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Susceptibility of enterococci and epidemiology of enterococcal infections in the 1980s

Published online by Cambridge University Press:  15 May 2009

R. C. George  and
A. H. C. Uttley
R. C. George
Affiliation:
Antibiotic Reference Laboratory, Division of Hospital Infection, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT
A. H. C. Uttley
Affiliation:
Public Health Laboratory, Dulwich Hospital, East Dulwich Grove, London SE22 8QS
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Enterococcisensu stricto form part of the normal gut flora (1) and may be found in the mouth, vagina and anterior urethra (2). They are opportunist pathogens which can cause serious infection including endocarditis. Nosocomial enterococcal infection appears to be increasing both in the UK (Public Health Laboratory Service [PHLS] Communicable Disease Surveillance Centre [CDSC], unpublished) and the USA (3) and to correspond to usage of broad spectrum β-lactam antimicrobial agents (4−7) and invasive surgical devices (8, 9). At the same time, the incidence of enterococci resistant or tolerant to previously commonly employed antimicrobial agents or their synergistic combinations is increasing and is compromising therapy of serious enterococcal infection. Strains of enterococci with high-level resistance to streptomycin and kanamycin (minimal inhibitory concentrations [MICs] > 2000 mg/L) were first reported in 1970 (10, 11) and rapidly became widespread (8, 12−14).

Type
Special Article
Information
Epidemiology & Infection , Volume 103 , Issue 3 , December 1989 , pp. 403 - 413
Copyright
Copyright © Cambridge University Press 1989

References

REFERENCES

1.Noble, CJ.Carriage of group D streptococci in the human bowel. J Clin Pathol 1978; 3: 1182–6.CrossRefGoogle Scholar
2.Mandell, GL, Kaye, D, Levison, ME et al. , Enterococcal endocarditis: An analysis of 38 patients observed at the New York Hospital – Cornell Medical Center. Arch Intern Med. 1970; 125: 258–64.CrossRefGoogle ScholarPubMed
3.Horan, TC, White, JW, Jarvis, WR et al. , Nosocomial infection surveillance. 1984. Morbid Mortal Wkly Rep. CDC Surveillance Summaries 1986; 35: 17SS–29SS.Google Scholar
4.Morrison, AJ, Wenzel, RP.Nosocomial urinary tract infections due to enterococcus: ten years experience at a university hospital. Arch Intern Med 1986; 146: 1549–1951.CrossRefGoogle ScholarPubMed
5.Hoffman, SA, Moellering, RC JrThe enterococcus: “putting the bug in our ear ”. Ann Intern Med 1987; 106: 757–61.CrossRefGoogle Scholar
6.Lemoine, L, Hunter, PR.Enterococcal urinary tract infections in a teaching hospital. Eur J Clin Microbiol 1987; 6: 574–576.CrossRefGoogle ScholarPubMed
7.Zervos, MJ, Kauffman, CA, Therasse, PA. Bergman, AG. Mikesell, TS. Schaberg, DR.Nosocomial infection by gentamicin-resistant Streptococcus faecalis, an epidemiologic study. Ann Intern Med 1987; 106: 687–91.CrossRefGoogle ScholarPubMed
8.Zervos, MJ, Dembinski, S, Mikesell, TS, Schaberg, DR.High-level resistance to gentamicin in Streptococcus faecalis: risk factors and evidence for exogenous acquisition of infection. J Infect Dis 1986; 153: 1075–83.CrossRefGoogle ScholarPubMed
