Within- and between-pen transmission of Classical Swine Fever Virus: a new method to estimate the basic reproduction ratio from transmission experiments

D. KLINKENBERG; J. DE BREE; H. LAEVENS; M. C. M. DE JONG

doi:10.1017/S0950268801006537

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We present a method to estimate basic reproduction ratio R0 from transmission experiments. By using previously published data of experiments with Classical Swine Fever Virus more extensively, we obtained smaller confidence intervals than the martingale method used in the original papers. Moreover, our method allows simultaneous estimation of a reproduction ratio within pens R0w and a modified reproduction ratio between pens R′0b. Resulting estimates of R0w and R′0b for weaner pigs were 100 (95% CI 54·4–186) and 7·77 (4·68–12·9), respectively. For slaughter pigs they were 15·5 (6·20–38·7) and 3·39 (1·54–7·45), respectively. We believe, because of the smaller confidence intervals we were able to obtain, that the method presented here is better suited for use in future experiments.

Crossref Citations

This article has been cited by the following publications. This list is generated based on data provided by Crossref.

Alexandersen, S. Quan, M. Murphy, C. Knight, J. and Zhang, Z. 2003. Studies of Quantitative Parameters of Virus Excretion and Transmission in Pigs and Cattle Experimentally Infected with Foot-and-Mouth Disease Virus. Journal of Comparative Pathology, Vol. 129, Issue. 4, p. 268.

Paton, D.J and Greiser-Wilke, I 2003. Classical swine fever – an update. Research in Veterinary Science, Vol. 75, Issue. 3, p. 169.

Klinkenberg, D. Everts-van der Wind, A. Graat, E.A.M. and de Jong, M.C.M. 2003. Quantification of the effect of control strategies on classical swine fever epidemics. Mathematical Biosciences, Vol. 186, Issue. 2, p. 145.

Ribbens, S. Dewulf, J. Koenen, F. Laevens, H. and de Kruif, A. 2004. Transmission of classical swine fever. A review. Veterinary Quarterly, Vol. 26, Issue. 4, p. 146.

Eblé, Phaedra L Bouma, A de Bruin, M.G.M van Hemert-Kluitenberg, F van Oirschot, J.T and Dekker, A 2004. Vaccination of pigs two weeks before infection significantly reduces transmission of foot-and-mouth disease virus. Vaccine, Vol. 22, Issue. 11-12, p. 1372.

Feberwee, A. Mekkes, D. R. Klinkenberg, D. Vernooij, J. C. M. Gielkens, A. L. J. and Stegeman, J. A. 2005. An experimental model to quantify horizontal transmission ofMycoplasma gallisepticum. Avian Pathology, Vol. 34, Issue. 4, p. 355.

Busani, Luca Pozza, Manuela Dalla Bonfanti, Lebana Toson, Marica Ferrè, Nicola and Marangon, Stefano 2007. Intervention Strategies for Low-Pathogenic Avian Influenza Control in Italy. Avian Diseases, Vol. 51, Issue. s1, p. 470.

Höhle, Michael and Feldmann, Ulrike 2007. RLadyBug—An R package for stochastic epidemic models. Computational Statistics & Data Analysis, Vol. 52, Issue. 2, p. 680.

Velthuis, A.G.J. De Jong, M.C.M. and De Bree, J. 2007. Comparing methods to quantify experimental transmission of infectious agents. Mathematical Biosciences, Vol. 210, Issue. 1, p. 157.

Orsel, K. de Jong, M.C.M. Bouma, A. Stegeman, J.A. and Dekker, A. 2007. Foot and mouth disease virus transmission among vaccinated pigs after exposure to virus shedding pigs. Vaccine, Vol. 25, Issue. 34, p. 6381.

Tiensin, Thanawat Nielen, Mirjam Vernooij, Hans Songserm, Thaweesak Kalpravidh, Wantanee Chotiprasatintara, Sirikan Chaisingh, Arunee Wongkasemjit, Surapong Chanachai, Karoon Thanapongtham, Weerapong Srisuvan, Thinnarat and Stegeman, Arjan 2007. Transmission of the Highly Pathogenic Avian Influenza Virus H5N1 within Flocks during the 2004 Epidemic in Thailand. The Journal of Infectious Diseases, Vol. 196, Issue. 11, p. 1679.

Orsel, K. Dekker, A. Bouma, A. Stegeman, J.A. and de Jong, M.C.M. 2007. Quantification of foot and mouth disease virus excretion and transmission within groups of lambs with and without vaccination. Vaccine, Vol. 25, Issue. 14, p. 2673.

Bouwknegt, Martijn Frankena, Klaas Rutjes, Saskia A. Wellenberg, Gerard J. de Roda Husman, Ana Maria van der Poel, Wim H.M. and de Jong, Mart C.M. 2008. Estimation of hepatitis E virus transmission among pigs due to contact-exposure. Veterinary Research, Vol. 39, Issue. 5, p. 40.

Lurette, A. Belloc, C. Touzeau, S. Hoch, T. Seegers, H. and Fourichon, C. 2008. Modelling batch farrowing management within a farrow-to-finish pig herd: influence of management on contact structure and pig delivery to the slaughterhouse. Animal, Vol. 2, Issue. 1, p. 105.

Eblé, P.L. de Koeijer, A.A. de Jong, M.C.M. Engel, B. and Dekker, A. 2008. A meta-analysis quantifying transmission parameters of FMDV strain O Taiwan among non-vaccinated and vaccinated pigs. Preventive Veterinary Medicine, Vol. 83, Issue. 1, p. 98.

Andraud, Mathieu Grasland, Béatrice Durand, Benoît Cariolet, Roland Jestin, André Madec, François and Rose, Nicolas 2008. Quantification of porcine circovirus type 2 (PCV-2) within- and between-pen transmission in pigs. Veterinary Research, Vol. 39, Issue. 5, p. 43.

Weesendorp, Eefke Backer, Jantien Stegeman, Arjan and Loeffen, Willie 2009. Effect of strain and inoculation dose of classical swine fever virus on within-pen transmission. Veterinary Research, Vol. 40, Issue. 6, p. 59.

Orsel, K. Bouma, A. Dekker, A. Stegeman, J.A. and de Jong, M.C.M. 2009. Foot and mouth disease virus transmission during the incubation period of the disease in piglets, lambs, calves, and dairy cows. Preventive Veterinary Medicine, Vol. 88, Issue. 2, p. 158.

2009. Control and eradication of Classic Swine Fever in wild boar. EFSA Journal, Vol. 7, Issue. 1, p. 932.

Durand, Benoit Davila, Sylvie Cariolet, Roland Mesplède, Alain and Le Potier, Marie-Frédérique 2009. Comparison of viraemia- and clinical-based estimates of within- and between-pen transmission of classical swine fever virus from three transmission experiments. Veterinary Microbiology, Vol. 135, Issue. 3-4, p. 196.

Download full list

Article contents

Within- and between-pen transmission of Classical Swine Fever Virus: a new method to estimate the basic reproduction ratio from transmission experiments

Abstract

Save article to Kindle

Save article to Dropbox

Save article to Google Drive

Reply to: Submit a response

Your details

You have entered the maximum number of contributors

Conflicting interests