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Treating co-morbid chronic medical conditions and anxiety/depression

Part of: Special Articles

Published online by Cambridge University Press:  08 April 2011

D. Cimpean  and
R. E. Drake
D. Cimpean*
Affiliation:
Dartmouth Psychiatric Research Center, NH, USA
R. E. Drake
Affiliation:
Dartmouth Psychiatric Research Center, NH, USA
*
*Address for correspondence: D. Cimpean M.D., Dartmouth Hitchcock Medical Center, General Internal Medicine-Lyme, One Medical Center Drive, Lebanon, NH 03756, USA. (Email: [email protected])
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Abstract

Aims.

This systematic review examines interventions for care of people with co-morbid chronic medical illness and anxiety/depression disorders – a group with high risks for morbidity and mortality.

Methods.

Systematic search of Medline 1995 to January 2011 for randomized controlled trials of treatment interventions designed for adult outpatients with diagnosed chronic medical illness (diabetes mellitus, cardiovascular disorders, and chronic respiratory disorders) and anxiety/depression disorders.

Results.

Six trials studied complex interventions based on the chronic care model, and eight trials studied psychosocial interventions. Most interventions addressed the mental health aspect of the co-morbidity and showed improvements in anxiety/depression but not in the co-morbid medical disorder.

Conclusions.

Further research might focus on interventions integrating mental health treatment with enhanced medical care components, incorporating shared-decision making and information technology advances.

Keywords

Anxiety disorderschronic diseaseco-morbiditydepressive disorders
Type
Special Article
Information
Epidemiology and Psychiatric Sciences , Volume 20 , Issue 2 , June 2011 , pp. 141 - 150
Copyright
Copyright © Cambridge University Press 2011