9.Warren, REDifficult streptococci. J Hosp Infect 1988; 11 Suppl A352–7.CrossRefGoogle ScholarPubMed
10.Standiford, HC. DeMaine, JB. Kirby, WMM.Antibiotic synergism of enterococci: relation to inhibitory concentration. Arch Intern Med 1970; 126: 255–9.CrossRefGoogle Scholar
11.Moellering, RC Jr,Wennersten, CBGMedrekt, T, Weinberg, AN, Prevalence of high-level resistance to aminoglyeosides in clinical isolates of enterococci. Antimicrob Ag Chemother 1970; pp 335–40.Google ScholarPubMed
12.Ruhen, RW. Darrell, JH.Antibiotic synergism against Group D streptococci in the treatment of endocarditis. Med J Aust 1973; 2: 114–6.CrossRefGoogle Scholar
13.Calderwood, SA, Wennersten, C. Moellering, RC Jr. Kunz, LJ. Krogstad, DJ. Resistance to six aminoglycosidic aminocyclitol antibiotics among enterococci: prevalence, evolution and relationship to synergism with penicillin. Antimicrob Ag Chemother 1977; 12: 401–5.CrossRefGoogle ScholarPubMed
14.Smyth, EG, Stevens, PJ, Holliman, RE.Prevalence and susceptibility of highly gentamicin resistant Enterococcus faecalis in a South London teaching hospital. J Antimicrob Chemother 1989; 23: 633–9.CrossRefGoogle Scholar
15.Horodniceanu, T, Bougueleret, L, El-Solh, N.Bieth, G, Delbos, F.High-level, plasmid-borne resistance to gentamicin in Streptococcus faecalis subsp. zymogenes. Antimicrob Ag Chemother 1979; 16: 686–9.CrossRefGoogle ScholarPubMed
16.Kono, M, Hamashima, H, O'Hara, K.Modification of aminoglycoside antibiotics by clinical isolates of Streptococcus faecalis. J Antibiotics 1981: 34: 222–30.CrossRefGoogle ScholarPubMed
17.Mederski-Samoraj, BD, Murray, BE.High-level resistance to gentamicin in clinical isolates of enterocoeci. J Infect Dis 1983; 147: 751–7.CrossRefGoogle Scholar
18.Murray, BE, Tsao, J, Panida, J.Enterococci from Bangkok. Thailand. with high-level resistance to currently available aminoglycosides. Antimicrob Ag Chemother 1983; 23: 799–802.CrossRefGoogle ScholarPubMed
19.Chen, HY, Williams, JD.Transferable resistance and aminoglycoside-modifying enzymes in enterocoeci. J Med Microbiol 1985; 20: 187–96.CrossRefGoogle Scholar
20.Namchamkin, I, Axelrod, P. Talbot, GH et al. , Multiply high-level-aminoglycoside-resistant enterococci isolated from patients in a university hospital. J Clin Microbiol 1988; 26: 1287–91.CrossRefGoogle Scholar
21.Patterson, JE, Masecar, BL, Kauffman, CA, Schaberg, DR, Hierholzer, WJ JrZervos, MJ.Gentamicin resistance plasmids of enterococci from diverse geographic areas are heterogeneous. J Infect Dis 1988; 158: 212–6.CrossRefGoogle ScholarPubMed
22.Uttley, AHC, Collins, CH, Naidoo, J, George, RC, Vancomycin-resistant enterococci. Lancet 1988; i: 57–8.CrossRefGoogle Scholar
23.Thong, ML.Faoagali, JL.Allworth, AM. High level aminoglycoside resistant streptococci in a large public hospital in Australia. In: Abstracts of the 4th Eur Cong Clin Microbiol. Nice. 1989; 409.Google Scholar
24.Murray, BE, Mederski-Samoraj, BD.Transferable β-lactamase: a new mechanism for in ritro penicillin resistance in Streptococcus faecalis. J Clin Invest 1983; 72: 1168–1671.CrossRefGoogle Scholar
25.Patterson, JE, Masecar, BL, Zervos, MJ.Characterization and comparison of two penicillinase producing strains of Streptococcus (Enterococcus) faecalis. Antimicrob Ag Chemother 1988; 32: 122–4.CrossRefGoogle ScholarPubMed
