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Virulence and Immunogenic Activities of B. Typhosus in Relation to its Antigenic Constituents

Published online by Cambridge University Press:  15 May 2009

A. Felix  and
R. M. Pitt
A. Felix
Affiliation:
From the Bacteriological Department. Lister Institute, London
R. M. Pitt
Affiliation:
From the Bacteriological Department. Lister Institute, London
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1. Rough variants, derived from strains of B. typhosus which possess the Vi antigen, may still contain this antigen though the smooth O antigen has been lost.

2. Such variants, which are non-virulent, are yet capable of inducing active and passive immunity.

3. The virulence of B. typhosus depends on the combined activity of the smooth O and the Vi antigen. Nevertheless the Vi antibody alone is sufficient to protect against infection with strains of the highly virulent type.

4. The use of avirulent, rough, but Vi-containing variants as vaccines and in the preparation of therapeutic sera is discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 35 , Issue 3 , August 1935 , pp. 428 - 436
Copyright
Copyright © Cambridge University Press 1935

References

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