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References

Adams, PF, Barnes, PM, Vickerie, JL, National Health Interview Survey (USA), National Center for Health Statistics (USA). Division of Health Interview Statistics. (2009). Summary Health Statistics for the US Population: National Health Interview Survey, 2008: data from the National Health Interview Survey. US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics: Hyattsville, MD.Google ScholarPubMed
Bartels, SJ (2004). Caring for the whole person: integrated health care for older adults with severe mental illness and medical comorbidity. Journal of American Geriatric Society 52, S249–57.CrossRefGoogle ScholarPubMed
Bartels, SJ, Coakley, EH, Zubritsky, C, Ware, JH, Miles, KM, Arean, PA, Chen, H, Oslin, DW, Llorente, MD, Costantino, G, Quijano, L, McIntyre, JS, Linkins, KW, Oxman, TE, Maxwell, J, Levkoff, SE, Investigators, PE (2004). Improving access to geriatric mental health services: a randomized trial comparing treatment engagement with integrated versus enhanced referral care for depression, anxiety, and at-risk alcohol use. American Journal of Psychiatry 161, 1455–1462.CrossRefGoogle ScholarPubMed
Berkman, LF, Blumenthal, J, Burg, M, Carney, RM, Catellier, D, Cowan, MJ, Czajkowski, SM, DeBusk, R, Hosking, J, Jaffe, A, Kaufmann, PG, Mitchell, P, Norman, J, Powell, LH, Raczynski, JM, Schneiderman, N (2003). Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial. JAMA: The Journal of the American Medical Association 289, 3106–3116.Google ScholarPubMed
Bodenheimer, T, Wagner, EH, Grumbach, K (2002). Improving primary care for patients with chronic illness. JAMA: The Journal of the American Medical Association 288, 1775–1779.CrossRefGoogle ScholarPubMed
Bogner, HR, Morales, KH, Post, EP, Bruce, ML (2007). Diabetes, depression, and death: a randomized controlled trial of a depression treatment program for older adults based in primary care (PROSPECT). Diabetes Care 30, 3005–3010.CrossRefGoogle Scholar
Bowen, RC, Senthilselvan, A, Barale, A (2000). Physical illness as an outcome of chronic anxiety disorders. Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie 45, 459–464.CrossRefGoogle ScholarPubMed
Bruce, ML, Ten Have, TR, Reynolds, CF III, Katz, II, Schulberg, HC, Mulsant, BH, Brown, GK, McAvay, GJ, Pearson, JL, Alexopoulos, GS (2004). Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial. JAMA: The Journal of the American Medical Association 291, 1081–1091.CrossRefGoogle ScholarPubMed
Carney, RM, Blumenthal, JA, Freedland, KE, Youngblood, M, Veith, RC, Burg, MM, Cornell, C, Saab, PG, Kaufmann, PG, Czajkowski, SM, Jaffe, AS (2004). Depression and late mortality after myocardial infarction in the Enhancing Recovery in Coronary Heart Disease (ENRICHD) study. Psychosomatic Medicine 66, 466–474.CrossRefGoogle ScholarPubMed
Carroll, D, Phillips, AC, Thomas, GN, Gale, CR, Deary, I, Batty, GD (2009). Generalized anxiety disorder is associated with metabolic syndrome in the Vietnam experience study. Biological Psychiatry 66, 91–93.CrossRefGoogle ScholarPubMed
Chin, MH, Cook, S, Drum, ML, Jin, L, Guillen, M, Humikowski, CA, Koppert, J, Harrison, JF, Lippold, S, Schaefer, CT (2004). Improving diabetes care in midwest community health centers with the health disparities collaborative. Diabetes Care 27, 2–8.CrossRefGoogle ScholarPubMed
Cimpean, D, Carpenter-Song, E, Oliver, B, Brooks, B, Bartels, S, Drake, R (2010). Experiences of people with chronic medical illness and depression/anxiety – a Qualitative Study, Poster. In Society of General Internal Medicine New England Regional Meeting. Providence, RI.Google Scholar
Clarke, DM, Currie, KC (2009). Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence. Medical Journal of Australia 190, S54–S60.CrossRefGoogle ScholarPubMed
Coleman, K, Austin, BT, Brach, C, Wagner, EH (2009 a). Evidence on the chronic care model in the new millennium. Health Affairs (Millwood) 28, 75–85.CrossRefGoogle ScholarPubMed
Coleman, K, Mattke, S, Perrault, PJ, Wagner, EH (2009 b). Untangling practice redesign from disease management: how do we best care for the chronically ill? Annual Review of Public Health 30, 385–408.CrossRefGoogle ScholarPubMed