26.Fontana, R, Grossato, A, Rossi, L, Cheng, YR, Satta, G.Transition from resistance to hypersusceptibility to β -lactam antibiotics associated with loss of a low-affinity penicillin- binding protein in a Streptococcus faecium mutant highly resistant to penicillin. Antimicrob Ag Chemother 1985; 28: 678–83.CrossRefGoogle Scholar
27.Williamson, R, Le Bouguenec, C, Gutmann, L, Horaud, T.One or two low affinity penicillin- binding proteins may he responsible for the range of susceptibility of Enterococcus faecium to benzylpenicillin. J Gen Microbiol 1985; 131: 1933–1940.Google ScholarPubMed
28.Chen, HY.Williams, JD.Penicillin-binding proteins in Streptococcus faecalis and S. faecium. J Med Microbiol 1987; 23: 141–7.CrossRefGoogle ScholarPubMed
29.Leclercq, R. Derlot, E, Duval, J, Courvalin, P.Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N Engl J Med 1988; 319: 157–61.CrossRefGoogle ScholarPubMed
30.Lutticken, R, Kunstmann, G.Vancomycin-resistant Streptococcaceae from clinical material. Zbl Bakt Hyg 1988; A267: 379–82.Google ScholarPubMed
31.Alonso, T, Linares, J, Martin, R, Lopez, P, Garcia, D, Escribano, E. Antibiotic resistance in Enterococcus faecalis. In: Abstracts of the 4th Eur Cong Clin Microbiol, Nice, 1989; 175.Google Scholar
32.Leclercq, R.Derlot, E, Weber, M, Duval, J, Courvalin, P.Transferable vancomycin and teicoplanin resistance in Enterococcus faecium. Antimicrob Ag Chemother 1989; 33: 10–15.CrossRefGoogle ScholarPubMed
33.Reguera, JA, Perez-Diaz, JC, Martinez-Ferrer, M, Baquero, F Conjugative vancomycin resistance in Enterococcus faecium and Enterococcus faecalis. In: Abstracts of the 4th Eur Cong Clin Microbiol Nice 1989; 275.Google Scholar
34.Shlaes, DM, Al-Obeid, S, Shlaes, JH, Boisivon, A, Williamson, R., Inducible, transferable resistance to vancomycin in Enterococcus faecium D399. J Antimicrob Chemother 1989; 23: 503–8.CrossRefGoogle ScholarPubMed
35.Shlaes, DM, Bouvet, A, Devine, C, Shlaes, JH, Al-Obeid, A, Williamson, R, Inducible, transferable resistance to vancomycin in Enterococcus faecalis A256 Antimicrob Ag Chemother 1989; 33: 198–203.CrossRefGoogle ScholarPubMed
36.Uttley, AHC, George, RC, Naidoo, J et al. , High-level vancomycin-resistant enterococci causing hospital infections. Epidem Inf 1989; 103: 173–81.CrossRefGoogle ScholarPubMed
37.Kim, KS.Bayer, AS.Significance of in-vitro penicillin tolerance in experimental enterococcal endocarditis. J Antimicrob Chemother 1987; 19: 475–85.CrossRefGoogle ScholarPubMed
38.Scheld, WM.Therapy of streptococcal endocarditis: correlation of animal model and clinical studies. J Antimicrob Chemother 1987; 26: Suppl A: 71–85.CrossRefGoogle Scholar
39.Jones, RN, Thornsberry, C.Gram-positive superinfections: a consequence of modern β- lactam chemotherapy. Antimicrob Newsletter 1985; 2: 17–23.CrossRefGoogle Scholar
40.Gullberg, RM, Homann, SR, Phair, JP.Enterococcal bacteraemia: analysis of 75 episodes. Rev Infect Dis 1989; 11: 74–8.CrossRefGoogle ScholarPubMed
41.Kaye, D.Enterococci, Biologic and epidemiologic characteristics and in vitro susceptibility. Arch Intern Med 1982; 142: 2006–9.CrossRefGoogle ScholarPubMed
