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Transplacental transfer of measles and total IgG

Published online by Cambridge University Press:  01 April 1999

G. GONÇALVES ,
F. T. CUTTS ,
M. HILLS ,
H. REBELO-ANDRADE ,
F. A. TRIGO  and
H. BARROS
G. GONÇALVES
Affiliation:
Instituto Nacional de Saúde Dr Ricardo Jorge, Delegação no Porto, Largo 1° de Dezembro, 4000–404 Porto Codex, Portugal Serviço de Higiene e Epidemiologia da Faculdade de Medicina do Porto, Alameda Prof. Hernâni Monteiro, 4200 Porto, Portugal
F. T. CUTTS
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
M. HILLS
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
H. REBELO-ANDRADE
Affiliation:
Instituto Nacional de Saúde Dr Ricardo Jorge, Centro Nacional da Gripe, Av. Padre Cruz, 1699 Lisboa Codex, Portugal
F. A. TRIGO
Affiliation:
Laboratório de Imunologia, Faculdade de Medicina do Porto, Alameda Prof. Hernâni Monteiro, 4200 Porto, Portugal
H. BARROS
Affiliation:
Serviço de Higiene e Epidemiologia da Faculdade de Medicina do Porto, Alameda Prof. Hernâni Monteiro, 4200 Porto, Portugal
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Abstract

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This study was conducted to evaluate factors affecting the levels of total IgG (tIgG) and measles specific IgG (mIgG) in mother and cord sera, and the efficiency of transplacental transport of tIgG and mIgG. The study was conducted in four hospitals in Oporto, Portugal, where 1539 women and their newborns were enrolled. Measles IgG levels were lower among vaccinated mothers and respective cord sera than among vaccinated counterparts. Cord mIgG was strongly correlated with maternal levels in both vaccinated and unvaccinated groups. Transplacental transport efficiency (TTE) of mIgG decreased with increasing maternal levels, although almost one third of the observed effect was due to measurement error. The TTE was not affected by vaccination status. Monitoring maternal measles antibody levels and maternal vaccination status could be useful to determine when the age for measles vaccination can be reduced.

Type
Research Article
Information
Epidemiology & Infection , Volume 122 , Issue 2 , April 1999 , pp. 273 - 279
Copyright
© 1999 Cambridge University Press