Davidson, KW, Rieckmann, N, Clemow, L, Schwartz, JE, Shimbo, D, Medina, V, Albanese, G, Kronish, I, Hegel, M, Burg, MM (2010). Enhanced depression care for patients with acute coronary syndrome and persistent depressive symptoms: coronary psychosocial evaluation studies randomized controlled trial. Archives of Internal Medicine 170, 600–608.CrossRefGoogle ScholarPubMed
Dennis, SM, Zwar, N, Griffiths, R, Roland, M, Hasan, I, Powell Davies, G, Harris, M (2008). Chronic disease management in primary care: from evidence to policy. Medical Journal of Australia 188, S53–S56.CrossRefGoogle ScholarPubMed
Denollet, J, Maas, K, Knottnerus, A, Keyzer, JJ, Pop, VJ (2009). Anxiety predicted premature all-cause and cardiovascular death in a 10-year follow-up of middle-aged women. Journal of Clinical Epidemiology 62, 452–456.CrossRefGoogle Scholar
Drake, RE, Deegan, PE, Woltmann, E, Haslett, W, Drake, T, Rapp, CA (2010). Comprehensive electronic decision support systems. Psychiatric Services 61, 714–717.CrossRefGoogle ScholarPubMed
Druss, BG, Newcomer, JW (2007). Challenges and solutions to integrating mental and physical health care. Journal of Clinical Psychiatry 68, e09.Google ScholarPubMed
Ell, K, Katon, W, Xie, B, Lee, PJ, Kapetanovic, S, Guterman, J, Chou, CP (2010). Collaborative care management of major depression among low-income, predominantly Hispanic subjects with diabetes: a randomized controlled trial. Diabetes Care 33, 706–713.CrossRefGoogle ScholarPubMed
Fan, AZ, Strine, TW, Jiles, R, Mokdad, AH (2008). Depression and anxiety associated with cardiovascular disease among persons aged 45 years and older in 38 states of the United States, 2006. Preventive Medicine 46, 445–450.CrossRefGoogle Scholar
Felker, BL, Barnes, RF, Greenberg, DM, Chaney, EF, Shores, MM, Gillespie-Gateley, L, Buike, MK, Morton, CE (2004). Preliminary outcomes from an integrated mental health primary care team. Psychiatric Services 55, 442–444.CrossRefGoogle ScholarPubMed
Frasure-Smith, N, Lesperance, F (2008). Depression and anxiety as predictors of 2-year cardiac events in patients with stable coronary artery disease. Archives of General Psychiatry 65, 62–71.CrossRefGoogle ScholarPubMed
Friedmann, E, Thomas, SA, Liu, F, Morton, PG, Chapa, D, Gottlieb, SS, Sudden Cardiac Death in Heart Failure Trial Investigators. (2006). Relationship of depression, anxiety, and social isolation to chronic heart failure outpatient mortality. American Heart Journal 152, 940.e1–940.e8.CrossRefGoogle ScholarPubMed
Gaynes, BN, Burns, BJ, Tweed, DL, Erickson, P (2002). Depression and health-related quality of life. The Journal of Nervous and Mental Disease 190, 799–806.CrossRefGoogle ScholarPubMed
Goldman, LS (1999). Medical illness in patients with schizophrenia. Journal of Clinical Psychiatry 60, 10–15.Google ScholarPubMed
Green, CJ, Fortin, P, Maclure, M, Macgregor, A, Robinson, S (2006). Information system support as a critical success factor for chronic disease management: Necessary but not sufficient. International Journal of Medical Informatics 75, 818–828.CrossRefGoogle Scholar
Harkness, EF, Bower, PJ (2009). On-site mental health workers delivering psychological therapy and psychosocial interventions to patients in primary care: effects on the professional practice of primary care providers. Cochrane Database Systematic Reviews: CD000532.CrossRefGoogle ScholarPubMed
Harter, MC, Conway, KP, Merikangas, KR (2003). Associations between anxiety disorders and physical illness. European Archives of Psychiatry and Clinical Neuroscience 253, 313–320.CrossRefGoogle ScholarPubMed
Hoffman, C, Rice, D, Sung, HY (1996). Persons with chronic conditions. Their prevalence and costs. JAMA: The Journal of the American Medical Association 276, 1473–1479.CrossRefGoogle ScholarPubMed
Hogan, P, Dall, T, Nikolov, P (2003). Economic costs of diabetes in the US in 2002. Diabetes Care 26, 917–932.Google ScholarPubMed
Huibers, MJ, Beurskens, AJ, Bleijenberg, G, van Schayck, CP (2007). Psychosocial interventions by general practitioners. Cochrane Database Of Systematic Reviews (Online), CD003494.CrossRefGoogle ScholarPubMed