42.Toala, P, McDonald, A. Wilcox, C. Finland, M.Susceptibility of group D streptococcus (enterococcus) to 21 antibiotics in vitro, with special reference to species differences. Am J Med Sc. 1969; 258: 416–30.CrossRefGoogle Scholar
43.Chen, HY.Resistance of enterococci to antibiotic combinations. J Antimicrob Chemother 1986; 18: 1–8.CrossRefGoogle ScholarPubMed
44.Fu, KP, Neu, HCPiperacillin. a new penicillin active against man bacteria resistant to other penicillins. Antimicrob Ag Chemother 1978; 13: 358–67.CrossRefGoogle Scholar
45.Etienne, J, Gruer, LD. Fleurette, J.Antibiotic susceptibility of strains associated with infective endocarditis. Eur Heart J 1984; 5 Suppl C: 33–7.CrossRefGoogle ScholarPubMed
46.Mortensen, JE, LaRocco, MT.Susceptibility testing of group D streptococci. Clin Microbiol Newsletter 1986; 8: 17–20.CrossRefGoogle Scholar
47.Ingerman, M, Pitsakis, PG, Rosenberg, A et al. , β -lactamase production in experimental endocarditis due to aminoglycoside-resistant Streptococcus faecalis. J Infect Dis 1987; 155: 1226–32.CrossRefGoogle ScholarPubMed
48.Patterson, JE, Colodny, SM, Zervos, MJ.Serious infection due to β-lactamase producing Streptococcus foecalis with high-level resistance to gentamicin. J Infect Dis 1988; 158: 1144–5.CrossRefGoogle Scholar
49.Hindes, RG, Willey, SH, Eliopoulos, GM et al. , Treatment of experimental endocarditis caused by a β-lactamase-producing strain of Enterococcus faecalis with high-level resistance to gentamicin. Antimicrob Ag Chemother 1989; 33: 1019–22.CrossRefGoogle ScholarPubMed
50.Tofte, RW, Solliday, J, Crossley, KB.Susceptibility of enterococci to twelve antibiotics. Antimicrob Ag Chemother 1984; 25: 532–3.CrossRefGoogle ScholarPubMed
51.Murray, BE, Mederski-Samoraj, B, Foster, SK, Brunton, JL, Harford, P.In vitro studies of plasmid-mediated penicillinase from Streptococcus faecalis suggests a staphylococcal origin. J Clin Invest 1986; 77: 289–93.CrossRefGoogle ScholarPubMed
52.Goldstein, EJC, Citron, DM.Comparative in vitro inhibitory activity of cefpirome. ceftazidime and cefotaxime against Pseudomonas aeruginosa. enterococci. Staphylococcus epidermidis, and methicillin-susceptible and -resistant and tolerant and non-tolerant Staphylococcus aureus. Antimicrob Ag Chemother 1985; 28: 160–2.CrossRefGoogle Scholar
53.Sahm, DF, Baker, CN, Jones, RN, Thornsberry, C.Medium-dependent zone size discrepancies associated with susceptibility testing of Group D streptococci agaainst various cephalosporins. J Clin Microbiol 1983; 18: 858–65.CrossRefGoogle Scholar
54.Krogstad, DJ, Moellering, RC Jr Antimicrobial combinations. In: Lorian, V. ed. Antibiotics in laboratory medicine. 2nd ed.Williams & Wilkins. 1986; 537–95.Google Scholar
55.Eliopoulos, GM, Moellering, RC JrSusceptibility of enterococci and Listeria monocytogenes to N-formimidoyl thienamycin alone and in combination with an aminoglycoside. Antimicrob Ag Chemother 1981; 19: 789–93.CrossRefGoogle ScholarPubMed
56.Krogstad, DJ, Parquette, AR.Defective killing of enterococci: a common property of antimicrobial agents acting on the cell wall. Antimicrob Ag Chemother 1980; 17: 965–8.CrossRefGoogle ScholarPubMed
