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Contemporary thinking about the role of genes and environment in eating disorders

Published online by Cambridge University Press:  11 October 2011

Cynthia M. Bulik  and
Federica Tozzi
Cynthia M. Bulik*
Affiliation:
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC (USA)
Federica Tozzi
Affiliation:
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC (USA)
*
Address for correspondence: Dr. C. Bulik, Department of Psychiatry, University of North Carolina at Chapel Hill, 1st floor Neurosciences Hospital, 101 Manning Drive, CB #7160, Chapel Hill, NC 27599-7160 (USA). Fax: +1-919-966.5628 E-mail: [email protected]
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Summary

Objective – To review recent literature documenting how family, twin and molecular genetic studies of eating disorders have revolutionized our conceptualizations of anorexia and bulimia nervosa. Methods – We summarized extant litera-ture on genetic epidemiology of eating disorders. Results – Results of extant studies highlight the underlying biological vulnera- bilities associated with these conditions. Genetic research has also opened up new avenues and approaches for exploring how the environment exerts its influence on risk. Conclusions – We discuss state-of-the-science findings in the genetics of eating disorders, explore various mechanisms of gene-environment interplay, and discuss implications of this research for science, practice, families and individuals with eating disorders.

Type
Invited Papers
Information
Epidemiology and Psychiatric Sciences , Volume 13 , Issue 2 , June 2004 , pp. 91 - 98
Copyright
Copyright © Cambridge University Press 2004

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References

REFERENCES

Abraham, S. (1996). Characteristics of eating disorders among young ballet dancers. Psychopathology 29, 223–229.CrossRefGoogle ScholarPubMed
Agras, S., Hammer, L. & McNicholas, F. (1999). A prospective study of the influence of eating-disordered mothers on their children. International Journal of Eating Disorders 25, 253–262.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Allison, D.B., Heo, M, Schork, N.J., Wong, S.L. & Elston, R.C. (1998). Extreme selection strategies in gene mapping studies of oligogenic quantitative traits do not always increase power. Human Heredity 48, 97–107.CrossRefGoogle Scholar
Ando, T., Komaki, G., Karibe, M., Kawamura, N., Hara, S., Takii, M., Naruo, T., Kurokawa, N., Takei, M., Tatsuta, N., Ohba, M, Nozoe, S., Kubo, C. & Ishikawa, T. (2001). 5-HT2A promoter polymorphism is not associated with anorexia nervosa in Japanese patients. Psychiatric Genetics 11, 157–160.CrossRefGoogle Scholar
Annenberg Adolescent Mental Health Initiative (2004). Retrieved March 30, 2004, from http://www.sunnylands.org/amhi/PrintVersion.aspGoogle Scholar
Barnes, J., Stein, A., Smith, T. & Pollock, J. I. (1997). Extreme attitudes to body shape, social and psychological factors and a reluctance to breast feed. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Journal of the Royal Society of Medicine 90, 551–559.CrossRefGoogle Scholar
Bergen, A.W., van den Bree, M.B., Yeager, M, Welch, R., Ganjei, J.K., Haque, K., Bacanu, S., Berrettini, W.H., Grice, D.E., Goldman, D., CM., Bulik, Klump, K., Fichter, M., Halmi, K., Kaplan, A., Strober, M., Treasure, J., Woodside, B. & Kaye, W. H. (2003a). Candidate genes for anorexia nervosa in the lp33-36 linkage region: serotonin ID and delta opioid receptor loci exhibit significant association to anorexia nervosa. Molecular Psychiatry 8, 397–406.CrossRefGoogle Scholar
