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Exposure to parental psychopathology and offspring's risk of suicide-related thoughts and behaviours: a systematic review

Published online by Cambridge University Press:  27 July 2017

S. M. Goodday ,
J. Shuldiner ,
S. Bondy  and
A. E. Rhodes
S. M. Goodday*
Affiliation:
Department of Epidemiology, University of Toronto, Dalla Lana School of Public Health, Toronto, Ontario, Canada
J. Shuldiner
Affiliation:
Department of Epidemiology, University of Toronto, Dalla Lana School of Public Health, Toronto, Ontario, Canada
S. Bondy
Affiliation:
Department of Epidemiology, University of Toronto, Dalla Lana School of Public Health, Toronto, Ontario, Canada
A. E. Rhodes
Affiliation:
Department of Epidemiology, University of Toronto, Dalla Lana School of Public Health, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Dalla Lana School of Public Health, Toronto, Ontario, Canada McMaster University, The Offord Centre for Child Studies, Hamilton, Ontario, Canada
*
*Address for correspondence: S. Goodday, Ph.D. candidate, Department of Epidemiology, University of Toronto, Dalla Lana School of Public Health, Toronto, Ontario, Canada. (Email: [email protected])
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Abstract

Aims.

The primary objective of this systematic review was to identify and synthesise analytic studies examining the association between exposure to parental psychopathology in childhood and the nature of subsequent suicide-related thoughts (SRT) and suicide-related behaviour (SRB) (severity of ideation, planned/unplanned attempts/lethality) and to describe the direction, and magnitude of associations. The secondary objective was to determine if the associations from the primary objective differ by the type(s) and timing of parental psychopathology, sex/gender of the parent and child and is mediated by child psychiatric symptoms and family functioning.

Methods.

A systematic review was conducted using guidelines from the PRISMA statement. MEDLINE, CINAHL, EMBASE, psycINFO, Web of Science and grey literature sources were searched by two reviewers to March, 2017. Studies were included if they examined any parental psychopathology (Diagnostic and Statistical Manual of Mental Disorders criteria or equivalent) or SRT or SRB and offspring SRT or SRB occurring from birth <25 years of age.

Results.

Out of 10 231 studies identified, 54 were included for review. Studies were clinically and methodologically heterogeneous with none at low risk of bias (ROB). Nine studies with moderate ROB indicated a significantly increased risk of offspring SRT, suicide attempts (SA) and suicide among those exposed to maternal SA and suicide in childhood or adolescence. In the remaining 45 studies with higher ROB this association persisted. Several studies (67%) did not confirm that the exposure occurred in the offspring's childhood or adolescence. Findings were suggestive of a mediating effect of offspring psychiatric symptoms, however, few studies examined mediation and effect modification of contextual variables.

Conclusions.

Offspring exposed to maternal SA are at an increased risk of these same behaviours early in life. Prospective attention to the types and timing of maternal and paternal psychopathology and the intermediate pathways to offspring SRT and SRB onset is needed and could have implications for informing modifiable targets for early intervention and prevention.

Keywords

Adolescencegender differencesmental healthsuicidesystematic reviews
Type
Original Articles
Information
Epidemiology and Psychiatric Sciences , Volume 28 , Issue 2 , April 2019 , pp. 179 - 190
Copyright
Copyright © Cambridge University Press 2017 