57.Leclercq, R, Dutka-Malen, S, Brisson-Noel, A et al. , Transferable glycopeptide resistance in Enterococcus faecium: cloning and heterospecific expression of the van A gene. In: Abstracts of the 4th Europ Cong Clin Microbiol. Nice, 1989; 425.Google Scholar
58.Nicas, TI, Wy, CYE, Hobbs, JN, Preston, DA, Allen, NE.Characterization of vancomycin resistance in Enterococcus faecium and Enterococcus faecalis. Antimicrob Ag Chemother 1989; 33: 1121–4.CrossRefGoogle ScholarPubMed
59.Williamson, R, Al-Obeid, S, Shlaes, JH, Goldstein, FW, Shlaes, DM.Inducible resistance to vancomycin in Enterococcus faecium D366. J Infect Dis 1989; 159: 1095–1104.CrossRefGoogle ScholarPubMed
60.Courvalin, PM, Carlier, C, Collatz, E.Plasmid-mediated resistance to aminocyclitol antibiotics in group D streptococci. J Bacteriol 1980; 143: 541–51CrossRefGoogle ScholarPubMed
61.Eliopoulos, GM, Farber, BF, Murray, BE, Wennersten, CBG, Moellering, RC JrRihosomal resistance of clinical enterococci isolates to streptomycin. Antimicrob Ag Chemother 1984; 25: 398–9.CrossRefGoogle Scholar
62.Clewell, DB, Yagi, Y, Dunny, GM, Schultz, SK, Characterization of three plasmid deoxyribonucleic acid molecules in a strain of Streptococcus faecalis: identification of a plasmid determining erythromycin resistance. J Bacteriol 1974; 117: 283–9.CrossRefGoogle Scholar
63.Jacob, AE, Hobbs, SJ.Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var. zymogenes. J Bacteriol 1974; 117: 360–72.CrossRefGoogle ScholarPubMed
64.Le Bouguenec, C, Horodniceanu, T.Conjugative R plasmids in Streptococcus faecium (Group D). Antimicrob Ag Chemother 1982; 21: 698–705.CrossRefGoogle ScholarPubMed
65.Pepper, K, Le Bouguenec, C, de Cespedes, G, Horaud, T.Dispersal of a plasmid-borne chloramphenicol gene in streptococcal and enterococcal plasmids. Plasmid 1986; 16: 195–203.CrossRefGoogle ScholarPubMed
66.Stratton, CW, Liu, C, Ratner, HB, Weeks, LS.Bactericidal activity of deptomycin (LY146032) compared with those of ciprofloxacin, vancomycin and ampicillin against enterococci as determined by kill-kinetic studies. Antimicrob Ag Chemother 1987; 31: 1014–6.CrossRefGoogle ScholarPubMed
67.Liebowitz, LD, Saunders, J, Chalkley, LJ, Koornhof, HJ.In vitro selection of bacteria resistant to LY146032, a new cyclic lipopeptide. Antimicrob Ag Chemother 1988; 32: 24–6.CrossRefGoogle ScholarPubMed
68.Eliopoulos, GM, Willey, S, Reiszner, E, Spitzer, PG, Caputo, G, Moellering, RC JrIn vitro and in vivo activity of LY146032, a new cyclic lipopeptide antibiotic. Antimicrob Ag Chemother 1986; 30: 532–5.CrossRefGoogle ScholarPubMed
69.Miniter, PN, Patterson, TF, Johnson, MA, Andriole, AT.Activity of LY146032 in vitro and in experimental pyelonephritis. Antimicrob Ag Chemother 1987; 31: 1199–203.CrossRefGoogle Scholar
70.Sapico, FL, Ginunas, VJ, Canawati, HN, Montgomerie, JZ.LY146032. alone and in combination with gentamicin. for the treatment of enterococcal pyelonephritis in the rat model. Antimicrob Ag Chemother 1988; 32: 81–3.CrossRefGoogle ScholarPubMed
71.Barry, AL, Jones, RN.In vitro activities of temafloxacin, tosufloxacin (A-61827) and five other fluoroquinolone agents. J Antimicrob Chemother 1989; 23: 527–35.CrossRefGoogle ScholarPubMed
72.Moellering, RC JrWennersten, CBG, Weinberg, AN.Synergy of penicillin and gentamicin against enterococci. J Infect Dis 1971; 124 Suppl: 207–9.CrossRefGoogle ScholarPubMed