Hynninen, MJ, Bjerke, N, Pallesen, S, Bakke, PS, Nordhus, IH (2010). A randomized controlled trial of cognitive behavioral therapy for anxiety and depression in COPD. Respiratory Medicine 104, 986–994.CrossRefGoogle ScholarPubMed
Institute of Medicine (USA). Committee on Crossing the Quality Chasm: Adaptation to Mental Health and Addictive Disorders. (2006). Improving the Quality of Health care for Mental and Substance-use Conditions. National Academy Press: Washington, DC.Google Scholar
Jemal, A, Ward, E, Hao, Y, Thun, M (2005). Trends in the leading causes of death in the United States, 1970–2002. JAMA : The Journal of the American Medical Association 294, 1255–1259.CrossRefGoogle ScholarPubMed
Kahn, LS, Fox, CH, McIntyre, RS, Tumiel-Berhalter, L, Berdine, DE, Lyle, H (2008). Assessing the prevalence of depression among individuals with diabetes in a Medicaid managed-care program. International Journal of Psychiatry in Medicine 38, 13–29.CrossRefGoogle Scholar
Katon, W, Ciechanowski, P (2002). Impact of major depression on chronic medical illness. Journal of Psychosomatic Research 53, 859–863.CrossRefGoogle ScholarPubMed
Katon, W, von Korff, M, Ciechanowski, P, Russo, J, Lin, E, Simon, G, Ludman, E, Walker, E, Bush, T, Young, B (2004a). Behavioral and clinical factors associated with depression among individuals with diabetes. Diabetes Care 27, 914–920.CrossRefGoogle ScholarPubMed
Katon, WJ, Russo, JE, Von Korff, M, Lin, EH, Ludman, E, Ciechanowski, PS (2008). Long-term effects on medical costs of improving depression outcomes in patients with depression and diabetes. Diabetes Care 31, 1155–1159.CrossRefGoogle ScholarPubMed
Katon, WJ, Von Korff, M, Lin, EH, Simon, G, Ludman, E, Russo, J, Ciechanowski, P, Walker, E, Bush, T (2004b). The Pathways Study: a randomized trial of collaborative care in patients with diabetes and depression. Archives of General Psychiatry 61, 1042–1049.CrossRefGoogle ScholarPubMed
Kessler, RC, Berglund, P, Demler, O, Jin, R, Merikangas, KR, Walters, EE (2005 a). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry 62, 593–602.CrossRefGoogle ScholarPubMed
Kessler, RC, Chiu, WT, Demler, O, Merikangas, KR, Walters, EE (2005 b). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry; Archives of General Psychiatry 62, 617–627.CrossRefGoogle ScholarPubMed
Kinder, LS, Katon, WJ, Ludman, E, Russo, J, Simon, G, Lin, EH, Ciechanowski, P, Von Korff, M, Young, B (2006). Improving depression care in patients with diabetes and multiple complications. Journal of General Internal Medicine 21, 1036–1041.CrossRefGoogle ScholarPubMed
Kotecha, JA, Birtwhistle, RV (2009). Use of electronic medical records: reminders and decision aids for chronic disease management. Canadian Family Physician 55, 899.Google ScholarPubMed
Kunik, ME, Roundy, K, Veazey, C, Souchek, J, Richardson, P, Wray, NP, Stanley, MA (2005). Surprisingly high prevalence of anxiety and depression in chronic breathing disorders. Chest 127, 1205–1211.Google ScholarPubMed
Kunik, ME, Veazey, C, Cully, JA, Souchek, J, Graham, DP, Hopko, D, Carter, R, Sharafkhaneh, A, Goepfert, EJ, Wray, N, Stanley, MA (2008). COPD education and cognitive behavioral therapy group treatment for clinically significant symptoms of depression and anxiety in COPD patients: a randomized controlled trial. Psychology Medicine 38, 385–396.CrossRefGoogle ScholarPubMed
Lamers, F, Jonkers, CC, Bosma, H, Kempen, GI, Meijer, JA, Penninx, BW, Knottnerus, JA, van Eijk, JT (2010). A minimal psychological intervention in chronically ill elderly patients with depression: a randomized trial. Psychotherapy Psychosomatics 79, 217–226.CrossRefGoogle ScholarPubMed
Lesman-Leegte, I, Jaarsma, T, Coyne, JC, Hillege, HL, Van Veldhuisen, DJ, Sanderman, R (2009). Quality of life and depressive symptoms in the elderly: a comparison between patients with heart failure and age- and gender-matched community controls. Journal of Cardiology Failure 15, 17–23.CrossRefGoogle ScholarPubMed
