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Vaccination against rubella of susceptible schoolgirls in Reading

Published online by Cambridge University Press:  15 May 2009

D. F. Rowlands
Affiliation:
Department of Health Services, County Borough of Reading
D. S. Freestone
Affiliation:
Department of Clinical Immunology, The Wellcome Research Laboratories, Beckenham, Kent
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Summary

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This study of 724 13-year-old schoolgirls in the County Borough of Reading showed that approximately 25% were susceptible to rubella. 96·1% of the 129 seronegative girls and significant numbers of girls with low rubella HAI antibody titres responded to subcutaneous vaccination with Wistar RA. 27/3 rubella vaccine. The incidence of most reactions after vaccination was similar in those who responded to vaccine and those who were initially immune but did not develop rising antibody titres, but rash, lymphadenopathy and headache occurred significantly more frequently in the susceptible group.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Cooper, L. Z. & Krugman, S. (1966). Diagnosis and management: congenital rubella. Pediatrics, Springfield 37, 335.CrossRefGoogle ScholarPubMed
Draper, C. C. & Kelly, A. (1969). Experience with the use of blood collected on discs of absorbent paper for measuring rubella HAI antibodies. International Symposium on Rubella Vaccines, London, 1968. Symposium Series on Immunobiological Standards 11, 105. Basel & New York: Karger.Google Scholar
Dudgeon, J. A. (1969). Rubella vaccines. British Medical Bulletin 25, 159.CrossRefGoogle ScholarPubMed
Dudgeon, J. A., Marshall, W. C., Peckham, C. S. & Hawkins, G. T. (1969). Clinical and laboratory studies with rubella vaccines in adults. British Medical Journal. i, 271.CrossRefGoogle Scholar
Godber, G. E. (1970). Department of Health and Social Security Circular CMO, 9/70; 29 July.Google Scholar
Horstmann, D. M., Liebhaber, H., Le Bouvier, G. L., Rosenberg, D. A. & Halstead, S. B. (1970). Rubella: reinfection of vaccinated and naturally immune persons exposed in an epidemic. New England Journal of Medicine 283, 771.CrossRefGoogle Scholar
Meyer, H. M., Parkman, P. D., Hobbins, T. E., Larson, H. E., Davis, W. J., Simsarian, J. P. & Hopps, H. E. (1969). Attenuated rubella viruses: laboratory and clinical characteristics. American Journal of Diseases of Children 118, 155.CrossRefGoogle ScholarPubMed
Rowlands, D. F. & Gatherer, A. (1970). A survey of the immunological status to rubella of 15-year old girls in Reading. Medical Officer 123, 205.Google Scholar
Wilkins, J., Leedom, J. M., Portnoy, B. & Salvatore, M. A. (1969). Reinfection with rubella virus despite live vaccine induced immunity. American Journal of Diseases of Children 118, 275.CrossRefGoogle ScholarPubMed