73.Grimm, H. Antibacterial activity of 18 antimicrobial agents and kill kinetics of ciprofloxacin plus ampicillin against gentamicin-resistant and high-level resistant enterococci. In 14th International Congress of Chemotherapy. Kyoto, Japan, 1985; Abs P. 37–80.Google Scholar
74.Iannini, PB, Ehret, J, Eickhoff, TC.Effects of ampicillin-amikacin and ampicillin-rifampicin on enterococci. Antimicrob Ag Chemother 1976; 9: 448–51.CrossRefGoogle ScholarPubMed
75.Watanakunakorn, C, Tisone, JC.Effects of a vancomycin-rifampicin combination on enterococci. Antimicrob Ag Chemother 1982; 22: 915–6.CrossRefGoogle Scholar
76.Gruneberg, RN, Emmerson, AM.Failure to prevent emergence of bacterial resistance by combination of two antimicrobials: fusidic acid and rifampicin. J Antimicrob Chemother 1980; 6: 562–4.CrossRefGoogle ScholarPubMed
77.Kerry, DW, Hamilton-Miller, JMT, Brumfitt, W.Trimethoprim and rifampicin: in vitro activities separately and in combination. J Antimicrob Chemother 1975; 1: 417–27.CrossRefGoogle ScholarPubMed
78.Smith, SM, Eng, RHK, Tecson-Tumang, F.Ciprofloxacin therapy for methicillin-resistant Staphylococcus aureus infections or colonizations. Antimicrob Ag Chemother 1989; 33: 181–4.CrossRefGoogle ScholarPubMed
79.Moellering, RC Jr, Korzeniowski, OM, Sande, MA, Wennersten, CB.Species-specific resistance to antimicrobial synergism in Streptococcus faecium and Streptococcus faecalis. J Infect Dis 1979; 140: 203–8.CrossRefGoogle ScholarPubMed
80.Report of a Working Party of the British Society for Antimicrobial Chemotherapy. The antibiotic prophylaxis of infective endocarditis. Lancet 1982; 2: 1323–6.Google Scholar
81.Coudron, PE, Mayhall, CG, Facklam, RR et al. , Streptococcus faecium outbreak in a neonatal intensive care unit. J Clin Microbiol 1984; 20: 1044–8.CrossRefGoogle Scholar
82.Lugenbuhl, LM, Rotbart, HA, Facklam, RR, Roe, MH, Elliot, JA.Neonatal enterococcal sepsis: case-control study and description of an outbreak. Pediatr Infect Dis J 1987; 6: 1022–6.CrossRefGoogle Scholar
83.Weems, JJ, Lowrence, JH, Baddour, LM, Simpson, WA.Molecular epidemiology of nosocomial. multiply aminoglycoside-resistant Eeterococcus faecalis. J Antimicrob chemother 1989; 24: 121–30.CrossRefGoogle ScholarPubMed
84.Tomich, PK, An, FY, Clewell, DB.Properties of erythromycin-inducible transposon Tn917 in Streptococcus faecalis. J Bacteriol 1980; 141; 1366–74.CrossRefGoogle ScholarPubMed
85.Franke, AE, Clewell, DB.Evidence for a chromosome-borne resistance transposon (Tn916) in Streptococcus faecalis that is capable of “conjugal” transfer in the absence of a conjugative plasmid. J Bacteriol 1981; 145: 494–502.CrossRefGoogle ScholarPubMed
86.Pepper, K, Horaud, T, Le Bouguenec, C, De Cespedes, G.Location of resistance markers in clinical isolates of Enterococcus faecalis with similar antibiotypes. Antimicrob Ag Chemother 1987; 31: 1394–1402.CrossRefGoogle ScholarPubMed
87.LeBlanc, DJ, Inamine, JM, Lee, LN.Broad geographical distribution of homologous erythromycin, kanamycin and streptomycin resistance determinants among group D streptococci of human and animal origin. Antimicrob Ag Chemother 1986; 29: 549–55.CrossRefGoogle Scholar