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A study of infectious intestinal disease in England: risk factors associated with group A rotavirus in children

Published online by Cambridge University Press:  09 April 2001

D. SETHI ,
P. CUMBERLAND ,
M. J. HUDSON ,
L. C. RODRIGUES ,
J. G. WHEELER ,
J. A. ROBERTS ,
D. S. TOMPKINS ,
J. M. COWDEN  and
P. J. RODERICK
D. SETHI
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
P. CUMBERLAND
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
M. J. HUDSON
Affiliation:
Centre for Applied Microbiology and Research, Ponton Down, Salisbury, Wiltshire, UK
L. C. RODRIGUES
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
J. G. WHEELER
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
J. A. ROBERTS
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England
D. S. TOMPKINS
Affiliation:
Leeds Public Health Laboratory, York Road, Leeds, UK
J. M. COWDEN
Affiliation:
Scottish Centre for Infection and Environmental Health, Clifton Place, Glasgow, UK
P. J. RODERICK
Affiliation:
Southampton University, Southampton, UK
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Abstract

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Objective: To identify risk factors for infectious intestinal disease (IID) due to rotavirus group A in children aged under 16 years.

Methods: Case-control study of cases of IID with rotavirus infection presenting to general practitioners (GPs) or occurring in community cohorts, and matched controls.

Results: There were 139 matched pairs. In children under 16 years the following risk factors were significantly associated with rotavirus IID: living in rented council housing (adjusted OR=3·78, P=0·022), accommodation with more than five rooms (OR=0·72, P=0·002), contact with someone ill with IID (OR=3·45, P<0·001). Some foods were associated with decreased risk. In infants, bottle feeding with or without breast feeding was associated with increased risk (OR=9·06, P<0·05).

Conclusions: Contact with persons with IID, living in rented council housing and accommodation with fewer rooms, were significant risk factors for sporadic rotavirus IID in children whereas breast feeding is protective in infants.

Type
Research Article
Information
Epidemiology & Infection , Volume 126 , Issue 1 , February 2001 , pp. 63 - 70
Copyright
© 2001 Cambridge University Press