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Studies with inactivated equine influenza vaccine: 2. Protection against experimental infection with influenza virus A/equine/Newmarket/79 (H3N8)

Published online by Cambridge University Press:  15 May 2009

Jennifer Mumford ,
J. M. Wood ,
A. M. Scott ,
C. Folkers  and
G. C. Schild
Jennifer Mumford
Affiliation:
Equine Virology Unit, Animal Health Trust, Lanwades Park, Kennett, Newmarket, Suffolk, CB8 7DW
J. M. Wood
Affiliation:
Division of Viral Products, National Institute for Biological Standards and Control, Holly Hill, London NW3 6RB
A. M. Scott
Affiliation:
Equine Virology Unit, Animal Health Trust, Lanwades Park, Kennett, Newmarket, Suffolk, CB8 7DW
C. Folkers
Affiliation:
Animal Health Division, Duphar BV, C. J. van Houtenlaan 36, 1381 cp Weesp, Holland
G. C. Schild
Affiliation:
Division of Viral Products, National Institute for Biological Standards and Control, Holly Hill, London NW3 6RB
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Forty ponies immunized with inactivated virus vaccine containing A/equine/Miami/63 (H3N8) virus and six unvaccinated, seronegative ponies were experimentally challenged with a representative of recent equine H3N8 virus isolates, A/equine/Newmarket/79. All unvaccinated ponies became infected as judged by virus excretion, febrile responses and antibody responses, but only two of the vaccinated ponies were fully protected. Pre-challenge antibody levels to A/Newmarket/79 virus detected by single radial haemolysis (SRH) correlated well with the degree of clinical protection but the levels required for complete protection (SRH zones > 65 mm2) were high. The importance of these results in relation to conventional vaccination procedures against equine influenza is discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 90 , Issue 3 , June 1983 , pp. 385 - 396
Copyright
Copyright © Cambridge University Press 1983

References

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