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Zika virus infections in Nigeria: virological and seroepidemiological investigations in Oyo State

Published online by Cambridge University Press:  15 May 2009

A. H. Fagbami
A. H. Fagbami
Affiliation:
Virus Research Laboratory, University of Ibadan, Ibadan, Nigeria
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Summary

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A study of Zika virus infections was carried out in four communities in Oyo State, Nigeria. Virus isolation studies between 1971 and 1975 yielded two virus isolations from human cases of mild febrile illness. Haemagglutination-inhibition tests revealed a high prevalence of antibodies to Zika and three other flaviviruses used. The percentages of positive sera were as follows: Zika (31%), Yellow fever (50%), West Nile (46%), and Wesselsbron (59%). Neutralization tests showed that 40% of Nigerians had Zika virus neutralizing antibody. Fifty per cent of Zika virus immune persons had neutralizing antibody to Zika alone or to Zika and one other flavivirus. A total of 121 sera had antibody to Zika virus; of these 48 (40%) also showed antibody to two other flaviviruses, and 12 (10%) had antibodies to three or more other viruses. The percentage of neutralizing antibodies to other flaviviruses in Zika virus immune sera was 81% to Dengue type 1, 58% to Yellow fever, 7% to Wesselsbron, 6% to West Nile and 3% to Uganda S.

Type
Research Article
Information
Journal of Hygiene , Volume 83 , Issue 2 , October 1979 , pp. 213 - 219
Copyright
Copyright © Cambridge University Press 1979

References

Boorman, J. P. & Draper, C. C. (1968). Isolations of arboviruses in the Lagos area of Nigeria and a survey of antibodies to them in man and animals. Transactions of the Royal Society for Tropical Medicine and Hygiene 62, 269–77.CrossRefGoogle Scholar
Carey, D. E., Kemp, G. E., Troup, J. M., White, H. A., Smith, E. A., Addy, R. F., Fom, A. L., Pifer, J., Jones, E. M., Bres, P. & Shope, R. E. (1972). Epidemiological aspects of the 1969 Yellow fever epidemic in Nigeria. Bulletin of the World Health Organization 46, 645–51.Google ScholarPubMed
Clarke, D. H. & Casals, J. (1958). Technique for haemagglutination inhibition with arthropod-borne viruses. American Journal of Tropical Medicine & Hygiene 7, 561–73.CrossRefGoogle ScholarPubMed
Dick, G. W. A., Kitchen, S. F. & Haddow, A. J. (1952). Zika virus isolation and serological specificity. Transactions of The Royal Society for Tropical Medicine and Hygiene 46, 509–20.CrossRefGoogle ScholarPubMed
Downs, W. G. (1975). Malaria: the great umbrella. Bulletin of the New York Academy of Medical Sciences 51, 984–90.Google ScholarPubMed
Fabiyi, A. & Macnamara, F. N. (1962). The effect of heterologous antibodies on the serological conversion rate after 17D Mouse Brain Yellow Fever Vaccination. American Journal of Tropical Medicine and Hygiene 11, 817–21.CrossRefGoogle Scholar
Fagbami, A. (1977). Epidemiological investigations on arbovirus infcetions at Igbo-Ora, Nigeria. Tropical and Geographical Medicine 29, 187–91.Google Scholar
Fagbami, A. H., Attah, Ed'b., Fabiyi, A. & O'connor, E. H. (1976). Yellow fever outbreak in south eastern State of Nigeria: virological and serological studies. Nigerian Medical Journal 6, 38–41.Google ScholarPubMed
Fagbami, A. H., Monath, T. P. & Fabiyi, A. (1977). Dengue virus infections in Nigeria: a survey for antibodies in monkeys and humans. Transactions of the Royal Society for Tropical Medicine 71, 60–65.CrossRefGoogle ScholarPubMed
Guyer, B. (1972). Serological survey for arboviruses in Igbo-Ora, Western Nigeria. Annals of Tropical Medicine and Parasitology 66, 243–9.CrossRefGoogle ScholarPubMed
Haldane, J. B. S. (1960): ‘Dex’ or Order of magnitude? Nature 187, 879.CrossRefGoogle Scholar
Henderson, B. E., Cheshire, P. P., Kirya, G. B. & Lule, M., (1970). Immunologic studies with yellow fever and selected African Group B arboviruses in Rhesus and vervet monkeys. American Journal of Tropical Medicine and Hygiene 19, 110–18.CrossRefGoogle ScholarPubMed
Lee, V. H. (1969). Studies of arthropod hosts: Virus isolations. Report of Virus Research Laboratory, University of Ibadan, Nigeria, p. 100.Google Scholar
Macnamara, F. N., Horn, B. W. & Porterfield, J. S. (1959). Yellow fever and other arthropod-borne viruses. A consideration of two serological surveys made in South-Western Nigeria. Transactions of the Royal Society for Tropical Medicine and Hygeine 53, 202–12.CrossRefGoogle ScholarPubMed
Marchette, N. J., Garcia, R. & Rudnick, A. (1969). Isolation of Zika virus from Aedes aegypti mosquitoes in Malaysia. American Journal of Tropical Medicine and Hygeine 18, 411–15.CrossRefGoogle ScholarPubMed
Moore, D. L., Causey, O. R., Carey, D. E., Reddy, S., Cooke, A. R., Akinkugbe, F. M., David-West, T. S. & Kemp, G. E. (1975). Arthropod-borne virus infections of man in Nigeria 1964–1970. Annals of Tropical Medicine and Parasitology 69, 49–64.CrossRefGoogle ScholarPubMed
Monath, T. P., Wilson, D. C., Stroh, G., Lee, V. H. & Smith, E. A. (1973). The 1970 yellow fever epidemic in Okwoga District Benue Plateau State of Nigeria. II: Immunity survey to determine geographic limit and origins of epidemic. Bulletin of the World Health Organization 48, 123–8.Google Scholar
Monath, T. P., Lee, V. H., Fagbami, A., Tomori, O. & Wilson, D. (1974). Arbovirus studies in Nupeko forest, a possible natural focus of yellow fever virus in Nigeria. I: Description of the area and a serological survey. Transactions of the Royal Society for Tropical Medicine and Hygiene 68, 30–38.CrossRefGoogle Scholar
Reed, L. J. & Muench, H. (1938). A simple method for estimating fifty percent endpoints. American Journal of Tropical Medicine and Hygiene 27, 493–7.Google Scholar
Simpson, D. I. H. (1964). Zika virus infection in man. Transactions of the Royal Society for Tropical Medicine and Hygiene 58, 335–8.CrossRefGoogle ScholarPubMed
Smithburn, K. C. (1952). Neutralizing antibodies against certain recently isolated viruses in sera of human beings residing in East Africa. Journal of Immunology 69, 223–34.CrossRefGoogle ScholarPubMed
Southam, C. M. (1956). Serologic studies of encephalitis in Japan. Haemagglutination inhibition, complement fixing and neutralizing antibody following overt Japanese B encephalitis. Journal of Infectious Diseases 99, 155–62.CrossRefGoogle ScholarPubMed
Weinbren, M. P. (1958). An improved method for the complement fixation test using small quantities of reagents. Report of East African Research Institute 8, 38.Google Scholar
Weinbren, M. P. & Williams, M. C. (1958). Zika virus; further isolations in Zika area and some studies on the strains isolated. Transactions of the Royal Society for Tropical Medicine and Hygiene 52, 263–5.CrossRefGoogle ScholarPubMed