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The economic perspective in the care and treatment of patients with diagnosis of schizophrenia

Published online by Cambridge University Press:  11 October 2011

Mauro Percudani*
Affiliation:
Unità Operativa di Psichiatria di Magenta, Ospedale Civile di Legnano, Legnano (Mi)
Martin Knapp
Affiliation:
London School of Economics and Institute of Psychiatry, London, UK
*
Indirizzo per la corrispondea: Dr. Percudani Unità Operativa di Psichiatria - CPS, Via Fornaroh 67, 20013 Magenta (Milano) Fax: +39 - 02-9729.1354

Summary

Objective - To consider the main problems associated with care and treatment of patients with diagnosis of schizophrenia in the light of the more recent literature of the economic aspects of this pathology. Method - An analysis of the literature related to the social costs of schizophrenia, the economic analysis of different health-care models, and the evaluation of the costs of antipsychotic treatments has been carried out. Results - Schizophrenia is a pathology creating huge social costs. The health costs associated with the care of schizophrenia take up a significant amount of the resources of healthcare systems in the principal industrialised countries. Indirect costs, due mainly to the patients' exclusion from work, exceed the direct costs of treatment. In those countries where community care has been supported by a real organisational effort to create community and residential services, it has proved to be a cost-effective solution compared with psychiatric hospital-based care and provides patients and family members with better results. The introduction of new antipsychotic drugs and the development of psychosocial support could represent the means of encouraging new healthcare strategies. Conclusions - From an economic perspective, the organisation, technological means, and strategies which would allow the available resources to be invested in a rational way must be considered. Consideration of these issues appears to be unavoidable today, not only for the administrators and the policy makers but also for mental health service professionals.

Riassunto

Scopo - Considerare le principali problematiche connesse all'assistenza ed al trattamento dei pazienti con diagnosi di schizofrenia alia luce della piu recente letteratura sugli aspetti economici di questa patologia. Metodo - È stata effettuata una analisi della letteratura relativa ai costi sociali della schizofrenia, all'analisi economica di diversi modelli di assistenza, alia valutazione dei costi dei trattamenti antipsicotici. Risultati - La schizofrenia è una patologia che genera ingenti costi sociali. I costi sanitari legati all'assistenza alia schizofrenia assorbono una percentuale significativa delle risorse dei sistemi sanitari dei principali paesi industrializzati. I costi indiretti, dovuti principalmente al mancato inserimento al lavoro dei pazienti, risultano superiori ai costi diretti di trattamento. Nei paesi ove l'assistenza centrata sul territorio è stata supportata da un reale sforzo organizzativo per la creazione di servizi territoriali e residenziali, è emerso che essa è meno costosa dell'assistenza centrata sull'ospedale psichiatrico e genera un miglior esito per pazienti e familiari. L'introduzione di nuovi farmaci antipsicotici e lo sviluppo di interventi di tipo psicosociale possono rappresentare strumenti che favoriscono nuove strategie di assistenza. Conclusion! - Utilizzare una prospettiva economica implica pensare a quale organizzazione, quali strumenti tecnologici, quali strategie permettono di investire con razionalita le risorse disponibili. Una riflessione su questi temi appare oggi ineludibile non solo per gli amministratori ed i decisori politici, ma anche per gli operatori dei servizi di salute mentale.

