D., Brunet, A., Beaulieu, S., Baptista, T., Bebruille, J-M., Walker, C. & King, S. (2005). Diurnal cortisol in schizophrenia patients with childhood trauma. Schizophrenia Research 79, 353–354.Google Scholar
Brebion, G., Amador, X., David, A., Malaspina, D. & Sharif, Z. (2000). Positive symptomatology and source monitoring failure in schizophrenia: an analysis of symptom-specific effects. Psychiatry Research 95, 119–131.CrossRefGoogle ScholarPubMed
Brune, M. (2005). Theory of mind' in schizophrenia: a review of the literature. Schizophrenia Bulletin 31, 21–42.Google Scholar
Champagne, F. & Curley, J. (2009). Epigenetic mechanisms mediating the long-term effects of maternal care on development. Neuroscience and Biobehavioral Reviews 33, 593–600.Google Scholar
Conus, P., Cotton, S., Schimmelmann, B., McGorry, P. & Lambert, M. (2009). Pretreatment and outcome correlates of sexual and physical trauma in an epidemiological cohort of first-episode psychosis patients. Schizophrenia Bulletin, april 21 [Epub ahead of print].Google Scholar
Corbin, J., (2007). Reactive attachment disorder: a biopsychosocial disturbance of attachment. Child and Adolescent Social Work Journal 24, 539–552.Google Scholar
Corcoran, R., Cahill, C. & Frith, C. (1997). The appreciation of visual jokes in people with schizophrenia: a study of ‘mentalizing’ ability. Schizophrenia Research 24, 319–327.CrossRefGoogle ScholarPubMed
Corcoran, R., Rowse, G., Moore, R., Blackwood, N., Kinderman, P., Howard, R., Cummins, S. & Bentall, R. (2008). A transdiagnostic investigation of theory of mind and jumping to conclusions in paranoia: a comparison of schizophrenia and depression with and without delusions. Psychological Medicine 38, 1577–1583.CrossRefGoogle Scholar
Davies, E. & Burdett, J. (2004). Preventing ‘schizophrenia’: creating the conditions for saner societies. In Models of Madness (ed. Read, J., Mosher, L., Bentall, R.). Routledge: London.Google Scholar
Dozier, M. & Lee, S. (1995). Discrepancies between self and other-report of psychiatric symptomatology: Effects of dismissing attachment strategies. Development and Psychopathology 7, 217–226.Google Scholar
Drury, V., Robinson, E. & Birchwood, M. (1998). Theory of mind' skills during an acute episode of psychosis and following recovery. Psychological Medicine 28, 1101–1112.Google Scholar
Dudley, R. & Over, D. (2003). People with delusions jump to conclusions: a theoretical account of research findings on the reasoning of people with delusions. Clinical Psychology and Psychotherapy 10, 263–274.Google Scholar
Eaton, W. (1980). A formal theory of selection for schizophrenia. American Journal of Sociology 86, 149–158.Google Scholar
Faris, R. & Dunham, H. (1939). Mental Disorders in Urban Areas. University of Chicago: Chicago.Google Scholar
Fisher, H., Morgan, C., Dazzan, P., Craig, T., Morgan, K., Hutchinson, G., Jones, P., Doody, G., Pariante, C., McGuffin, P., Murray, R., Leff, J. & Fearon, P. (2009). Gender differences in the association between childhood abuse and psychosis. British Journal of Psychiatry 194, 319–325.Google Scholar
Fisher, H., Craig, T., Fearon, P., Dazzan, P., Lappin, J., Hutchinson, G., Doody, G., Jones, P., McGuffin, P., Murray, R., Leff, J. & Morgan, C. (in press). Reliability and validity of psychosis patients' retrospective reports of childhood abuse. Schizophrenia Bulletin.Google Scholar
Ford, J. & Mathalon, D. (2004). Electrophysiological evidence of corollary discharge dysfunction in schizophrenia during talking and thinking. Journal of Psychiatric Research 38, 37–46.Google Scholar
Fosse, R. (in press). Mot en ny forståelse av psykiske lidelser. Journal of the Norwegian Psychology Associaton.Google Scholar
Frith, C. (1994). Theory of mind in schizophrenia. In The Neuropsychology of Schizophrenia (ed. David, A. and Cutting, J.). Hove: Erlbaum.Google Scholar
