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The use of acetylethyleneimine in the production of inactivated foot-and-mouth disease vaccines

Published online by Cambridge University Press:  15 May 2009

F. Brown ,
N. St G. Hyslop ,
Joan Crick  and
A. W. Morrow
F. Brown
Affiliation:
Research Institute (Animal Virus Diseases), Pirbright, Surrey
N. St G. Hyslop
Affiliation:
Research Institute (Animal Virus Diseases), Pirbright, Surrey
Joan Crick
Affiliation:
Research Institute (Animal Virus Diseases), Pirbright, Surrey
A. W. Morrow
Affiliation:
Research Institute (Animal Virus Diseases), Pirbright, Surrey
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Suspensions of FMD virus treated with 0·05% formalin at 26° C. for periods up to 144 hr. remained infective for cattle, although the infectivity could not be detected in the presence of aluminium hydroxide. Infectivity was detected in similar virus suspensions which had been treated with 0·05% AEI at 37° C. for 8 hr. but not in suspensions treated for 12 hr.

Vaccines prepared from these suspensions were antigenically potent and serum neutralization tests demonstrated the development and regression of serum antibody. The AEI vaccines were at least as potent as the corresponding formalin vaccines.

Type
Research Article
Information
Journal of Hygiene , Volume 61 , Issue 3 , September 1963 , pp. 337 - 344
Copyright
Copyright © Cambridge University Press 1963

References

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