Type
Articles
Copyright
Copyright © Cambridge University Press 1998

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References

BIBLIOGRAFIA

Addington, D.E., Jones, B., Bloom, D., Chouinard, G., Remington, G. & Albright, P. (1993). Reduction of hospital days in chronic schizophrenic patients treated with risperidone: a retrospective study. Clinical Therapeutics 15(5), 917926.Google ScholarPubMed
Aitchison, K.J. & Kerwin, R.W. (1997). Cost-effectiveness of clozapine. British Journal of Psychiatry 171, 125130.CrossRefGoogle ScholarPubMed
Albright, P.S., Livingstone, S., Keegan, D., Ingham, M., Shrikhande, S. & Le Lorier, J. (1996). Reduction of healthcare resource utilisation and costs following the use of risperidone for patients with schizophrenia previously treated with standard antipsychotic therapy. A retrospective analysis using the Saskatchewan health linkable databases. Clinical Drug Investigation 5, 289299.CrossRefGoogle Scholar
Altamura, A.C. (1992). A multidimensional (pharmacokinetic and clinical-biological) approach to neuroleptic response in schizophrenia. Schizophrenia Research 8, 187198.CrossRefGoogle Scholar
Amaddeo, F., Bonizzato, P. & Tansella, M. (1997a). Psychiatric case registers for monitoring sevice utilisation and evaluating its costs. In: Making Rational Mental Health Services (ed. Tansella, M.). Epidemiologia e Psichiatria Sociale, Monograph Supplement No. 1, pp. 177198. II Pensiero Scientifico Editore: Roma.Google Scholar
Amaddeo, F., Beecham, J., Bonizzato, P., Fenyo, A., Tansella, M. & Knapp, M. (1997b). The use of a case register to evaluate the costs of psychiatric care. Ada Psychiatrica Scandinavica 95, 195198.CrossRefGoogle ScholarPubMed
Amaddeo, F., Bonizzato, P. & Tansella, M. (1997c). Valutare i Costi in Psichiatria. L'Analisi Economica per Migliorare VAssistenza. Il Pensiero Scientifico Editore: Roma.Google Scholar
Amaddeo, F., Beecham, J., Bonizzato, P., Fenyo, A., Tansella, M. & Knapp, M. (1998). The costs of community-based psychiatric care for first-ever patients. A case register study. Psychological Medicine 28, 173183.Google ScholarPubMed
Andrews, G., Goldstein, G., Hall, W., Lapsley, H., Bartels, R. & Silove, D. (1985). The economic costs of schizophrenia. Archives of General Psychiatry 42, 537543.CrossRefGoogle ScholarPubMed
Balestrieri, M., Micciolo, R., De Salvia, D. & Tansella, M. (1992). Confronti e prospettive nella utilizzazione dei Registri Psichiatrici dei Casi. Epidemiologia e Psichiatria Sociale 1(2), 133148.CrossRefGoogle Scholar
Barnes, T.R.E. (1992). Clinical assessment of the extrapyramidal side effects of antipsychotic drugs. Journal of Psychopharmacology 6, 214221.CrossRefGoogle ScholarPubMed
Bindman, J., Davies, S., Taylor, R. & Thornicroft, G. (1996). Developments in mental health policy in the United Kingdom. Epidemiologia e Psichiatria Sociale 5(2), 8791.CrossRefGoogle Scholar
Bond, G. R. (1984). An economic analysis of psychosocial rehabilitation. Hospital and Community Psychiatry 35, 356362.Google ScholarPubMed
Brenner, H.D., Roder, V., Hodel, B., Kienzle, N., Reed, D. & Liberman, R.P. (1994). Integrated Psychological Therapy for Schizophrenic Patients. Hogrefe & Huber Publishers: Seattle. (Trad. it. a cura di A. Vita e G. Invernizzi, Terapia psicologica integrata., 1997, McGraw-Hill Libri Italia: Milano).Google Scholar