Garety, P., Hemsley, D. & Wessely, S. (1991). Reasoning in deluded schizophrenic and paranoid patients. Journal of Nervous and Mental Disease 179, 194–201.CrossRefGoogle ScholarPubMed
Garety, P., Freeman, D., Jolley, S., Dunn, G., Bebbington, P., Fowler, D., Kuipers, E. & Dudley, R. (2005). Reasoning, emotions and delusional convictions in psychosis. Journal of Abnormal Psychology 114, 373–384.Google Scholar
Geekie, J. & Read, J. (2009). Making Sense of Psychosis: Contesting the Meaning of Schizophrenia. Routledge: London.CrossRefGoogle Scholar
Gleeson, J., Killackey, E. & Krstev, H. (Eds.) (2008). Psychotherapies for the Psychoses: Theoretical, Cultural and Clinical Integration. Routledge: London.Google Scholar
Gould, L. (1948). Verbal hallucinations and activity of vocal musculature. American Journal of Psychiatry 105, 367–372.Google Scholar
Goldstein, J., Seidma, L., Makris, N., Ahern, T., O'Brien, L., Caviness, V., Kennedy, D., Faraone, S. & Tsuang, M. (2007). Hypothalamic abnormalities in schizophrenia: sex effects and genetic vulnerability. Biological Psychiatry 61, 935–945CrossRefGoogle ScholarPubMed
Hamilton, S.P. (2008). Schizophrenia candidate genes: Are we really coming up blank? American Journal of Psychiatry 165, 420–423.CrossRefGoogle ScholarPubMed
Hammersley, P., Dias, A., Todd, G., Bowen-Jones, K., Reilly, B. & Bentall, R. (2003). Childhood trauma and hallucinations in bipolar affective disorder: a preliminary investigation. British Journal of Psychiatry 182, 543–547.Google Scholar
Harrison, G., Owens, D., Holton, A., Neilson, D. & Boot, D. (1988). A prospective study of severe mental disorder in Afro-Caribbean patients. Psychological Medicine 18, 643–657.CrossRefGoogle ScholarPubMed
Harrison, G., Gunnell, D., Glazebrook, C., Page, K. & Kwiecinski, R. (2001). Association between schizophrenia and social inequality at birth. British Journal of Psychiatry 179, 346–350.Google Scholar
Harrison, P. (2004). The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology (Berl) 174, 151–162.Google Scholar
Inouye, T. & Shimizu, A. (1970). The electromyographic study of verbal hallucination. Journal of Nervous and Mental Disease 151, 415–422.Google Scholar
Janssen, I., Hanssen, M., Bak, M., Bijl, R., De Graaf, R., Vollebergh, W. & van, Os. (2003). Discrimination and delusional ideation. British Journal of Psychiatry 182, 71–76.CrossRefGoogle ScholarPubMed
Janssen, I., Krabbendam, L., Bak, M., Hanssen, M., Vollebergh, W., de Graaf, R. & van Os, J. (2004). Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatrica Scandinavica 109, 38–45.Google Scholar
Janssen, I., Versmissen, D., Campo, J., Myin-Germeys, I., van Os, J. & Krabbendam, L. (2006). Attributional style and psychosis: evidence for externalizing bias in patients but not individuals at high risk. Psychological Medicine 27, 1–8.Google Scholar
Johns, L., Rossell, S., Frith, C., Ahmad, F., Hemsley, D., Kuipers, E. & McGuire, P. (2001). Verbal self-monitoring and auditory hallucinations in people with schizophrenia. Psychological Medicine 31, 705–715.CrossRefGoogle Scholar
Johnson, M., Hashtroudi, S. & Lindsay, D. (1993). Source monitoring. Psychological Bulletin 114, 3–28.Google Scholar
Johnstone, L. (2009). Controversial issues in trauma and psychosis. Psychosis: Psychological, Social and Integrative Approaches 1, 185–190.Google Scholar
Jolley, S., Garety, P., Bebbington, P., Dunn, G., Freeman, D., Kuipers, E., Fowler, D. & Hemsley, D. (2006). Attributional style in psychosis: the role of affect and belief type. Behaviour Research and Therapy 44, 1597–1607.CrossRefGoogle ScholarPubMed
Jones, S. & Fernyhough, C. (2007). Neural correlates of inner speech and auditory verbal hallucinations: a critical review and theoretical integration. Clinical Psychology Review 27, 140–154.Google Scholar
