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The Vi antigen of Salmonella paratyphi A

Published online by Cambridge University Press:  15 May 2009

A. Felix
A. Felix
Affiliation:
From the Central Enteric Reference Laboratory and Bureau, Public Health Laboratory Service (Medical Research Council), London
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1. Salmonella paratyphi A possesses a specific Vi antigen essentially similar to that of the Vi antigen of Salm. typhi.

2. O-insensitive strains of Salm. paratyphi A contain more Vi antigen, and are more virulent for mice, than O-sensitive strains.

3. The most suitable strains for the preparation of paratyphoid-A vaccine are those that develop both the Vi and the O antigens in maximum quantities. The methods of selecting the vaccine strain of Salm. paratyphi A and routinely examining the cultures are essentially the same as those applied to the virulent Vi+O form of Salm. typhi.

4. Pure A Vi antiserum is destined to assume importance in the identification of Salm. paratyphi A strains.

5. Kauffmann's erroneous conclusion that Salm. paratyphi A does not develop Vi antigen is critically reviewed.

Type
Research Article
Information
Journal of Hygiene , Volume 50 , Issue 4 , December 1952 , pp. 540 - 549
Copyright
Copyright © Cambridge University Press 1952

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