Brown, S. (1997). Excess mortality of schizophrenia. A meta-analysis. British Journal of Psychiatry 171, 502508.CrossRefGoogle ScholarPubMed
Burns, T., Beadsmoore, A., Bhat, A.V., Oliver, A. & Mathers, C. (1993a). A controlled trial of home-based acute psychiatric services. 1: Clinical and social outcome. British Journal of Psychiatry 163, 4954.CrossRefGoogle Scholar
Burns, T., Raftery, J., Beadsmoore, A., McGuigan, S. & Dickson, M. (1993b). A controlled trial of home-based acute psychiatric services. 2: Treatment pattern and costs. British Journal of Psychiatry 163, 4954.CrossRefGoogle Scholar
Caldas de Almeida, J.M. (1996). Community psychiatry in Portugal. Epidemiologia e Psichiatria Sociale 5(2), 9295.CrossRefGoogle Scholar
Chouinard, G. & Albright, P.S. (1997). Economic and health state utility determinations for schizophrenic patients treated with risperidone and haloperidol. Journal of Clinical Psychopharmacology 17 (4), 298307.CrossRefGoogle ScholarPubMed
Chouinard, G., Jones, B., Remington, G., Bloom, D., Addington, D., MacEwan, G.W., Labelle, A., Beaudair, L. & Arnott, W. (1993). A Canadian munticenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients. Journal of Clinical Psychopharmacology 13, 2540.CrossRefGoogle ScholarPubMed
Cocchi, A. & De Isabella, G. (ed.) (1993). Centri Diurni in Psichiatria. Franco Angeli: Milano.Google Scholar
Connolly, J., Marks, I., Lawrence, R., McNamee, G. & Muijen, M. (1996). Observations from community care for serious mental illness during a controlled study. Psychiatric Bulletin 20, 37.CrossRefGoogle Scholar
Davies, L.M. & Drummond, M.F. (1990). The economic burden of schizophrenia. Psychiatric Bulletin 14, 522525.CrossRefGoogle Scholar
Davies, L.M. & Drummond, M.F. (1994). Economics and schizophrenia: the real cost. British Journal of Psychiatry 165, Suppl. 25, 1821.CrossRefGoogle Scholar
Davis, J.M., Barter, J. & Kane, J.M. (1989). Antipsychotic drugs. In Comprehensive Textbook of Psychiatry, 5th ed. (ed. Kaplan, H.I. and Saddock, B.J.), pp. 15911626. Williams and Wilkins: Baltimore.Google Scholar
Dean, C., Phillips, J., Gadd, E.M., Joseph, M. & England, S. (1993). Comparison of community based service with hospital based service for people with acute severe psychiatric illness. British Medical Journal 307, 473476.CrossRefGoogle ScholarPubMed
Deci, A., Santos, A.B., Hiott, W., Schoenwald, S. & Dias, J.K.(1995). Dissemination of assertive community treatment programs. Psychiatric Services 46, 676678.Google ScholarPubMed
de Jesus Mari, J. & Streiner, D.L. (1994). An overview of family interventions and relapse on schizophrenia: a meta-analysis of research findings. Psychological Medicine 24, 565578.CrossRefGoogle Scholar
De Salvia, D. & Barbato, A. (1993). Recent trends in mental health services in Italy: an analysis of national and local data. Canadian Journal of Psychiatry 38, 195202.CrossRefGoogle ScholarPubMed
Drummond, M.F. (1980). Economic Appraisal in Health Care. Oxford University Press: Oxford.Google Scholar
Drummond, M.F., O'Brien, B., Stoddart, G.L. & Torrance, G.W. (1997). Methods for the Economic Evaluation of Health Care Programmes, 2nd ed.Oxford University Press: Oxford.Google Scholar
Erlicher, A. (1997). II monitoraggio del processo di superamento dell'ospedale psichiatrico. Comunicazione personale al 3 Congresso Nazionale della Societa Italiana di Epidemiologia Psichiatrica, Milano 19-21 novembre 1997.Google Scholar