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References

Agerbo, E, Nordentoft, M, Mortensen, PB (2002). Familial, psychiatric, and socioeconomic risk factors for suicide in young people: nested case-control study. British Medical Journal 325, 74.Google Scholar
Brent, DA, Mann, JJ (2005). Family genetic studies, suicide, and suicidal behavior. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 133C, 13–24.Google Scholar
Brent, DA, Melhem, NM, Oquendo, M, Burke, A, Birmaher, B, Stanley, B, Biernesser, C, Keilp, J, Kolko, D, Ellis, S, Porta, G, Zelazny, J, Iyengar, S, Mann, J (2015). Familial pathways to early-onset suicide attempt: a 5.6-year prospective study. Journal of the American Medical Association Psychiatry 72, 160–168.Google Scholar
Bridge, JA, Goldstein, TR, Brent, DA (2006). Adolescent suicide and suicidal behavior. Journal of Child Psychology and Psychiatry 47, 372–394.Google Scholar
Cavanagh, JT, Carson, AJ, Sharpe, M, Lawrie, SM (2003). Psychological autopsy studies of suicide: a systematic review. Psychological Medicine 33, 395–405.Google Scholar
Cheng, CC, Yen, WJ, Chang, WT, Wu, KC, Ko, MC, Li, CY (2014). Risk of adolescent offspring's completed suicide increases with prior history of their same-sex parents’ death by suicide. Psychological Medicine 44, 1845–1854.Google Scholar
Christiansen, E, Larsen, KJ (2012). Young people's risk of suicide attempts after contact with a psychiatric department – a nested case-control design using Danish register data. Journal of Child Psychology and Psychiatry 53, 16–25.Google Scholar
Cox, LJ, Stanley, BH, Melhem, NM, Oquendo, MA, Birmaher, B, Burke, A, Kolko, DJ, Zelazny, JM, Mann, JJ, Porta, G, Brent, DA (2012). Familial and individual correlates of nonsuicidal self-injury in the offspring of mood-disordered parents. Journal of Clinical Psychiatry 73, 813–820.Google Scholar
Evans, E, Hawton, K, Rodham, K (2004). Factors associated with suicidal phenomena in adolescents: a systematic review of population-based studies. Clinical Psychological Review 24, 957–979.Google Scholar
Fergusson, DM, Woodward, LJ, Horwood, LJ (2000). Risk factors and life processes associated with the onset of suicidal behaviour during adolescence and early adulthood. Psychological Medicine 30, 23–39.Google Scholar
Fotti, SA, Katz, LY, Afifi, TO, Cox, BJ (2006). The associations between peer and parental relationships and suicidal behaviours in early adolescents. Canadian Journal of Psychiatry 51, 698–703.Google Scholar
Friedman, RC, Corn, R, Hurt, SW, Fibel, B, Schulick, J, Swirsky, S (1984). Family history of illness in the seriously suicidal adolescent – A life cycle approach. American Journal of Orthopsychiatry 54, 390–397.Google Scholar
Garber, J, Little, S, Hilsman, R, Weaver, KR (1998). Family predictors of suicidal symptoms in young adolescents. Journal of Adolescence 21, 445–457.Google Scholar
Geoffroy, MC, Gunnell, D, Power, C (2014). Prenatal and childhood antecedents of suicide: 50-year follow-up of the 1958 British Birth Cohort study. Psychological Medicine 44, 1245–1256.Google Scholar
Geulayov, G, Gunnell, D, Holmen, TL, Metcalfe, C (2012 a). The association of parental fatal and non-fatal suicidal behaviour with offspring suicidal behaviour and depression: a systematic review and meta-analysis. Psychological Medicine 42, 1567–1580.Google Scholar
Geulayov, G, Metcalfe, C, Gunnell, DJ (2012 b). Parental suicide attempt and offspring self-harm and suicidal thoughts: results from the alspac birth cohort. Journal of Epidemiological Community Health 66, A25–A25.Google Scholar
Glowinski, AL, Heath, AC (2001). Parental alcohol dependence and suicidal behavior in adolescent female twins. Behavior Genetics 31, 454–454.Google Scholar
Gureje, O, Oladeji, B, Hwang, I, Chiu, WT, Kessler, RC, Sampson, NA, Alonso, J, Andrade, LH, Beautrais, A, Borges, G, Bromet, E, Bruffaerts, R, de Girolamo, G, de Graaf, R, Gal, G, He, Y, Hu, C, Iwata, N, Karam, EG, Kovess-Masféty, V, Matschinger, H, Moldovan, MV, Posada-Villa, J, Sagar, R, Scocco, P, Seedat, S, Tomov, T, Nock, MK (2011). Parental psychopathology and the risk of suicidal behavior in their offspring: results from the World Mental Health surveys. Molecular Psychiatry 16, 1221–1233.Google Scholar
Hammerton, G, Zammit, S, Mahedy, L, Pearson, RM, Sellers, R, Thapar, A, Collishaw, S (2015). Pathways to suicide-related behavior in offspring of mothers with depression: the role of offspring psychopathology. Journal of the American Academy of Child Adolescent Psychiatry 54, 385–393.Google Scholar
Hammerton, G, Zammit, S, Thapar, A, Collishaw, S (2016). Explaining risk for suicidal ideation in adolescent offspring of mothers with depression. Psychological Medicine 46, 265–275.Google Scholar
Hawley, DR, DeHaan, L (1996). Toward a definition of family resilience: integrating life-span and family perspectives. Family Process 35, 283–298.Google Scholar
Hawton, K, Harriss, L (2007). Deliberate self-harm in young people: characteristics and subsequent mortality in a 20-year cohort of patients presenting to hospital. Journal of Clinical Psychiatry 68, 1574–1583.Google Scholar
Isohookana, R, Riala, K, Hakko, H, Rasanen, P (2013). Adverse childhood experiences and suicidal behavior of adolescent psychiatric inpatients. European Child Adolescent Psychiatry 22, 13–22.Google Scholar