Joseph, J. (2006). The Missing Gene: Psychiatry, Heredity, and the Fruitless Search for Genes. Algora: New York.Google Scholar
Kilcommons, A., Morrison, A., Knight, A. & Lobban, F. (2008). Psychotic experiences in people who have been sexually assaulted. Social Psychiatry and Psychiatric Epidemiology 43, 902–611.CrossRefGoogle ScholarPubMed
Kingdon, D. & Turkington, D. (2005). Cognitive Therapy of Schizophrenia. Guilford Press: New York.Google Scholar
Larkin, W. & Morrison, A. (Eds.) (2006). Trauma and Psychosis: New Directions for Theory and Therapy. Routledge: London.Google Scholar
Larkin, W. & Read, J. (2008). Childhood trauma and psychosis: Evidence, pathways, and implications. Journal of Postgraduate Medicine 54, 284–290.Google ScholarPubMed
Laruelle, M., & Abi-Dargham, A. (1999). Dopamine as the wind in the psychotic fire: new evidence from brain imaging studies. Journal of Psychopharmacology 13, 358–371.Google Scholar
Lataster, T., van Os, J., Drukker, M., Henquet, C., Feron, E., Gunther, N. & Myin-Germeys, I. (2004). Childhood victimization and developmental expression of non-clinical delusional ideation and hallucinatory experiences. Social Psychiatry and Psychiatric Epidemiology 41, 423–428.Google Scholar
Lecomte, T., Spidel, A., Leclerc, C., MacEwan, W., Greaves, C. & Bentall, R. (2008). Predictors and profiles of treatment non-adherence and engagement in service problems in early psychosis. Schizophrenia Research 102, 295–302.Google Scholar
Lewis, G., David, A. & Andreasson, S. (1992). Schizophrenia and city life. Lancet 340, 137–140.CrossRefGoogle ScholarPubMed
Magliano, L., Fiorillo, A., Del Vecchio, H., Malangone, C., De Rosa, C., Bachelet, C., Truglia, E., D'Ambrogio, R., Pizzale, F., Veltro, F., Zanus, P., Pioli, R. & Maj, M. (2009). What people with schizophrenia think about the causes of their disorder. Epidemiologia e Psichiatria Sociale 18, 48–53.Google Scholar
McGuigan, F. (1966). Covert oral behavior and auditory hallucinations. Psychophysiology 3, 73–80.Google Scholar
McKay, R., Langdon, R., & Coltheart, M. (2007). The defensive function of persecutory delusions: an investigation using the implicit association test. Cognitive Neuropsychiatry 12, 1–24.CrossRefGoogle ScholarPubMed
Mirowsky, J. & Ross, C. (1983). Paranoia and the structure of power-lessness. American Sociological Review 48, 228–239.Google Scholar
Morgan, C. & Fearon, P. (2007). Social experience and psychosis. Insights from studies of migrant and ethnic minority groups. Epidemiologia e Psichiatria Sociale 16, 118–123.Google Scholar
Morgan, C. & Fisher, H. (2007). Environment and schizophrenia: environmental factors in schizophrenia: childhood trauma – a critical review. Schizophrenia Bulletin 33, 3–10.Google Scholar
Morgan, C., Kirkbride, J., Leff, J., Craig, T., Hutchinson, G., McKenzie, K., Morgan, K., Dazzan, P., Doody, G., Jones, P., Murray, R. & Fearon, P. (2007). Parental separation, loss and psychosis in different ethnic groups: a case-control study. Psychological Medicine 37, 495–503.Google Scholar
Moritz, S. & Woodward, T.S. (2005). Jumping to conclusions in delusional and non-delusional schizophrenic patients. British Journal of Clinical Psychology 44, 193–207.Google Scholar
Moritz, S., Werner, R. & von Collani, G. (2006). The inferiority complex in paranoia readdressed: a study with the Implicit Association Test. Cognitive Neuropsychiatry 11, 402–415.Google Scholar
Morrison, A. (2004). Cognitive Therapy for Psychosis: A Formulation-based Approach. Brunner-Routledge: Hove UK.Google Scholar
Morrison, A. (2009). Cognitive behaviour therapy for first-episode psychosis: Good for nothing or fit for purpose? Psychosis: Psychological, Social and Integrative Approaches 1, 103–112.CrossRefGoogle Scholar
Morrison, A. & Haddock, G. (1997). Cognitive factors in source monitoring and auditory hallucinations. Psychological Medicine 27, 669–679.Google Scholar