Bergen, A.W., Yeager, M., Welch, R., Ganjei, J.K., Deep-Soboslay, A., Haque, K., van den Bree, M.B., Goldman, D., Berrettini, W.H. & Kaye, W.H. (2003b). Candidate gene analysis of the Price Foundation ano- rexia nervosa affected relative pair dataset. Current Drug Targets. CNS and Neurological Disorders 2, 41–51.CrossRefGoogle Scholar
Brinch, M., Isager, T. & Tolstrup, K. (1988). Anorexia nervosa and motherhood: reproduction pattern and mothering behavior of 50 women. Acta Psychiatrica Scandinavica 11, 611–617.CrossRefGoogle Scholar
Bulik, C.M., Sullivan, P.F., Fear, J. & Pickering, A. (1997). Predictors of the development of bulimia nervosa in women with anorexia nervo- sa. Journal of Nervous and Mental Disease 185, 704–707.CrossRefGoogle Scholar
Bulik, C.M., Sullivan, P.F., Wade, T.D. & Kendler, K.S. (2000). Twin studies of eating disorders: a review. International Journal of Eating Disorders 27, 1–20.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
Bulik, C.M., Devlin, B., Bacanu, S.A., Thornton, L., Klump, K.L., Fichter, M.M., Halmi, K.A., Kaplan, A.S., Strober, M., Woodside, D.B., Bergen, A.W., Ganjei, J.K., Crow, S., Mitchell, J., Rotondo, A., Mauri, M., Cassano, G., Keel, P., Berrettini, W.H. & Kaye, W.H. (2003). Significant linkage on chromosome lOp in families with bulimia nervosa. American Journal of Human Genetics 72, 200–207.CrossRefGoogle Scholar
Burnet, P.W., Smith, K.A., Cowen, P.J., Fairburn, C.G. & Harrison, P.J. (1999). Allelic variation of the 5-HT2C receptor (HTR2C) in buli- mia nervosa and binge eating disorder. Psychiatric Genetics 9, 101–104.CrossRefGoogle Scholar
Byrne, S. & McLean, N. (2001). Eating disorders in athletes: a review of the literature. Journal of Science and Medicine in Sport 4, 145–159.CrossRefGoogle ScholarPubMed
Campbell, D.A., Sundaramurthy, D., Markham, A.F. & Pieri, L.F. (1998). Lack of association between 5-HT2A gene promoter polymorphism and susceptibility to anorexia nervosa. Lancet 351, 499.CrossRefGoogle ScholarPubMed
Campbell, D.A., Sundaramurthy, D., Gordon, D., Markham, A.F. & Pieri, L.F. (1999). Association between a marker in the UCP-2/UCP-3 gene cluster and genetic susceptibility to anorexia nervosa. Molecular Psychiatry 4, 68–70.CrossRefGoogle ScholarPubMed
Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A. & Poulton, R. (2003). Influence of life stress on depression: moderation by a poly- morphism in the 5-HTT gene. Science 301, 386–389.CrossRefGoogle Scholar
Cnattingius, S., Hultman, C.M., Dahl, M. & Sparen, P. (1999). Very pre- term birth, birth trauma, and the risk of anorexia nervosa among girls. Archives of General Psychiatry 56, 634–638.CrossRefGoogle Scholar
Collier, D.A., Arranz, M.J., Li, T., Mupita, D., Brown, N. & Treasure, J. (1997). Association between 5-HT2A gene promoter polymorphism and anorexia nervosa. Lancet 350, 412.CrossRefGoogle ScholarPubMed
Devlin, B., Bacanu, S.A., Klump, K.L., Bulik, C.M., Fichter, M.M., Halmi, K.A., Kaplan, A.S., Strober, M., Treasure, J., Woodside, D.B., Berrettini, W.H. & Kaye, W. H. (2002). Linkage analysis of anorexia nervosa incorporating behavioral covariates. Human Molecular Genetics 11, 689–696.CrossRefGoogle ScholarPubMed
Di Bella, D.D., Catalano, M., Cavallini, M.C., Riboldi, C. & Bellodi, L. (2000). Serotonin transporter linked polymorphic region in anorexia nervosa and bulimia nervosa. Molecular Psychiatry 5, 233–234.CrossRefGoogle ScholarPubMed