Jakobsen, IS, Christiansen, E (2011). Young people's risk of suicide attempts in relation to parental death: a population-based register study. Journal of Child Psychology and Psychiatry 52, 176–183.Google Scholar
Kerr, DC, Owen, LD, Capaldi, DM (2008). Suicidal ideation and its recurrence in boys and men from early adolescence to early adulthood: an event history analysis. Journal of Abnormal Psychology 117, 625–636.Google Scholar
King, CA, Kerr, DC, Passarelli, MN, Foster, CE, Merchant, CR (2010). One-year follow-up of suicidal adolescents: parental history of mental health problems and time to post-hospitalization attempt. Journal of Youth Adolescence 39, 219–232.Google Scholar
Klimes-Dougan, B, Free, K, Ronsaville, D, Stilwell, J, Welsh, CJ, Radke-Yarrow, M (1999). Suicidal ideation and attempts: a longitudinal investigation of children of depressed and well mothers. Journal of the American Academy of Child and Adolescent Psychiatry 38, 651–659.Google Scholar
Klimes-Dougan, B, Lee, CY, Ronsaville, D, Martinez, P (2008). Suicidal risk in young adult offspring of mothers with bipolar or major depressive disorder: a longitudinal family risk study. Journal of Clinical Psychology 64, 531–540.Google Scholar
Kuramoto, SJ, Stuart, EA, Runeson, B, Lichtenstein, P, Långström, N, Wilcox, HC (2010). Maternal or paternal suicide and offspring's psychiatric and suicide-attempt hospitalization risk. Pediatrics 126, e1026–e1032.Google Scholar
Lewinsohn, PM, Olino, TM, Klein, DN (2005). Psychosocial impairment in offspring of depressed parents. Psychological Medicine 35, 1493–1503.Google Scholar
Lieb, R, Bronisch, T, Höfler, M, Schreier, A, Wittchen, H-U (2005). Maternal suicidality and risk of suicidality in offspring: findings from a community study. American Journal of Psychiatry 162, 1665–1671.Google Scholar
Ljung, T, Lichtenstein, P, Sandin, S, D'Onofrio, B, Runeson, B, Långström, N, Larsson, H (2013). Parental schizophrenia and increased offspring suicide risk: exploring the causal hypothesis using cousin comparisons. Psychological Medicine 43, 581–590.Google Scholar
Mittendorfer-Rutz, E, Rasmussen, F, Wasserman, D (2008). Familial clustering of suicidal behaviour and psychopathology in young suicide attempters. Social Psychiatry and Psychiatric Epidemiology 43, 28–36.Google Scholar
Moher, D, Liberati, A, Tetzlaff, J, Altman, DG, Group, P (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. British Medical Journal 339, b2535.Google Scholar
Niederkrotenthaler, T, Floderus, B, Alexanderson, K, Rasmussen, F, Mittendorfer-Rutz, E (2012). Exposure to parental mortality and markers of morbidity, and the risks of attempted and completed suicide in offspring: an analysis of sensitive life periods. Journal of Epidemiology and Community Health 66, 233–239.Google Scholar
Peter, T, Roberts, LW, Buzdugan, R (2008). Suicidal ideation among Canadian youth: a multivariate analysis. Archives of Suicide Research 12, 263–275.Google Scholar
Reyes, JC, Robles, RR, Colón, HM, Negrón, JL, Matos, TD, Calderón, JM (2011). Polydrug use and attempted suicide among Hispanic adolescents in Puerto Rico. Archives of Suicide Research 15, 151–159.Google Scholar
Rhodes, A, Boyle, MH, Bridge, JA, Sinyor, M, Links, PS, Tonmyr, L, Skinner, R, Bethell, J, Carlisle, C, Goodday, S, Salway Hottes, T, Newton, A, Bennett, K, Sundar, P, Cheung, AH, Szatmari, P (2014). Antecedents and sex/gender differences in youth suicidal behavior. World Journal of Psychiatry 4, 120–132.Google Scholar
Rossow, I, Moan, I (2012). Parental intoxication and adolescent suicidal behavior. Archives of Suicide Research 16, 73–84.Google Scholar
Silverman, MM, Berman, AL, Sanddal, ND, O'Carroll, PW, Joiner, TE (2007). Rebuilding the tower of Babel: a revised nomenclature for the study of suicide and suicidal behaviors. Part 2: suicide-related ideations, communications, and behaviors. Suicide and Life Threatening Behavior 37, 264–277.Google Scholar
Soole, R, Kolves, K, De Leo, D (2014). Suicide in children: a systematic review. Archives of Suicide Research 19, 285–304.Google Scholar
Statham, DJ, Heath, AC, Madden, PA, Bucholz, KK, Bierut, L, Dinwiddie, SH, Slutske, WS, Dunne, MP, Martin, NG (1998). Suicidal behaviour: an epidemiological and genetic study. Psychological Medicine 28, 839–855.Google Scholar
Sterne, J, Higgins, P, Reeves, B (2014). On behalf of the development group for ACROBAT-NRSI. A cochrane risk of bias assessment tool: for non-randomized studies of interventions (ACROBAT-NRSI), version 1.0. 0, 24.Google Scholar
Tsypes, A, Gibb, BE (2015). Peer victimization mediates the impact of maternal depression on risk for suicidal ideation in girls but not boys: a prospective study. Journal of Abnormal Child Psychology 43, 1439–1445.Google Scholar
Wanner, B, Vitaro, F, Tremblay, RE, Turecki, G (2012). Childhood trajectories of anxiousness and disruptiveness explain the association between early-life adversity and attempted suicide. Psychological Medicine 42, 2373–2382.Google Scholar
Weissman, MM, John, K, Merikangas, KR, Prusoff, BA, Wickramaratne, P, Gammon, GD, Angold, A, Warner, V (1986). Depressed parents and their children. General health, social, and psychiatric problems. American Journal of Diseases of Children 140, 801–805.Google Scholar
World Health Organization (2014). Preventing Suicide. A Global Imperative, pp. 1–89. World Health Organization: Geneva, Switzerland.Google Scholar
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