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A study of polio vaccination in infancy: excretion following challenge with live virus by children given killed or living poliovaccine

Published online by Cambridge University Press:  15 May 2009

J. L. Henry ,
E. S. Jaikaran ,
Joan R. Davies ,
A. J. H. Tomlinson ,
P. J. Mason ,
Joan M. Barnes  and
A. J. Beale
J. L. Henry
Affiliation:
London County Council
E. S. Jaikaran
Affiliation:
London County Council
Joan R. Davies
Affiliation:
Public Health Laboratory Service, County Hall, London, S.E. 1
A. J. H. Tomlinson
Affiliation:
Public Health Laboratory Service, County Hall, London, S.E. 1
P. J. Mason
Affiliation:
Glaxo Research Ltd, Sefion Park, Stoke Poges, Bucks.
Joan M. Barnes
Affiliation:
Glaxo Research Ltd, Sefion Park, Stoke Poges, Bucks.
A. J. Beale
Affiliation:
Glaxo Research Ltd, Sefion Park, Stoke Poges, Bucks.
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Quadruple vaccine containing 75 D antigen units of killed type 1 poliovirus was given to children at ages 2, 3 and 4 months followed by a booster dose at 15 months.

The serological response to the primary course was difficult to assess owing to maternal antibody. Antibody titres to the type 1 component after the booster dose were very satisfactory and about 10 times higher than those observed in a similar group of children given attenuated vaccine. Response to the poliovirus types 2 and 3 in the quadruple vaccine was less satisfactory.

Graded doses of attenuated poliovirus type 1 were fed to the children 2 months after the primary course and 1 month after the booster dose. Children who had received no poliovaccine and children immunized with attenuated vaccine were included for comparison.

Immunization with killed vaccine did not greatly affect the size of the minimal infecting dose of live virus but reduced both the duration of the subsequent infection and the titre of virus in the faeces.

The epidemiological significance of these findings is discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 64 , Issue 1 , March 1966 , pp. 105 - 120
Copyright
Copyright © Cambridge University Press 1966

References

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