Lesperance, F, Frasure-Smith, N, Koszycki, D, Laliberte, MA, van Zyl, LT, Baker, B, Swenson, JR, Ghatavi, K, Abramson, BL, Dorian, P, Guertin, MC (2007). Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial. JAMA: The Journal of the American Medical Association 297, 367–379.CrossRefGoogle ScholarPubMed
Lin, EH, Katon, W, Rutter, C, Simon, GE, Ludman, EJ, Von Korff, M, Young, B, Oliver, M, Ciechanowski, PC, Kinder, L, Walker, E (2006). Effects of enhanced depression treatment on diabetes self-care. Annals of Family Medicine 4, 46–53.CrossRefGoogle ScholarPubMed
Lin, EH, Rutter, CM, Katon, W, Heckbert, SR, Ciechanowski, P, Oliver, MM, Ludman, EJ, Young, BA, Williams, LH, McCulloch, DK, Von Korff, M (2010). Depression and advanced complications of diabetes: a prospective cohort study. Diabetes Care 33, 264–269.CrossRefGoogle ScholarPubMed
Lincoln, NB, Flannaghan, T (2003). Cognitive behavioral psychotherapy for depression following stroke: a randomized controlled trial. Stroke 34, 111–115.CrossRefGoogle ScholarPubMed
Lustman, PJ, Clouse, RE, Ciechanowski, PS, Hirsch, IB, Freedland, KE (2005). Depression-related hyperglycemia in type 1 diabetes: a mediational approach. Psychosomatic Medicine 67, 195–199.CrossRefGoogle ScholarPubMed
Lustman, PJ, Griffith, LS, Freedland, KE, Kissel, SS, Clouse, RE (1998). Cognitive behavior therapy for depression in type 2 diabetes mellitus. A randomized, controlled trial. Annals of Internal Medicine 129, 613–621.CrossRefGoogle ScholarPubMed
Mattke, S, Seid, M, Ma, S (2007). Evidence for the effect of disease management: is $1 billion a year a good investment? American Journal of Managed Care 13, 670–676.Google Scholar
Maurer, J, Rebbapragada, V, Borson, S, Goldstein, R, Kunik, ME, Yohannes, AM, Hanania, NA (2008). Anxiety and depression in COPD: current understanding, unanswered questions, and research needs. Chest 134, 43S–56S.CrossRefGoogle ScholarPubMed
Montori, VM, Gafni, A, Charles, C (2006). A shared treatment decision-making approach between patients with chronic conditions and their clinicians: the case of diabetes. Health Expectations 9, 25–36.CrossRefGoogle ScholarPubMed
Morden, NE, Mistler, LA, Weeks, WB, Bartels, SJ (2009). Health care for patients with serious mental illness: family medicine's role. Journal of American Board Family Medicine 22, 187–195.CrossRefGoogle ScholarPubMed
Musselman, DL, Evans, DL, Nemeroff, CB (1998). The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment. Archives of General Psychiatry 55, 580–592.CrossRefGoogle ScholarPubMed
Phillips, AC, Batty, GD, Gale, CR, Deary, IJ, Osborn, D, MacIntyre, K, Carroll, D (2009). Generalized anxiety disorder, major depressive disorder, and their comorbidity as predictors of all-cause and cardiovascular mortality: the Vietnam experience study. Psychosomatic Medicine 71, 395–403.CrossRefGoogle ScholarPubMed
Pincus, HA (2006). Depression and primary care: drowning in the mainstream or left on the banks? Journal of Managed Care Pharmacy 12, 3–9.CrossRefGoogle ScholarPubMed
Pomerantz, A, Cole, BH, Watts, BV, Weeks, WB (2008). Improving efficiency and access to mental health care: combining integrated care and advanced access. General Hospital Psychiatry 30, 546–551.CrossRefGoogle ScholarPubMed
Rosamond, W, Flegal, K, Furie, K, Go, A, Greenlund, K, Haase, N, Hailpern, SM, Ho, M, Howard, V, Kissela, B, Kittner, S, Lloyd-Jones, D, McDermott, M, Meigs, J, Moy, C, Nichol, G, O'Donnell, C, Roger, V, Sorlie, P, Steinberger, J, Thom, T, Wilson, M, Hong, Y (2008). Heart disease and stroke statistics – 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 117, e25–146.Google ScholarPubMed
Ross, CJ, Davis, TM, MacDonald, GF (2005). Cognitive-behavioral treatment combined with asthma education for adults with asthma and coexisting panic disorder. Clinical Nursing Research 14, 131–157.CrossRefGoogle ScholarPubMed
Rutledge, T, Linke, SE, Krantz, DS, Johnson, BD, Bittner, V, Eastwood, JA, Eteiba, W, Pepine, CJ, Vaccarino, V, Francis, J, Vido, DA, Merz, CN (2009). Comorbid depression and anxiety symptoms as predictors of cardiovascular events: results from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. Psychosomatic Medicine 71, 958–964.CrossRefGoogle ScholarPubMed
