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Childhood abuse and psychotic experiences – evidence for mediation by adulthood adverse life events

Published online by Cambridge University Press:  09 October 2017

V. Bhavsar ,
J. Boydell ,
P. McGuire ,
V. Harris ,
M. Hotopf ,
S. L. Hatch ,
J. H. MacCabe  and
C. Morgan
V. Bhavsar*
Affiliation:
Department of Psychosis Studies, King's College London, IOPPN, London, UK
J. Boydell
Affiliation:
Cornwall NHS Foundation Trust, Saint Austell, UK
P. McGuire
Affiliation:
Department of Psychosis Studies, King's College London, IOPPN, London, UK
V. Harris
Affiliation:
Department of Primary Health Care Sciences, University of Oxford, Oxford, UK
M. Hotopf
Affiliation:
Department of Psychological Medicine, King's College London, IOPPN and South London and Maudsley NHS Foundation Trust, London SE5 8AZ, UK
S. L. Hatch
Affiliation:
Department of Psychological Medicine, King's College London, IOPPN and South London and Maudsley NHS Foundation Trust, London SE5 8AZ, UK
J. H. MacCabe
Affiliation:
Department of Psychosis Studies, King's College London, IOPPN, London, UK
C. Morgan
Affiliation:
Department of Health Services and Population Research, King's College London, IOPPN, London, UK
*
*Address for correspondence: V. Bhavsar, Department of Psychosis Studies, King's College London, IOPPN, London, UK. (Email: [email protected])
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Abstract

Aims.

We have previously reported an association between childhood abuse and psychotic experiences (PEs) in survey data from South East London. Childhood abuse is related to subsequent adulthood adversity, which could form one pathway to PEs. We aimed to investigate evidence of mediation of the association between childhood abuse and PEs by adverse life events.

Methods.

Data were analysed from the South East London Community Health Study (SELCoH, n = 1698). Estimates of the total effects on PEs of any physical or sexual abuse while growing up were partitioned into direct (i.e. unmediated) and indirect (total and specific) effects, mediated via violent and non-violent life events.

Results.

There was strong statistical evidence for direct (OR 1.58, 95% CI: 1.19–2.1) and indirect (OR 1.51, 95% CI: 1.32–1.72) effects of childhood abuse on PEs after adjustment for potential confounders, indicating partial mediation of this effect via violent and non-violent life events. An estimated 47% of the total effect of abuse on PEs was mediated via adulthood adverse life events, of which violent life events made up 33% and non-violent life events the remaining 14%.

Conclusions.

The association between childhood abuse and PEs is partly mediated through the experience of adverse life events in adulthood. There is some evidence that a larger proportion of this effect was mediated through violent life events than non-violent life events.

Keywords

Child abusepopulation surveypsychosistraumaviolence
Type
Original Articles
Information
Epidemiology and Psychiatric Sciences , Volume 28 , Issue 3 , June 2019 , pp. 300 - 309
Copyright
Copyright © Cambridge University Press 2017 

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