Evers, S. & Ament, A. (1995). Cost of schizophrenia in The Netherlands. Schizophrenia Bullettin 21(1), 141153.CrossRefGoogle ScholarPubMed
Foster, K., Meltzer, H., Gill, B. & Hinds, K. (1996). Adults with a Psychotic Disorder Living in the Community. OPCS Surveys of Psychiatric Morbidity Report 8. HMSO: London.Google Scholar
Geronimi-Ferret, D., Lesay, M., Barges-Bertocchio, M.N., Cornet-Bonnefont, M. & Robert, H. (1997). Evaluation medico-economique du traitement par la clozapine versus les traitements neurolipliques anterieurs. L'Encephale, Suppl. 4, 2431.Google Scholar
Gerzeli, S., Marinoni, A., Demicheli, V., Carolei, A., Baconcini, C. & Gruppo di Ricerca PSIL. (1997). Valutazionc dei costi delle cure di pazienti schizofrenici: 5 anni di follow-up di pazienti schizofrenici utenti dei servizi psichiatrici liguri. Sistema Salute 1, 17.Google Scholar
Gilbert, P.L., Harris, M.J., McAdams, L.A. & Jeste, D.V. (1995). Neuroleptic withdrawal in schizophrenic patients: a review of the literature. Archives of General Psychiatry 52, 173188.CrossRefGoogle ScholarPubMed
Gunderson, J.G. & Mosher, L.R. (1975). The cost of schizophrenia. American Journal of Psychiatry 132, 901910.Google ScholarPubMed
Honigfeld, G. & Patin, J. (1990). A two-year clinical and economic follow-up of patients on clozapine. Hospital and Community Psychiatry 41 (8), 882885.Google ScholarPubMed
Hoult, J. & Reynolds, I. (1984). Schizophrenia: a comparative trial of community oriented and hospital oriented psychiatric care. Ada Psychiatrica Scandinavica 69, 359372.CrossRefGoogle ScholarPubMed
Istituto Italiano di Medicina Sociale (1996). L'assistenza Psichiatrica in Italia: la Normativa e la Diffusione dei Servizi sul Territorio (a cura di M. Cozza, M. e Napolitano, G.M.). Istituto Italiano di Medicina Sociale Editore: Roma.Google Scholar
Jablensky, A. (1986). Epidemiology of schizophrenia: a European perspective. Schizophrenia Bulletin, 12: 5273.CrossRefGoogle ScholarPubMed
Johnstone, E.C., Crow, T.J., Fifth, C.D., Carney, M.W. & Price, J.S. (1978). Mechanism of the antipsychotic effect in the treatment of acute schizophrenia. Lancet 1, 848851.CrossRefGoogle ScholarPubMed
Jonsson, D. & Walinder, J. (1995) Cost-effectiveness of clozapine treatment in therapy-refrectory schizophrenia. Ada Psychiatrica Scandinavica 92, 199201.CrossRefGoogle ScholarPubMed
Kane, J.M., Honigfeld, G., Singer, J., Meltzer, H. & the Clozaril Collaborative Group. (1988). Clozapine for the treatment-resistant schizophrenic. Archives of General Psychiatry 45, 789796.CrossRefGoogle ScholarPubMed
Kavanagh, S., Opit, L., Knapp, M. & Beecham, J. (1995). Schizophrenia: shifting the balance of care. Social Psychiatry and Psychiatric Epidemiology 30, 206212.CrossRefGoogle ScholarPubMed
Knapp, M. (1997). Costs of schizophrenia. British Journal of Psychiatry 171, 509518.CrossRefGoogle ScholarPubMed
Knapp, M. & Kavanagh, S. (1997). Economic outcomes and costs in the treatment of schizophrenia. Clinical Therapeutics 19 (1), 128138.CrossRefGoogle ScholarPubMed
Knapp, M.R.J., Beecham, J.K., Koutsogeorgopoulou, V., Hallam, A., Fenyo, A.J., Marks, I., Connolly, J., Audini, B. & Muijen, M. (1994). Service use and costs of home-based versus hospital-based care for people with serious mental illness. British Journal of Psychiatry 165, 195203.CrossRefGoogle ScholarPubMed