Sambamoorthi, U, Olfson, M, Wei, W, Crystal, S (2006). Diabetes and depression care among medicaid beneficiaries. Journal of Health Care for the Poor and Underserved 17, 141–161.CrossRefGoogle ScholarPubMed
Scott, KM, Bruffaerts, R, Tsang, A, Ormel, J, Alonso, J, Angermeyer, MC, Benjet, C, Bromet, E, de Girolamo, G, de Graaf, R, Gasquet, I, Gureje, O, Haro, JM, He, Y, Kessler, RC, Levinson, D, Mneimneh, ZN, Oakley Browne, MA, Posada-Villa, J, Stein, DJ, Takeshima, T, Von Korff, M (2007). Depression–anxiety relationships with chronic physical conditions: results from the World Mental Health Surveys. Journal of Affective Disorders 103, 113–120.CrossRefGoogle ScholarPubMed
Shah, BM, Gupchup, GV, Borrego, ME, Raisch, DW, Knapp, KK (2008). Depressive symptoms in patients with type 2 diabetes in the ambulatory care setting: opportunities to improve outcomes in the course of routine care. Journal of American Pharmacy Association (2003) 48, 737–743.CrossRefGoogle ScholarPubMed
Shemesh, E, Yehuda, R, Milo, O, Dinur, I, Rudnick, A, Vered, Z, Cotter, G (2004). Posttraumatic stress, nonadherence, and adverse outcome in survivors of a myocardial infarction. Psychosomatic Medicine 66, 521–526.CrossRefGoogle ScholarPubMed
Solano, JP, Gomes, B, Higginson, IJ (2006). A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. Journal Pain Symptom Management 31, 58–69.CrossRefGoogle ScholarPubMed
Sowden, GL, Huffman, JC (2009). The impact of mental illness on cardiac outcomes: a review for the cardiologist. International Journal of Cardiology 132, 30–37.CrossRefGoogle ScholarPubMed
Surtees, PG, Wainwright, NW, Khaw, KT, Day, NE (2003). Functional health status, chronic medical conditions and disorders of mood. The British Journal of Psychiatry: The Journal of Mental Science 183, 299–303.CrossRefGoogle ScholarPubMed
Surtees, PG, Wainwright, NW, Luben, RN, Wareham, NJ, Bingham, SA, Khaw, KT (2008). Depression and ischemic heart disease mortality: evidence from the EPIC-Norfolk United Kingdom prospective cohort study. American Journal of Psychiatry 165, 515–523.CrossRefGoogle ScholarPubMed
Trockel, M, Burg, M, Jaffe, A, Barbour, K, Taylor, CB (2008). Smoking behavior postmyocardial infarction among ENRICHD trial participants: cognitive behavior therapy intervention for depression and low perceived social support compared with care as usual. Psychosomatic Medicine 70, 875–882.CrossRefGoogle ScholarPubMed
Vargas, RB, Mangione, CM, Asch, S, Keesey, J, Rosen, M, Schonlau, M, Keeler, EB (2007). Can a chronic care model collaborative reduce heart disease risk in patients with diabetes? Journal of General Internal Medicine 22, 215–222.CrossRefGoogle ScholarPubMed
Vera, M, Perez-Pedrogo, C, Huertas, SE, Reyes-Rabanillo, ML, Juarbe, D, Huertas, A, Reyes-Rodriguez, ML, Chaplin, W (2010). Collaborative care for depressed patients with chronic medical conditions: a randomized trial in Puerto Rico. Psychiatric Services 61, 144–150.CrossRefGoogle ScholarPubMed
Wagner, EH (1998). Chronic disease management: what will it take to improve care for chronic illness? Effective Clinical Practice 1, 2–4.Google ScholarPubMed
Wagner, EH, Austin, BT, Von Korff, M (1996). Organizing care for patients with chronic illness. The Milbank Quarterly 74, 511–544.CrossRefGoogle ScholarPubMed
Wagner, EH, Bennett, SM, Austin, BT, Greene, SM, Schaefer, JK, Vonkorff, M (2005). Finding common ground: patient-centeredness and evidence-based chronic illness care. Journal Alternative Complementary Medicine 11(Suppl 1), S7–S15.CrossRefGoogle ScholarPubMed
WHO (2001). World Health Report 2001: Mental Health: New Understanding, New Hope. WHO: Geneva.Google Scholar
Williams, JW Jr., Katon, W, Lin, EH, Noel, PH, Worchel, J, Cornell, J, Harpole, L, Fultz, BA, Hunkeler, E, Mika, VS, Unutzer, J (2004). The effectiveness of depression care management on diabetes-related outcomes in older patients. Annals of Internal Medicine 140, 1015–1024.CrossRefGoogle ScholarPubMed
Yates, WR, Mitchell, J, Rush, AJ, Trivedi, MH, Wisniewski, SR, Warden, D, Hauger, RB, Fava, M, Gaynes, BN, Husain, MM, Bryan, C (2004). Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*D. General Hospital Psychiatry 26, 421–429.CrossRefGoogle Scholar