Mortensen, P., Pedersen, C., Westergaard, T., Wohlfahrt, J., Ewald, H., Mors, O., Andersen, P. & Melbye, M. (1999). Effects of family history and place and season of birth on the risk of schizophrenia. New England Journal of Medicine 340, 603–608.Google Scholar
Mosher, L., Gosden, R. & Beder, S. (2004). Drug companies and schizophrenia: Unbridled capitalism meets madness. In Models of Madness (ed. Read, J., Mosher, L., Bentall, R.). Routledge: London.Google Scholar
Moskowitz, A., Schafer, I. & Dorahy, M. (2009). Psychosis, Trauma and Dissociation: Emerging Perspectives on Severe Psychopathology. Wiley-Blackwell: Chichester, UK.Google Scholar
Moutoussis, M., Williams, J., Dayan, P. & Bentall, R. (2007). Persecutory delusions and the conditioned avoidance paradigm: towards an integration of the psychology and biology of paranoia. Cognitive Neuropsychiatry 12, 495–510.CrossRefGoogle ScholarPubMed
Myhrman, A., Rantakallio, P., Isohanni, M. & Jones, P. (1996). Unwantedness of pregnancy and schizophrenia in the child. British Journal of Psychiatry 169, 637–640.Google Scholar
Neil, S., Kilbride, M., Pitt, L., Nothard, S., Welford, M., Sellwood, W. & Morrison, A. (2009). The questionnaire about the process of recovery (QPR): A measurement tool developed in collaboration with service users. Psychosis: Psychological, Social and Integrative Approaches 1, 145–155.Google Scholar
Newcomer, J., Faustman, W., Whiteford, H., Moses, J. Jr & Csernansky, J. (1991). Symptomatology and cognitive impairment associate independently with post-dexamethasone cortisol concentrations in unmedicated schizophrenic patients. Biological Psychiatry 29, 855–864.CrossRefGoogle ScholarPubMed
Pariante, C.M. (2008). Pituitary volume in psychosis: the first review of the evidence. Journal of Psychopharmacology 22, 76–81Google Scholar
Pariante, C.M., Carmine, M., Dazzan, P., Danese, A., Morgan, K.D., Brudaglio, F., Morgan, C., Fearon, P., Orr, K., Hutchinson, G., Pantelis, C., Velakoulis, D., Jones, P.B., Left, J. & Murray, R.M. (2005). Increased pituitary volume in antipsychotic-free and antipsychotic-treated patients of the AEsop first-onset psychosis study. Neuropsychopharmacology 30, 1923–1931.CrossRefGoogle ScholarPubMed
Perlman, W., Webster, M., Kleinman, J. & Weickert, C. (2004). Reduced glucocorticoid and estrogen receptor-messenger ribonucleic acid levels in the amygdala of patients with major mental illness. Biological Psychiatry 56, 844–852Google Scholar
Pickering, L., Simpson, J. & Bentall, R. (2008). Insecure attachment predicts proneness to paranoia but not hallucinations. Personality and Individual Differences 44, 1212–1224.Google Scholar
Pruessner, J., Baldwin, M., Dedovic, K., Renwick, R., Mahani, N., Lord, C., Meaney, M. & Lupien, S. (2005). Self-esteem, locus of control, hip-pocampal volume, and cortisol regulation in young and old adulthood. Neuroimage 28, 815–826.Google Scholar
Raine, A., Mellingen, K., Liu, J., Venables, P. & Mednick, S. (2003). Effects of environmental enrichment at ages 3–5 years on schizotyp-al personality and antisocial behavior at ages 17 and 23 years. American Journal of Psychiatry 160, 1627–1635.Google Scholar
Rankin, P. & O'Carrol, P. (1995). Reality monitoring and signal detection in individuals prone to hallucinations. British Journal of Clinical Psychology 34, 517–528.CrossRefGoogle Scholar
Read, J. (2004a). Does schizophrenic exist? Reliability and validty. In Models of Madness: Psychological, Social and Biological Approaches to Schizophrenia (ed. Read, J., Mosher, L., Bentall, R.). Routledge: London.CrossRefGoogle Scholar
Read, J. (2004b). Poverty, ethnicity and gender. In Models of Madness: Psychological, Social and Biological Approaches to Schizophrenia (ed. Read, J., Mosher, L., Bentall, R.). Routledge: London.CrossRefGoogle Scholar