Knapp, M., Chisholm, D., Astin, J., Lelliott, P. & Audini, B. (1997). The cost consequences of changing the hospital-community balance: the mental health residential care study. Psychological Medicine 27, 681692.CrossRefGoogle ScholarPubMed
Knapp, M.R.J., Marks, I.M., Wolstenholme, J., Beecham, J., Astin, J., Audini, B., Connolly, J. & Watts, V. (1998). Home-based versus hospital-based care for serious mental illness: a controlled cost-effectiveness study over four years. British Journal of Psychiatry 172, 506512.CrossRefGoogle ScholarPubMed
Kuipers, L. (1993). Family burden in schizophrenia: implications for services. Social Psychiatry and Psychiatric Epidemiology 28, 207210.CrossRefGoogle ScholarPubMed
Lam, D.H. (1991). Psychosocial family intervention in schizophrenia: a review of empirical studies. Psychological Medicine 21, 423441.CrossRefGoogle ScholarPubMed
Lamb, H.R. (1993). Lessons learned from deistitutionalisation in the US. British Journal of Psychiatry 162, 587592.CrossRefGoogle ScholarPubMed
Leff, J., Trieman, N. & Gooch, C. (1996). Prospective follow-up study of long-stay patients discharged from two psychiatric hospitals. American Journal of Psychiatry 153, 13181324.Google ScholarPubMed
Liberman, R.P. (1987). Psychiatric Rehabilitation of Chronic Mental Patients. American Psychiatric Press: Washington.Google Scholar
Liberman, R.P. (ed.) (1992). Handbook of Psychiatric Rehabilitation. (Trad. it. a cura di M. Bassi, La riabilitazione psichiatrica, 1997, Raffaello Cortina Editore: Milano).Google Scholar
Malamud, T.J. & McCrory, D.J. (1988). Transitional employment and psychosocial rehabilitation. In Vocational Rehabilitation of Person with Prolonged Mental Illness (ed. Ciardello, J.A. and Bell, M.D.), pp 150162. John Hopkins Press: Baltimore.Google Scholar
Marks, I.M., Connolly, J., Muijen, M., MacNamee, G., Audini, B. & Lawrence, R.E. (1994). Home-based versus hospital-based care for people with serious mental illness. British Journal of Psychiatry 165, 179194.CrossRefGoogle ScholarPubMed
Me Guire, T.G. (1991). Measuring the economic costs of schizophrenia. Schizophrenia Bulletin 17(3), 375387.CrossRefGoogle Scholar
Meltzer, H.Y. (1995). Atypical antipsychotic drugs. In Psychopharmacology: the Fourth Generation of Progress (ed. Bloom, F.E. and Kupfer, D.J.), pp 12771286. Raven Press: New York.Google Scholar
Meltzer, H.Y., Cola, P., Way, L., Thompson, P.A., Bastani, B., Davies, M.A. & Snitz, B. (1993). Cost effectiveness of clozapine in neuroleptic resistant-schizophrenia. American Journal of Psychiatry 150, 16301638.Google ScholarPubMed
Montanelli, R. & Tarricone, R. (1997). Il costo sociale della schizofrenia. Unarassegnaragionatadellabibliografia. Mecosan, 21 2131.Google Scholar
Moscarelli, M., Capri, S. & Neri, L. (1991). Cost evaluation of chronic schizophrenic patients during the first 3 years after first contact. Schizophrenia Bulletin 17, 421426.CrossRefGoogle ScholarPubMed
Muijen, M. & Hadley, T. (1995). Community care: parts and systems. In Schizophrenia (ed. Hirsch, S.R. and Weinberger, D.R.), pp 649663. Blackwell Science: Oxford.Google Scholar
Muijen, M., Marks, I.M., Connolly, J., Audini, B. & McNamee, G. (1992). The daily living programme: preliminary comparison of community versus hospital-based treatment for the seriously mentally ill facing emergency admission. British Journal of Psychiatry 160, 379384.CrossRefGoogle ScholarPubMed
