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A simple approach to manage dosages in drug-epidemiology research

Published online by Cambridge University Press:  11 April 2011

Michela Nosè*
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
Corrado Barbui
Affiliation:
Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
*
Dr. M. Nosè, Department of Medicine and Public Health, Section of Psychiatry and Clinical Psychology, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona (Italy). Fax: +39-045-585871 E-mail: [email protected]

Extract

In the study of the beneficial and adverse effects of psychotropic drugs, in addition to experimental studies (Barbui et al., 2007), epidemiological studies may provide interesting insights. A key methodological aspect in drug utilization studies is how drug consumption should be measured. Specifically, the need is to end up with a single variable that may be reliably used to indicate the overall consumption, for each patient included in a certain survey, of one specific drug (for example one antipsychotic, say haloperidol) or a specific drug class (for example second-generation antipsychotics) or a group of drugs (for example psychotropic drugs, including antipsychotics plus antidepressants plus benzodiazepines). Not only such a variable has to accommodate the problem that actual doses cannot be directly compared, but also that many patients often receive more than one drug, belonging to different or to the same pharmacological class. A methodology is therefore needed to convert each medication dosage into a standardised measure that allows to calculate, for each patient, a cumulative index of drug consumption. Standardised measures of drug consumption are also beneficial for national and international comparisons, for the evaluation of time trends in drug use, and for assessing the public health impact of specific events (for example a change in reimbursement status).

Type
ABC of Methodology
Copyright
Copyright © Cambridge University Press 1988

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References

Barbui, C., Veronese, A. & Cipriani, A. (2007). Explanatory and pragmatic trias. Epidemiologia e Psichiatria Sociale 16, 124125.CrossRefGoogle Scholar
WHO Collaborating Centre for Drug Statistic Methodology (2003). Guidelines for ATC Classification and DDD Assignment. WHO Collaborating Centre for Drug Statistic Methodology: Oslo.Google Scholar