Eastwood, H., Brown, K.M., Markovic, D. & Pieri, L.F. (2002). Variation in the ESR1 and ESR2 genes and genetic susceptibility to anorexia nervosa. Molecular Psychiatry 1, 86–89.CrossRefGoogle Scholar
Enoch, M.A., Kaye, W.H., Rotondo, A., Greenberg, B.D., Murphy, D.L. & Goldman, D. (1998). 5-HT2A promoter polymorphism -1438G/A, anorexia nervosa, and obsessive-compulsive disorder. Lancet 351, 1785–1786.CrossRefGoogle ScholarPubMed
Fairburn, C.G., Stein, A. & Jones, R. (1992). Eating habits and eating disorders during pregnancy. Psychosomatic Medicine 54, 665–672.CrossRefGoogle ScholarPubMed
Fumeron, F., Betoulle, D., Aubert, R., Herbeth, B., Siest, G. & Rigaud, D. (2001). Association of a functional 5-HT transporter gene poly- morphism with anorexia nervosa and food intake. Molecular Psychiatry 6, 9–10.CrossRefGoogle Scholar
Gabrovsek, M., Brecelj-Anderluh, M., Bellodi, L., Cellini, E., Di Bella, D., Estivill, X., Fernandez-Aranda, F., Freeman, B., Geller, F., Gratacos, M., Haigh, R., Hebebrand, J., Hinney, A., Holliday, J., Hu, X., Karwautz, A., Nacmias, B., Ribases, M., Remschmidt, H., Komel, R., Sorbi, S., Tomori, M., Treasure, J., Wagner, G., Zhao, J. & Collier, D. A. (2004). Combined family trio and case-control analysis of the COMT Val158Met polymorphism in European patients with ano- rexia nervosa. American Journal of Medical Genetics 124B, 68–72.Google Scholar
Garner, D.M. & Garfinkel, P.E. (1980). Socio-cultural factors in the development of anorexia nervosa. Psychological Medicine 10, 647–656.CrossRefGoogle ScholarPubMed
Gershon, E., Schreiber, J., Hamovit, J., & et al., (1983). Anorexia nervo- sa and major affective disorders associated in families: A prelimi- nary report. In Childhood Psychopathology and Development (ed. Guze, S.B., Earls, F.J. and Barrett, J.E.), pp. 279–284. Raven Press: New York.Google Scholar
Gorwood, P., Ades, J., Bellodi, L., Cellini, E., Collier, D.A., Di Bella, D., Di Bernardo, M., Estivill, X., Fernandez-Aranda, F., Gratacos, M., Hebebrand, J., Hinney, A., Hu, X., Karwautz, A., Kipman, A., Mouren-Simeoni, M.C., Nacmias, B., Ribases, M., Remschmidt, H., Ricca, V., Rotella, C.M., Sorbi, S. & Treasure, J. (2002). The 5-HT(2A) - 1438G/A polymorphism in anorexia nervosa: a combined analysis of 316 trios from six European centres. Molecular Psychiatry 7, 90–94.CrossRefGoogle ScholarPubMed
Grice, D.E., Halmi, K.A., Fichter, MM, Strober, M, Woodside, D.B., Treasure, J.T., Kaplan, A. S., Magistretti, P.J., Goldman, D., Bulik, C.M., Kaye, W.H. & Berrettini, W.H. (2002). Evidence for a suscep- tibility gene for anorexia nervosa on chromosome 1. American Journal of Human Genetics 70, 787–792.CrossRefGoogle Scholar
Hinney, A., Barth, N., Ziegler, A., von Prittwitz, S., Hamann, A., Hennighausen, K., Pirke, K. M., Heils, A., Rosenkranz, K., Roth, H., Coners, H., Mayer, H., Herzog, W., Siegfried, A., Lehmkuhl, G., Poustka, F., Schmidt, M.H., Schafer, H., Grzeschik, K.H., Lesch, K.P., Lentes, K. U., Remschmidt, H. & Hebebrand, J. (1997a). Serotonin transporter gene-linked polymorphic region: allele distributions in relationship to body weight and in anorexia nervosa. Life Science 61, L–303.Google ScholarPubMed
Hinney, A., Ziegler, A., Nothen, M.M., Remschmidt, H. & Hebebrand, J. (1997b). 5-HT2A receptor gene polymorphisms, anorexia nervosa, and obesity. Lancet 350, 1324–1325.CrossRefGoogle ScholarPubMed
Hu, X., Giotakis, O., Li, T., Karwautz, A.Treasure, J. & Collier, D.A. (2003). Association of the 5-HT2c gene with susceptibility and minimum body mass index in anorexia nervosa. Neuroreport 14, 781–783.CrossRefGoogle ScholarPubMed