Muller, C.F. & Caton, C.L.M. (1983). Economic costs of schizophrenia. A postdischarge survey. Medical Care 21, 92104.CrossRefGoogle Scholar
Muscettola, G., Pampallona, S., Barbato, G., Casiello, M. & Bollini, P. (1989). Epidemiology and risk factors for tardive dyskinesia. Archives of General Psychiatry 46, 754755.Google Scholar
Penn, D. & Mue'ser, K.T. (1996) Research update on the psychosocial treatment of schizophrenia. American Journal of Psychiatry 153, 607617.Google ScholarPubMed
Percudani, M., Fattore, G., Galletta, J., Mita, P.L., Contini, A. & Altamura, A.C. (1998). Health care costs of therapy-refractory schizophrenic patients treated with clozapine: a study in a Community Psychiatric Service in Italy. Ada Psychiatrica Scandinavica (in press).Google Scholar
Peuskens, J. & Link, C.G.G. (1997). A comparison of quatiapine and chlorpromazine in the treatment of schizophrenia. Ada Psychiatrica Scandinavica 96. 265273.CrossRefGoogle ScholarPubMed
Reker, T. & Eikelmann, B. (1997). Work therapy for schizophrenic patients: results of a 3-year prospective study in Germany. European Archives of Psychiatry and Clinical Neurosciences 247, 414–319.CrossRefGoogle ScholarPubMed
Reid, W.H., Mason, M. & Toprac, M. (1994). Savings in hospital bed-days related to treatment with clozapine. Hospital and Community Psychiatry 45, 261264.Google ScholarPubMed
Revicki, D.A., Luce, B.R., Wechsler, J.M., Brown, R.E. & Adler, M.A. (1990). Cost-effectiveness of clozapine in treatment-resistant schizophrenic patients. Hospital and Community Psychiatry, 41, 850854.Google ScholarPubMed
Robert, G. & Kennedy, P. (1997). Establishing cost-effectiveness of atypical neuroleptics. British Journal of Psychiatry 171, 103104.CrossRefGoogle ScholarPubMed
Rosenheck, R., Cramer, J., Xu, W., Thomas, J., Henderson, W., Frisman, L., Fye, C. & Charney, D. (1997). A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. The New England Journal of Medicine, 337 (12), 809852.CrossRefGoogle ScholarPubMed
Rouillon, F., Dansette, G.Y. & Le Floch, C. (1994). Etude de la prise en charge therapeutique des schizophrenes et de son cout. L'Encephale 20, 303309.Google Scholar
Rubio, Stipec M., Stipec, B. & Canino, G. (1994). The costs of schizophrenia in Puerto Rico. The Journal of Mental Health Administration, 21(2), 136144.CrossRefGoogle Scholar
Rupp, A. & Keith, S.J. (1993). The costs of schizophrenia assessing the burden. Psychiatric Clinics of North America 16, 413423.CrossRefGoogle ScholarPubMed
Salize, H.J. & Rossler, W. (1996). The cost of comprehensive care of people with schizophrenia living in the community. A cost evaluation from a German catchment area. British Journal of Psychiatry 169, 4248.CrossRefGoogle ScholarPubMed
Saraceno, B. (1996). Psichiatria comunitaria in Italia. Epidemiologia e Psichiatria Sociale 5(2), 96102CrossRefGoogle Scholar
Scazufca, M. & Kuipers, E. (1996). Links between expressed emotion and burden of care in relatives of patients with schizophrenia. British Journal of Psychiatry 168 (5), 580587.CrossRefGoogle ScholarPubMed
Schene, A.H. (1996). Issue in Dutch community mental healt care. Epidemiologia e Psichiatria Sociale 5(2), 104106.CrossRefGoogle Scholar
Schneider, J. & Hallam, A. (1997). Specialist work schemes: user satisfaction and costs. Psychiatric Bulletin 21, 331333.CrossRefGoogle Scholar