Read, J. (2007). Why promoting biological ideology increases prejudice against people labelled ‘schizophrenic’. Australian Psychologist 42, 118–128.Google Scholar
Read, J. (2008). Schizophrenia, drug companies and the internet. Social Science & Medicine 66, 99–109.CrossRefGoogle ScholarPubMed
Read, J. & Gumley, A. (2008). Can attachment theory help explain the relationship between childhood adversity and psychosis? Attachment 2, 1–35.Google Scholar
Read, J., Perry, B., Moskowitz, A. & Connolly, J. (2001). The contribution of early traumatic events to schizophrenia in some patients: a Traumagenic Neurodevelopmental model. Psychiatry: Interpersonal and Biological Processes 64, 319–345.Google Scholar
Read, J., Agar, K., Argyle, N. & Aderhold, V. (2003). Sexual and physical abuse during childhood and adulthood as predictors of hallucinations, delusions and thought disorder. Psychology and Psychotherapy: Theory, Research and Practice 76, 1–22.Google Scholar
Read, J., Goodman, L., Morrison, A., Ross, C. & Aderhold, V. (2004a). Childhood trauma, loss and stress. In Models of Madness (ed. Read, J., Mosher, L., Bentall, R.). Routledge: London.Google Scholar
Read, J., Seymour, F. & Mosher, L. (2004b). Unhappy families. In Models of Madness (ed. Read, J., Mosher, L., Bentall, R.). Routledge: London.Google Scholar
Read, J., Mosher, L. & Bentall, R. (Eds). (2004c). Models of Madness: Psychological, Social and Biological Approaches to Schizophrenia. Routledge: London.Google Scholar
Read, J., Haslam, N., Sayce, L. & Davies, E. (2006). Prejudice and schizophrenia: a review of the ‘mental illness is an illness like any other’ approach. Acta Psychiatrica Scandinavica 114, 303–318.Google Scholar
Read, J., van Os, J., Morrison, A. & Ross, C. (2005). Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatrica Scandinavica 112, 330–350.Google Scholar
Read, J., Mcgregor, K., Coggan, C. & Thomas, D. (2006). Mental health services and sexual abuse: The need for staff training. Journal of Trauma and Dissociation 7, 33–50.Google Scholar
Read, J., Hammersley, P. & Rudegeair, T. (2007). Why, when and how to ask about child abuse. Advances in Psychiatric Treatment 13, 101–110.Google Scholar
Read, J., Fink, P., Rudegeair, T., Felitti, V. & Whitfield, C. (2008). Child maltreatment and psychosis: A return to a genuinely integrated bio-psycho-social model. Clinical Schizophrenia and Related Psychoses 7, 235–254.Google Scholar
Ross, C. & Read, J. (2004). Antipsychotic medication: myths and facts. In Models of Madness: Psychological, Social and Biological Approaches to Schizophrenia (ed. Read, J., Mosher, L., Bentall, R.). Routledge: London.Google Scholar
Ruggeri, M. & Tansella, M. (2009). The interaction between genetics and epidemiology: the puzzle and its pieces. Epidemiologia e Psichiatria Sociale 18, 77–80.Google Scholar
Sanders, A., Duan, J., Levinson, D., Shi, J., He, D., Hou, C., Burrell, G., Rice, J., Nertney, D., Olincy, A., Rozic, P., Vinogradov, S., Buccola, N., Mowry, B., Freedman, R., Amin, F., Black, D., Silverman, J., Byerley, W., Crowe, R., Cloninger, C., Martinez, M. & Gejman, P. (2008). No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. American Journal of Psychiatry 165, 497–506.Google Scholar
Schreier, A., Wolke, D., Thomas, K., Horwood, J., Hollis, C., Gunnell, D., Lewis, G., Thompson, A., Zammit, S., Duffy, L., Salvi, G. & Harrison, G. (2009). Prospective study of peer victimization in childhood and psychotic symptoms in a nonclinical population at age 12 years. Archives of General Psychiatry 66, 527–536.Google Scholar
Scott, J., Chant, D., Andrews, G., Martin, G. & McGrath, J. (2007). Association between trauma exposure and delusion experiences in a large community-based sample. British Journal of Psychiatry 190, 339–343.Google Scholar