Hudson, J.I., Pope, H.G. Jr., Jonas, J.M., Yurgelun-Todd, D. & Frankenburg, F.R. (1987). A controlled family history study of buli- mia. Psychological Medicine 17, 883–890.CrossRefGoogle Scholar
Karwautz, A., Rabe-Hesketh, S., Hu, X., Zhao, J., Sham, P., Collier, D.A. & Treasure, J.L. (2001). Individual-specific risk factors for anorexia nervosa: a pilot study using a discordant sister-pair design. Psychological Medicine 31, 317–329.CrossRefGoogle ScholarPubMed
Kassett, J.A., Gershon, E.S., Maxwell, M.E., Guroff, J.J., Kazuba, D.M., Smith, A.L., Brandt, H. A. & Jimerson, D.C. (1989). Psychiatric disorders in the first-degree relatives of probands with bulimia ner-vosa. American Journal of Psychiatry 146, 1468–1471.Google Scholar
Kaye, W.H., Lilenfeld, L.R., Berrettini, W.H., Strober, M., Devlin, B., Klump, K.L., Goldman, D., Bulik, C.M., Halmi, K.A., Fichter, M.M., Kaplan, A., Woodside, D.B., Treasure, J., Plotnicov, K.H., Pollice, C., Rao, R. & McConaha, C.W. (2000). A search for susceptibility loci for anorexia nervosa: methods and sample description. Biological Psychiatry 47, 794–803.CrossRefGoogle ScholarPubMed
Keel, P.K. & Klump, K.L. (2003). Are eating disorders culture-bound syndromes? Implications for conceptualizing their etiology. Psychological Bulletin 129, 747–769.CrossRefGoogle ScholarPubMed
Kendler, K.S. (2001). Twin studies of psychiatric illness: an update. Archives of General Psychiatry 58, 1005–1014.CrossRefGoogle ScholarPubMed
Kendler, K.S., MacLean, C., Neale, M., Kessler, R., Heath, A. & Eaves, L. (1991). The genetic epidemiology of bulimia nervosa. American Journal of Psychiatry 148, 1627–1637.Google ScholarPubMed
Kendler, K.S., Neale, M.C., Kessler, R.C., Heath, A.C & Eaves, L.J. (1993). A test of the equal-environment assumption in twin studies of psychiatric illness. Behavior Genetics 23, 21–27.CrossRefGoogle ScholarPubMed
King, M.B. & Mezey, G. (1987). Eating behaviour of male racing jockeys. Psychological Medicine 17, 249–253.CrossRefGoogle ScholarPubMed
Klump, K.L., Holly, A., Iacono, W.G., McGue, M. & Willson, L.E. (2000). Physical similarity and twin resemblance for eating attitudes and behaviors: a test of the equal environments assumption. Behavior Genetics 30, 51–58.CrossRefGoogle ScholarPubMed
Klump, K.L., Miller, K.B., Keel, P.K., McGue, M. & Iacono, W.G. (2001). Genetic and environmental influences on anorexia nervosa syndro- mes in a population-based twin sample. Psychological Medicine 31, 737–740.CrossRefGoogle Scholar
Koronyo-Hamaoui, M., Danziger, Y., Frisch, A., Stein, D., Leor, S., Laufer, N., Carel, C., Fennig, S., Minoumi, M., Apter, A., Goldman, B., Barkai, G., Weizman, A. & Gak, E. (2002). Association between anorexia nervosa and the hsKCa3 gene: a family-based and case control study. Molecular Psychiatry 7, 82–85.CrossRefGoogle ScholarPubMed
Kortegaard, L.S., Hoerder, K., Joergensen, J., Gillberg, C. & Kyvik, K. O. (2001). A preliminary population-based twin study of self-reported eating disorder. Psychological Medicine 31, 361–365.CrossRefGoogle ScholarPubMed
Krieg, J.C, Lauer, C. & Pirke, K.M. (1987). Hormonal and metabolic mechanisms in the development of cerebral pseudoatrophy in eating disorders. Psychotherapy and Psychosomatics 48, 176–180.CrossRefGoogle ScholarPubMed
Lacey, J.H. & Smith, G. (1987). Bulimia nervosa. The impact of pre- gnancy on mother and baby. British Journal of Psychiatry 150, 777–781.CrossRefGoogle Scholar