Sharfstein, S.S. (1991). Prospective cost allocations for the chronic schizophrenic patient. Schizophrenia Bulletin 17(3), 395400.CrossRefGoogle ScholarPubMed
Stein, L.I. & Test, M.A. (1980). Alternative to mental hospital treatment. I. Conceptual model, treatment program and clinical evaluation. Archives of General Psychiatry 37, 392397.CrossRefGoogle ScholarPubMed
Suleiman, T.G., Ohaeri, J.U., Lawal, R.A., Haruna, A.Y. & Orija, O.B. (1997). Financial cost of treating out-patients with schizophrenia in Nigeria. British Journal of Psychiatry 171, 364368.CrossRefGoogle ScholarPubMed
Tarricone, R., Gerzeli, S. & Montanelli, R. (1997). Health care costs of schizophrenia. In Books of Abstracts International Conference on Health Economics. 15-17 October 1997, Evora, Portugal.Google Scholar
Tarrier, N., Lowson, K. & Barrowclough, C. (1991). Some aspects of family interventions in schizophrenia. II. Financial considerations. British Journal of Psychiatry 159, 481484.CrossRefGoogle ScholarPubMed
Test, M.A., Knoedler, W.H., Allness, D.J. et al. (1991). Long-term community care through an assertive continous team. Advance in Neuropsychiatry 1, 239246.Google Scholar
Tollefson, G.D., Beasley, C.M., Tran, V. P., Street, J.S., Krueger, J.A., Tamura, R.N., Graffeo, K.A. & Thieme, M.E. (1997). Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: results of an international collaborative trial. American Journal of Psychiatry 154 (4), 457465.Google ScholarPubMed
van Putten, T., May, P.R.A. & Marder, S.R. (1984a). Akathisia with haloperidol and thiothixene. Archives of General Psychiatry 41, 10361039.CrossRefGoogle ScholarPubMed
van Putten, T., May, P.R.A. & Marder, S.R. (1984b). Response to antipsychotic medication: the doctor's and the consumer's view. American Journal of Psychiatry 141, 1619.Google ScholarPubMed
Vaughan, C.E. & Leff, J.P. (1976). The influence of family and social factors on the course of psychiatric illness. A comparison of schizophrenic and depressed neurotic outpatients. British Journal of Psychiatry 129, 125137.CrossRefGoogle Scholar
Viale, G., Mechling, L., Maisling, G., Durkin, M., Engelhart, L. & Lawrence, B.J. (1997). Impact of risperidone on the use of mental health care resources. Psychiatric Services, 48(9), 11531159.Google ScholarPubMed
Watt, D.C., Katz, K. & Shepherd, M. (1983). The natural history of schizophrenia: a five-year prospective follow-up of a representative sample of schizophrenics by means of a standardized clinical and social assessment. Psychological Medicine 13, 663670.CrossRefGoogle Scholar
Weiden, P.J. & Olfson, M. (1995). Cost of relapse in schizophrenia. Schizophrenia Bulletin 21(3), 419429.CrossRefGoogle ScholarPubMed
Weisbrod, B., Test, M. & Stein, I. (1981). An alternative to mental hospital treatment. II. Economic cost-benefit analysis. Archives of General Psychiatry 37, 400405.CrossRefGoogle Scholar
Wyatt, R.J., Henter, I., Leary, M.C. & Taylor, E. (1995). An economic evaluation of schizophrenia. Social Psychiatry and Psychiatric Epidemiology 30, 196200.CrossRefGoogle ScholarPubMed
Yassa, R. & Jeste, D.V. (1992). Gender differences in tardive dyskinesia: a critical review of the literature. Schizophrenia Bulletin 18, 701715.CrossRefGoogle ScholarPubMed
Zwerling, I. (1976). The impact of the community mental health movement on psychiatric practice and training. Hospital and Community Psychiatry 27, 259263.Google ScholarPubMed