Selten, J-P., Veen, N., Feller, W., Blom, J., Schols, D., Camoenie, W., Oolders, J., van der Velden, M., Hoek, H., Rivero, V., van der Graaf, Y. & Kahn, R. (2001). Incidence of psychotic disorders in immigrant groups to The Netherlands. British Journal of Psychiatry 178, 367–372.Google Scholar
Sharfstein, S. (2005). Big Pharma and American psychiatry: the good, the bad and the ugly. Psychiatric News 40, 3.Google Scholar
Shenton, M., Dickey, C., Frumin, M. & McCarley, R. (2001). A review of MRI findings in schizophrenia. Schizophrenia Research 49, 1–52.Google Scholar
Shevlin, M., Dorahy, M. & Adamson, G. (2007). Childhood traumas and hallucinations: an analysis of the National Comorbidity Survey. Journal of Psychiatric Research 41, 222–228.Google Scholar
Shevlin, M., Murphy, J., Houston, J. & Adamson, G. (2009a). Childhood sexual abuse, early cannabis use, and psychosis: Testing the effects of different temporal orderings based on the National Comorbidity Survey. Psychosis: Psychological, Social and Integrative Approaches 1, 19–28.Google Scholar
Shevlin, M., Murphy, J., Houston, J. & Adams, G. (2009b). Childhood sexual abuse, early cannabis use and psychosis: Testing the effects of different temporal orderings based on the National Comorbidity Survey. Psychosis: Psychological, Social and Integrative Approaches 1, 19–28.Google Scholar
Shooter, M. (2005). Dancing with the devil? A personal view of psychiatry's relationship with the pharmaceutical industry. Psychiatric Bulletin 29, 81–83.Google Scholar
Smeets, T., Sjistermans, K., Gijsen, C., Peters, M., Jelicic, M. & Merckelbach, H. (2008). Acute consolidation stress enhances reality monitoring in healthy young adults. Stress 11, 235–245.Google Scholar
Spataro, J., Mullen, P., Burgess, P., Wekks, D. & Moss, S. (2004). Impact of child sexual abuse on mental heatlh: prospective study in males and females. British Journal of Psychiatry 184, 416–421.Google Scholar
Spauwen, J., Krannebdam, L., Lieb, R., Wittchen, H. & van Os, J. (2006). Impact of psychological trauma on the development of psychotic symptoms: Relationship with psychosis proneness. British Journal of Psychiatry 188, 527–533.Google Scholar
Thewissen, V., Myin-Germeys, I., Bentall, R., de Graaf, R., Vollenberg, W. & van Os, J. (2007). Instability in self-esteem and paranoia in a general population sample. Social Psychiatry and Psychiatric Epidemiology 42, 1–5.Google Scholar
Thewissen, V., Bentall, R., Lecomte, T., van Os, J. & Myin-Germeys, I. (2008). Fluctuations in self-esteem and paranoia in the context of everyday life. Journal of Abnormal Psychology 117, 143–153.Google Scholar
Tosato, S. & Lasalvia, A. (2009). The contribution of epidemiology to defining the most appropriate approach to genetic research on schizophrenia. Epidemiologia e Psichiatria Sociale 18, 81–90.CrossRefGoogle ScholarPubMed
Verdoux, H. & Tournier, M. (2004). Cannabis use and risk of psychosis: An etiological link? Epidemiologia e Psichiatria Sociale 13, 113–119.Google Scholar
Webster, M., Knable, M., O'Grady, J., Orthmann, J. & Weickert, C. (2002). Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Molecular Psychiatry 7, 985–94Google Scholar
Weinman, S., Read, J. & Aderhold, V. (2009). The influence of antipsy-chotics on mortality in schizophrenia: A systematic review. Schizophrenia Research 113, 1–11.Google Scholar
Welham, J., Isohanni, M., Jones, P. & McGrath, J. (2009). The antecedents of schizophrenia: a review of birth cohort studies. Schizophrenia Bulletin 35, 603–623.CrossRefGoogle ScholarPubMed
Whitfield, C., Dube, S., Felitti, V. & Andra, R. (2005). Adverse childhood experiences and hallucinations. Child Abuse & Neglect 29, 797–810.Google Scholar
Zubin, J. & Spring, B. (1977). Vulnerability – a new view of schizophrenia. Journal of Abnormal Psychology 86, 103–126.Google Scholar