Lilenfeld, L.R., Kaye, W.H., Greeno, C.G., Merikangas, K.R., Plotnicov, K., Pollice, C., Rao, R., Strober, M., Bulik, C.M. & Nagy, L. (1998). A controlled family study of anorexia nervosa and bulimia nervosa: psychiatric disorders in first-degree relatives and effects of proband comorbidity. Archives of General Psychiatry 55, 603–610.CrossRefGoogle ScholarPubMed
Lilenfeld, L.R., Stein, D., Bulik, C.M., Strober, M., Plotnicov, K., Pollice, C, Rao, R., Merikangas, K.R., Nagy, L. & Kaye, W.H. (2000). Personality traits among currently eating disordered, recovered and never ill first-degree female relatives of bulimic and control women. Psychological Medicine 30, 1399–1410.CrossRefGoogle ScholarPubMed
Manolakou, K., Beaton, J., McConnell, I., Farquar, C., Manson, J., Hastie, N.D., Bruce, M. & Jackson, I.J. (2001). Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice. Proceedings of the National Academy of Sciences of the United States of America 98, 7402–7407.CrossRefGoogle ScholarPubMed
Mashimo, T., Lucas, M., Simon-Chazottes, D., Frenkiel, M.P., Montagutelli, X., Ceccaldi, P.E., Deubel, V., Guenet, J.L. & Despres, P. (2002). A nonsense mutation in the gene encoding 2'-5'-oligoa-denylate synthetase/Ll isoform is associated with West Nile virus susceptibility in laboratory mice. Proceedings of the National Academy of Sciences of the United States of America 99, 11311–11316.CrossRefGoogle Scholar
Minuchin, S., Rosman, B.L. & Baker, L. (1978). Psychosomatic Families: Anorexia Nervosa in Context. Harvard University Press: Cambridge, Massachussets.CrossRefGoogle Scholar
Mitchell, J., Seim, H.C., Glotter, D., Soil, E.A. & Pike, R. L. (1991). A retrospective study of pregnancy in bulimia nervosa. International Journal of Eating Disorders 10, 209–214.3.0.CO;2-S>CrossRefGoogle Scholar
Mitchell-Gieleghem, A., Mittelstaedt, M.E. & Bulik, C. M. (2002). Eating disorders and childbearing: concealment and consequences. Birth 29, 182–191.CrossRefGoogle ScholarPubMed
Nacmias, B., Ricca, V., Tedde, A., Mezzani, B., Rotella, C.M. & Sorbi, S. (1999). 5-HT2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa. Neuroscience Letters 277, 134–136.CrossRefGoogle ScholarPubMed
Nilsson, M., Naessen, S., Dahlman, I., Linden, H.A., Gustafsson, J.A. & Dahlman-Wright, K. (2004). Association of estrogen receptor beta gene polymorphisms with bulimic disease in women. Molecular Psychiatry 9, 28–34.CrossRefGoogle ScholarPubMed
Nishiguchi, N., Matsushita, S., Suzuki, K., Murayama, M., Shirakawa, O. & Higuchi, S. (2001). Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients. Biological Psychiatry 50, 123–128.CrossRefGoogle ScholarPubMed
Park, R.J., Senior, R. & Stein, A. (2003). The offspring of mothers with eating disorders. European Child & Adolescent Psychiatry 12, Suppl. 1, 1110–1119.CrossRefGoogle ScholarPubMed
Plomin, R., DeFries, J.C. & Loehlin, J.C. (1977). Genotype-environment interaction and correlation in the analysis of human behavior. Psychological Bulletin 84, 309–322.CrossRefGoogle ScholarPubMed
Pratt, B.M. & Woolfenden, S.R. (2002). Interventions for preventing eating disorders in children and adolescents. Cochrane Database of Systematic Reviews CDO02891.CrossRefGoogle Scholar
Ricca, V., Nacmias, B., Cellini, E., Di Bernardo, M., Rotella, C.M. & Sorbi, S. (2002). 5-HT2A receptor gene polymorphism and eating disor- ders. Neuroscience Letters 323, 105–108.CrossRefGoogle Scholar
