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Trials of intranasally administered rubella vaccine

Published online by Cambridge University Press:  15 May 2009

Irene B. Hillary
Irene B. Hillary
Affiliation:
Department of Medical Microbiology, University College, Dublin
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Summary

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No evidence of vaccine virus transmission was found in two studies where Wistar RA 27/3 rubella vaccine was administered intranasally. Vaccine was immunogenic in all of 23 vaccinated children in one study, while in the other only 5 of the 11 vaccinees developed antibody. The reduced seroconversion rate in the latter study appears to have been caused by one or a combination of factors, including the vaccination technique, the presence of infective nasal conditions in vaccinees and the titre of vaccine used.

Type
Research Article
Information
Journal of Hygiene , Volume 69 , Issue 4 , December 1971 , pp. 547 - 552
Copyright
Copyright © Cambridge University Press 1971

References

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