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The toxicity of chlorophacinone and warfarin to house mice (Mus musculus)

Published online by Cambridge University Press:  15 May 2009

Mogens Lund
Affiliation:
Statens Skadedyrlaboratorium, Skovbrynet 14, DK-2800, Lyngby, Denmark
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Summary

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Individually caged house mice (Mus m. musculus) were fed 0·025% warfarin (3(2-acetyl-l-phenylethyl)-4-hydroxycoumarin) or 0·025% chlorophacinone (2-(l-(p-chlorophenyl)-l-phenyl) acetyl-l,3-indandione) for periods varying from 1 to 21 days. In all, 320 mice, 160 of each sex, were tested.

A significant difference was found between the mortalities obtained by the two compounds. In feeding periods varying from 1–5 days chlorophacinone produced a mortality of 60–85 % and warfarin only 5–75 %. Five per cent, however, did survive 21 days feeding on each compound.

A great variation in the susceptibility of individual mice was established for chlorophacinone as well as for warfarin.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1971

References

REFERENCES

Annual Report, Government Pest Infestation Laboratory, Denmark (19611962), pp. 72–3; (1963), pp. 73–5.Google Scholar
Bentley, E. W. & Larthe, Y. (1959). The comparative rodenticidal efficiency of five anti-coagulants. Journal of Hygiene 57, 135–49.CrossRefGoogle ScholarPubMed
Litchfield, J. T. & Wilcoxon, F. (1949). A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96, 99113.Google ScholarPubMed
Rowe, F. P. & Redfern, R. (1964). The toxicity of 0·025% warfarin to wild house mice (Mus musculus L.). Journal of Hygiene, 62, 389–93.CrossRefGoogle ScholarPubMed
Rows, F. P. & Redfern, R. (1965). Toxicity tests on suspected warfarin-resistant house mice (Mus musculus L.). Journal of Hygiene 63, 417–25.Google Scholar
Rowe, F. P. & Redfern, R. (1968). Laboratory studies on the toxicity of anti-coagulant rodenticides to wild house mice (Mus musculus L.). Annals of Applied Biology 61, 303–49.Google ScholarPubMed
Technical Report on Chlorophacinone (1965). Lyon: Lipha.Google Scholar