Rosenkranz, K., Hinney, A., Ziegler, A., Hermann, H., Fichter, M., Mayer, H., Siegfried, W., Young, J.K., Remschmidt, H. & Hebebrand, J. (1998). Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: identification of several genetic variants. Journal of Clinical Endocrinology and Metabolism 83, 4524–4527.CrossRefGoogle ScholarPubMed
Rutherford, J., McGuffin, P., Katz, R.J. & Murray, R.M. (1993). Genetic influences on eating attitudes in a normal female twin population. Psychological Medicine 23, 425–436.CrossRefGoogle Scholar
Rutter, M. & Silberg, J. (2002). Gene-environment interplay in relation to emotional and behavioral disturbance. Annual Review of Psychology 53, 463–490.CrossRefGoogle ScholarPubMed
Sasieni, P.D. (1997). From genotypes to genes: doubling the sample size. Biometrics 53, 1253–1261.CrossRefGoogle ScholarPubMed
Sham, P.C. (1998). Statistical methods in psychiatric genetics. Statistical Methods in Medical Research 7, 279–300.CrossRefGoogle ScholarPubMed
Slof, R., Mazzeo, S. & Bulik, C.M. (2003). Characteristics of women with persistent thinness. Obesity Research 11, 971–977.CrossRefGoogle ScholarPubMed
Sorbi, S., Nacmias, B., Tedde, A., Ricca, V., Mezzani, B. & Rotella, C.M. (1998). 5-HT2A promoter polymorphism in anorexia nervosa. Lancet 351, 1785.CrossRefGoogle ScholarPubMed
Sours, J.A. (1974). The anorexia nervosa syndrome. International Journal of Psychoanalysis 55, 567–579.Google ScholarPubMed
Stein, A. & Fairburn, C.G. (1989). Children of mothers with bulimia ner- vosa. British Medical Journal 299, 777–778.CrossRefGoogle Scholar
Stein, A., Woolley, H., Cooper, S.D. & Fairburn, C.G. (1994). An obser- vational study of mothers with eating disorders and their infants. Journal of Child Psychology and Psychiatry, and Allied Disciplines 35, 733–748.CrossRefGoogle Scholar
Strober, M., Freeman, R., Lampert, C., Diamond, J. & Kaye, W. (2000). Controlled family study of anorexia nervosa and bulimia nervosa: evidence of shared liability and transmission of partial syndromes. American Journal of Psychiatry 157, 393–401.CrossRefGoogle ScholarPubMed
Sullivan, P.F., Bulik, C.M. & Kendler, K.S. (1998). Genetic epidemio- logy of binging and vomiting. British Journal of Psychiatry 173, 75–79.CrossRefGoogle Scholar
Sundaramurthy, D., Pieri, L.F., Gape, H., Markham, A.F. & Campbell, D.A. (2000). Analysis of the serotonin transporter gene linked poly- morphism (5-HTTLPR) in anorexia nervosa. American Journal of Medical Genetics 96, 53–55.3.0.CO;2-X>CrossRefGoogle Scholar
Sundgot-Borgen, J. & Torstveit, M.K. (2004). Prevalence of eating disor- ders in elite athletes is higher than in the general population. Clinical Journal of Sport Medicine 14, 25–32.CrossRefGoogle Scholar
Tozzi, F., Aggen, S.H., Neale, B.M., Anderson, C.B., Mazzeo, S.E., Neale, M.C. & Bulik, C.M. (in press). The structure of perfectionism: a twin study. Behavior Genetics.Google Scholar
Tozzi, F., Thornton, L.M., Klump, K.L., Bulik, C.M., Fichter, M.M., Halmi, K., Kaplan, A., Strober, M., Woodside, B., Crow, S., Mitchell, J., Rotondo, A., Mauri, M., Cassano, G., Keel, P., Plotnicov, K., Pollice, C., Lilenfeld, L.R., Berrettini, W.H. & Kaye, W. (submitted for publi- cation). Symptom fluctuation in eating disorders: correlates of dia- gnostic crossover.Google Scholar
Treasure, J.L. & Russell, G.F. (1988). Intrauterine growth and neonatal weight gain in babies of women with anorexia nervosa. British MedicalJournal (Clinical Research Ed.) 296, 1038.CrossRefGoogle ScholarPubMed
