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The titration of vaccinia virus by the pock counting technique

Published online by Cambridge University Press:  15 May 2009

C. Kaplan  and
G. Belyavin
C. Kaplan
Affiliation:
The Lister Institute of Preventive Medicine, Elstree, Hertfordshire
G. Belyavin
Affiliation:
Department of Bacteriology, University College Hospital Medical School, London, W.C. 1
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Ninety-seven groups of five-membrane pock counts from 115 titrations of vaccinia virus preparations were examined in an attempt to identify the statistical distribution followed by such counts, and to obtain an estimate of the overall coefficient of variation of the technique.

It was found that the distribution of counts was neither Poissonian nor normal, and that the count variances ‘wandered’ so extensively that no valid estimate of the overall coefficient of variation was possible. Nor was it possible to assess the intrinsic reproducibility of the test, although it is empirically a useful one.

Type
Research Article
Information
Journal of Hygiene , Volume 55 , Issue 4 , December 1957 , pp. 494 - 501
Copyright
Copyright © Cambridge University Press 1957

References

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