Urwin, R.E., Bennetts, B., Wilcken, B., Lampropoulos, B., Beumont, P., Clarke, S., Russell, J., Tanner, S. & Nunn, K.P. (2002). Anorexia ner- vosa (restrictive subtype) is associated with a polymorphism in the novel norepinephrine transporter gene promoter polymorphic region. Molecular Psychiatry 7, 652–657.CrossRefGoogle Scholar
Urwin, R.E., Bennetts, B.H., Wilcken, B., Beumont, P.J., Russell, J.D. & Nunn, K.P. (2003a). Investigation of epistasis between the serotonin transporter and norepinephrine transporter genes in anorexia nervo- sa. Neuropsychopharmacology 28, 1351–1355.CrossRefGoogle Scholar
Urwin, R.E., Bennetts, B.H., Wilcken, B., Lampropoulos, B., Beumont, P.J., Russell, J.D., Tanner, S.L. & Nunn, K.P. (2003b). Gene-gene interaction between the monoamine oxidase A gene and solute car- rier family 6 (neurotransmitter transporter, noradrenalin) member 2 gene in anorexia nervosa (restrictive subtype). European Journal of Human Genetics 11, 945–950.CrossRefGoogle Scholar
van der Spuy, Z.M., Steer, P.J., McCusker, M., Steele, S.J. & Jacobs, H.S. (1988). Outcome of pregnancy in underweight women after sponta- neous and induced ovulation. British Medical Journal (Clinical Research Ed.) 296, 962–965.CrossRefGoogle Scholar
Vink, T., Hinney, A., van Elburg, A.A., van Goozen, S.H., Sandkuijl, L.A., Sinke, R.J., Herpertz-Dahlmann, B.M., Hebebrand, J., Remschmidt, H., van Engeland, H. & Adan, R.A. (2001). Association between an agouti-related protein gene polymorphism and anorexia nervosa. Molecular Psychiatry 6, 325–328.CrossRefGoogle ScholarPubMed
Wade, T., Martin, N.G., Neale, M.C, Tiggemann, M., Treloar, S.A., Bucholz, K.K., Madden, P. A. & Heath, A.C. (1999). The structure of genetic and environmental risk factors for three measures of disor- dered eating. Psychological Medicine 29, 925–934.CrossRefGoogle Scholar
Wade, T.D., Bulik, C.M., Neale, M. & Kendler, K.S. (2000). Anorexia nervosa and major depression: shared genetic and environmental risk factors. American Journal of Psychiatry 157, 469–471.CrossRefGoogle ScholarPubMed
Wade, T.D., Bulik, C.M., Heath, A.C.Martin, N.G. & Eaves, L.J. (2001). The influence of genetic and environmental factors in estimations of current body size, desired body size, and body dissatisfaction. Twin Research 4, 260–265.CrossRefGoogle ScholarPubMed
Walters, E.E. & Kendler, K.S. (1995). Anorexia nervosa and anorexic- like syndromes in a population-based female twin sample. American Journal of Psychiatry 152, 64–71.Google Scholar
Waugh, E. & Bulik, C.M. (1999). Offspring of women with eating disor- ders. International Journal of Eating Disorders 25, 123–133.3.0.CO;2-B>CrossRefGoogle Scholar
Westberg, L., Bah, J., Rastam, M., Gillberg, C., Wentz, E., Melke, J., Hellstrand, M. & Eriksson, E. (2002). Association between a poly-morphism of the 5-HT2C receptor and weight loss in teenage girls. Neuropsychopharmacology 26, 789–793.CrossRefGoogle Scholar
Woodside, D.B., Bulik, C.M., Halmi, K.A., Fichter, M.M., Kaplan, A., Berrettini, W.H., Strober, M., Treasure, J., Lilenfeld, L., Klump, K. & Kaye, W.H. (2002). Personality, perfectionism, and attitudes toward eating in parents of individuals with eating disorders. International Journal of Eating Disorders 31, 290–299.CrossRefGoogle ScholarPubMed
Ziegler, A., Hebebrand, J., Gorg, T., Rosenkranz, K., Fichter, M., Herpertz-Dahlmann, B., Remschmidt, H. & Hinney, A. (1999). Further lack of association between the 5-HT2A gene promoter polymorphism and susceptibility to eating disorders and a meta- analysis pertaining to anorexia nervosa. Molecular Psychiatry 4, 410–412.CrossRefGoogle Scholar